Immunization with proline rich region of pneumococcal surface protein A has no role in protection against Streptococcus pneumoniae serotype 19F

2020 ◽  
Vol 138 ◽  
pp. 103761 ◽  
Author(s):  
Michael M. Girgis ◽  
Abeer M. Abd El-Aziz ◽  
Ramadan Hassan ◽  
Youssif M. Ali
Keyword(s):  
Streptococcus Pneumoniae ◽  
Protein A ◽  
Surface Protein ◽  
Rich Region ◽  
Pneumococcal Surface Protein A ◽  
Proline Rich Region

scholarly journals A Synthetic Virus-Like Particle Streptococcal Vaccine Candidate Using B-Cell Epitopes from the Proline-Rich Region of Pneumococcal Surface Protein A

Vaccines ◽  
2015 ◽  
Vol 3 (4) ◽  
pp. 850-874 ◽  
Author(s):  
Marco Tamborrini ◽  
Nina Geib ◽  
Aniebrys Marrero-Nodarse ◽  
Maja Jud ◽  
Julia Hauser ◽  
...  
Keyword(s):  
B Cell ◽  
Vaccine Candidate ◽  
Protein A ◽  
Surface Protein ◽  
Rich Region ◽  
B Cell Epitopes ◽  
Pneumococcal Surface Protein A ◽  
Virus Like Particle ◽  
Proline Rich Region

scholarly journals DNA vaccines expressing pneumococcal surface protein A (PspA) elicit protection levels comparable to recombinant protein

2006 ◽  
Vol 55 (4) ◽  
pp. 375-378 ◽  
Author(s):  
Daniela M. Ferreira ◽  
Eliane N. Miyaji ◽  
Maria Leonor S. Oliveira ◽  
Michelle Darrieux ◽  
Ana Paula M. Arêas ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Recombinant Protein ◽  
Dna Vaccines ◽  
Protein A ◽  
Surface Protein ◽  
Humoral Response ◽  
Cost Effective ◽  
Promising Candidate ◽  
Pneumococcal Surface Protein A ◽  
Antibody Levels

Pneumococcal surface protein A (PspA) is a promising candidate for the development of cost-effective vaccines against Streptococcus pneumoniae. In the present study, BALB/c mice were immunized with DNA vaccine vectors expressing the N-terminal region of PspA. Animals immunized with a vector expressing secreted PspA developed higher levels of antibody than mice immunized with the vector expressing the antigen in the cytosol. However, both immunogens elicited similar levels of protection against intraperitoneal challenge. Furthermore, immunization with exactly the same fragment in the form of a recombinant protein, with aluminium hydroxide as an adjuvant, elicited even higher antibody levels, but this increased humoral response did not correlate with enhanced protection. These results show that DNA vaccines expressing PspA are able to elicit protection levels comparable to recombinant protein, even though total anti-PspA IgG response is considerably lower.

scholarly journals Determination of phenotypes and pneumococcal surface protein A family types of Streptococcus pneumoniae from Malaysian healthy children

2013 ◽  
Vol 46 (3) ◽  
pp. 180-186 ◽  
Author(s):  
Masura Mohd Yatim ◽  
Siti Norbaya Masri ◽  
Mohd Nasir Mohd Desa ◽  
Niazlin Mohd Taib ◽  
Syafinaz Amin Nordin ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Protein A ◽  
Surface Protein ◽  
Healthy Children ◽  
Pneumococcal Surface Protein A ◽  
Family Types

Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children

Vaccine ◽  
2007 ◽  
Vol 25 (6) ◽  
pp. 1030-1035 ◽  
Author(s):  
Christiane Heeg ◽  
Carmen Franken ◽  
Mark van der Linden ◽  
Adnan Al-Lahham ◽  
Ralf René Reinert
Keyword(s):  
Genetic Diversity ◽  
Streptococcus Pneumoniae ◽  
Protein A ◽  
Surface Protein ◽  
Pneumococcal Surface Protein A ◽  
German Children
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