Neutrophil cell signaling in infection: role of phosphatidylinositide 3-kinase

2003 ◽  
Vol 5 (14) ◽  
pp. 1293-1298 ◽  
Author(s):  
Theo J. Moraes ◽  
Gregory P. Downey
Keyword(s):  
Cell Signaling ◽  
Neutrophil Cell

scholarly journals Epigenetic regulation by the menin pathway

2017 ◽  
Vol 24 (10) ◽  
pp. T147-T159 ◽  
Author(s):  
Zijie Feng ◽  
Jian Ma ◽  
Xianxin Hua
Keyword(s):  
Transcription Factors ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Gene Transcription ◽  
Epigenetic Regulation ◽  
Posttranslational Modifications ◽  
Genetic Model ◽  
Mirna Biogenesis ◽  
Endocrine Organs

There is a trend of increasing prevalence of neuroendocrine tumors (NETs), and the inherited multiple endocrine neoplasia type 1 (MEN1) syndrome serves as a genetic model to investigate how NETs develop and the underlying mechanisms. Menin, encoded by the MEN1 gene, at least partly acts as a scaffold protein by interacting with multiple partners to regulate cellular homeostasis of various endocrine organs. Menin has multiple functions including regulation of several important signaling pathways by controlling gene transcription. Here, we focus on reviewing the recent progress in elucidating the key biochemical role of menin in epigenetic regulation of gene transcription and cell signaling, as well as posttranslational regulation of menin itself. In particular, we will review the progress in studying structural and functional interactions of menin with various histone modifiers and transcription factors such as MLL, PRMT5, SUV39H1 and other transcription factors including c-Myb and JunD. Moreover, the role of menin in regulating cell signaling pathways such as TGF-beta, Wnt and Hedgehog, as well as miRNA biogenesis and processing will be described. Further, the regulation of the MEN1 gene transcription, posttranslational modifications and stability of menin protein will be reviewed. These various modes of regulation by menin as well as regulation of menin by various biological factors broaden the view regarding how menin controls various biological processes in neuroendocrine organ homeostasis.

Role of acylCoA binding protein in acylCoA transport, metabolism and cell signaling

1999 ◽  
pp. 95-103
Author(s):  
Jens Knudsen ◽  
Mette Valentin Jensen ◽  
Jan Krogh Hansen ◽  
Nils J. Færgeman ◽  
Thomas B. F. Neergaard ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Binding Protein

The Tissue Factor Pathway and Wound Healing

2017 ◽  
Vol 44 (02) ◽  
pp. 142-150 ◽  
Author(s):  
Maureane Hoffman
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Cell Signaling ◽  
Tissue Factor ◽  
Blood Coagulation ◽  
Host Response ◽  
Cellular Processes ◽  
Injured Tissue ◽  
Tissue Factor Pathway

AbstractThe role of tissue factor (TF) as the major initiator of hemostatic blood coagulation is well recognized. The ability to form an adequate hemostatic clot is essential to the normal healing of an injury by staunching bleeding, stabilizing the injured tissue, and serving as a scaffold for repair processes. Also, some molecules produced during hemostasis, particularly thrombin, have cytokine and growth factor-like activities that contribute to inflammation and repair. However, TF itself has activities as a regulator of cellular processes via direct signaling, as well as by facilitating activation of proteolytically activated receptors by activated factors VII and X. The importance of hemostasis in the host response to injury makes it very difficult to separate the hemostatic from nonhemostatic effects of TF on wound healing. The literature in this area remains sparse but suggests that TF influences the course and tempo of healing by cell signaling events that impact inflammation, epithelialization, and angiogenesis.

scholarly journals Dual role of endothelial cell signaling in cancer progression

2015 ◽  
Vol 26 ◽  
pp. iii29
Author(s):  
D.A. Ferraro ◽  
R. Goosen ◽  
F. Patella ◽  
S. Zanivan ◽  
M. Buess ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Signaling ◽  
Cancer Progression ◽  
Dual Role

The role of ceramide in cell signaling

1998 ◽  
Vol 1436 (1-2) ◽  
pp. 233-243 ◽  
Author(s):  
David K Perry ◽  
Yusuf A Hannun
Keyword(s):  
Cell Signaling

scholarly journals Role of Disorder in T-Cell Signaling

2012 ◽  
Vol 102 (3) ◽  
pp. 2a
Author(s):  
Kai Wucherpfennig
Keyword(s):  
T Cell ◽  
Cell Signaling ◽  
T Cell Signaling
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