Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway

Metabolism ◽  
2018 ◽  
Vol 79 ◽  
pp. 10-23 ◽  
Author(s):  
Jingren Xu ◽  
Canjun Zhu ◽  
Mengyuan Zhang ◽  
Qingchun Tong ◽  
Xiaojuan Wan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Resistance ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Inflammatory Pathway ◽  
Growth Hormone Resistance

Barth syndrome with severe dilated cardiomyopathy and growth hormone resistance: a case report

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Joel A. Vanderniet ◽  
Paul Z. Benitez-Aguirre ◽  
Carolyn R. Broderick ◽  
Richard I. Kelley ◽  
Shanti Balasubramaniam
Keyword(s):  
Growth Hormone ◽  
Dilated Cardiomyopathy ◽  
Corn Starch ◽  
Primary Hypothyroidism ◽  
Barth Syndrome ◽  
Height Velocity ◽  
Growth Delay ◽  
Hormone Resistance ◽  
Feeding Difficulties ◽  
Growth Hormone Resistance

Abstract Objectives To describe the metabolic and endocrine features of a patient with Barth syndrome who showed evidence of growth hormone resistance. Case presentation A male proband deteriorated rapidly with lactic acidosis after a circumcision at age three weeks and was found to have severe dilated cardiomyopathy. A cardiomyopathy gene panel led to the diagnosis of TAZ-deficiency Barth syndrome. He subsequently experienced hypotonia and gross motor delay, feeding difficulties for the first four years, constitutional growth delay and one episode of ketotic hypoglycaemia. Cardiomyopathy resolved on oral anti-failure therapy by age three years. He had a hormonal pattern of growth hormone resistance, and growth hormone treatment was considered, however height velocity improved spontaneously after age 3½ years. He also had biochemical primary hypothyroidism. Conclusions With careful metabolic management with l-arginine supplementation, overnight corn starch, and a prescribed exercise program, our patient’s strength, endurance, level of physical activity and body composition improved significantly by age six years.

scholarly journals Growth hormone resistance in severe heart failure resolves after cardiac transplantation

2009 ◽  
Vol 11 (5) ◽  
pp. 525-528 ◽  
Author(s):  
Lars H. Lund ◽  
Pamela Freda ◽  
Jill J. Williams ◽  
John J. LaManca ◽  
Thierry H. LeJemtel ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Hormone ◽  
Cardiac Transplantation ◽  
Severe Heart Failure ◽  
Hormone Resistance ◽  
Growth Hormone Resistance

scholarly journals Effects of uremia and inflammation on growth hormone resistance in patients with chronic kidney diseases

2008 ◽  
Vol 74 (7) ◽  
pp. 937-945 ◽  
Author(s):  
Giacomo Garibotto ◽  
Rodolfo Russo ◽  
Antonella Sofia ◽  
Diego Ferone ◽  
Fulvio Fiorini ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Kidney Diseases ◽  
Hormone Resistance ◽  
Chronic Kidney Diseases ◽  
Growth Hormone Resistance

scholarly journals GROWTH HORMONE DEFICIENCY (GHD) AND GROWTH HORMONE RESISTANCE (GHR) IN INDIAN CHILDREN

1993 ◽  
Vol 33 ◽  
pp. S33-S33
Author(s):  
M P Desai ◽  
P Colaco ◽  
C Choksi ◽  
M Ambadkar ◽  
F E Vaz ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Hormone Deficiency ◽  
Hormone Deficiency ◽  
Hormone Resistance ◽  
Indian Children ◽  
Growth Hormone Resistance

TNF-α and Growth Hormone Resistance in Patients with Chronic Liver Disease

2003 ◽  
Vol 23 (5) ◽  
pp. 229-235 ◽  
Author(s):  
Antonio Picardi ◽  
Umberto Vespasiani Gentilucci ◽  
Enrico Maria Zardi ◽  
Domenico Caccavo ◽  
Tommasangelo Petitti ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Chronic Liver ◽  
Hormone Resistance ◽  
Growth Hormone Resistance ◽  
Tnf Α

scholarly journals Is Growth Hormone Resistance/IGF-1 Reduction Good for You?

2011 ◽  
Vol 13 (4) ◽  
pp. 355-356 ◽  
Author(s):  
Emily Jane Gallagher ◽  
Derek LeRoith
Keyword(s):  
Growth Hormone ◽  
Hormone Resistance ◽  
Growth Hormone Resistance ◽  
Good For

scholarly journals Acquired growth hormone resistance in patients with chronic heart failure: implications for therapy with growth hormone

2001 ◽  
Vol 38 (2) ◽  
pp. 443-452 ◽  
Author(s):  
Stefan D Anker ◽  
Maurizio Volterrani ◽  
Claus-Dieter Pflaum ◽  
Christian J Strasburger ◽  
Karl Josef Osterziel ◽  
...  
Keyword(s):  
Heart Failure ◽  
Growth Hormone ◽  
Chronic Heart Failure ◽  
Hormone Resistance ◽  
Growth Hormone Resistance
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