A comprehensive screening of the whole proteome of hantavirus and designing a multi-epitope subunit vaccine for cross-protection against hantavirus: Structural vaccinology and immunoinformatics study

2021 ◽  
Vol 150 ◽  
pp. 104705
Author(s):  
Faruq Abdulla ◽  
Zulkar Nain ◽  
Md. Moyazzem Hossain ◽  
Shifath Bin Syed ◽  
Md Shakil Ahmed Khan ◽  
...  
Keyword(s):  
Subunit Vaccine ◽  
Cross Protection ◽  
Structural Vaccinology

Evaluation of the immunoprotective effects of IF-2 GTPase and SSU05-1022 as Streptococcus suis candidate subunit vaccine

2021 ◽  
Author(s):  
Tumei Chen ◽  
Chenchen Wang ◽  
Linlin Hu ◽  
Hao Lu ◽  
Fangyu Song ◽  
...  
Keyword(s):  
Recombinant Proteins ◽  
Subunit Vaccine ◽  
Streptococcus Suis ◽  
Cross Protection ◽  
Cytokine Levels ◽  
Antibody Titers ◽  
A Subunit ◽  
Suis Serotype ◽  
Lethal Doses ◽  
Mixed Protein

Aim: This study aims to develop a subunit vaccine with high cross-protection for Streptococcus suis. Materials & methods: Four-week-old female BALB/c mice were first immunized with a single and mixed protein. Various indicators, such as antibody titers and various cytokine levels, were further analyzed. Results: The results showed that purified recombinant proteins IF-2 and 1022 had a good protective effect against lethal doses of S. suis serotype 2 and S. suis serotype 9. This study showed immunization with recombinant proteins. Conclusion: IF-2 and 1022 can enhance cross-protection against S. suis serotypes 2 and 9.

Reverse and structural vaccinology approach to design a highly immunogenic multi-epitope subunit vaccine against Streptococcus pneumoniae infection

2020 ◽  
Vol 85 ◽  
pp. 104473
Author(s):  
Lohany Dias Mamede ◽  
Keila Gonçalves de Paula ◽  
Bianca de Oliveira ◽  
Janete Soares Coelho dos Santos ◽  
Lucas Maciel Cunha ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Subunit Vaccine ◽  
Structural Vaccinology

Designing a multi-epitope vaccine for cross-protection against Shigella spp: An immunoinformatics and structural vaccinology study

2019 ◽  
Vol 116 ◽  
pp. 106-116 ◽  
Author(s):  
Mokhtar Nosrati ◽  
Abbas Hajizade ◽  
Shahram Nazarian ◽  
Jafar Amani ◽  
Amir Namvar Vansofla ◽  
...  
Keyword(s):  
Cross Protection ◽  
Epitope Vaccine ◽  
Shigella Spp ◽  
Structural Vaccinology

Effect of transfer factor on immune efficacy of PCV2 subunit vaccine

2014 ◽  
Vol 39 (4) ◽  
pp. 409-412
Author(s):  
Tai-long QU ◽  
Run-cheng LI ◽  
Xing QIAN ◽  
Yu YANG ◽  
Xing-long YU
Keyword(s):  
Transfer Factor ◽  
Subunit Vaccine ◽  
Immune Efficacy

Development and efficacy of a grass carp reovirus (GCRV) outer capsid protein VP7 subunit vaccine

2012 ◽  
Vol 37 (6) ◽  
pp. 659-664 ◽  
Author(s):  
Shi-ying XU ◽  
Jing-hui LI ◽  
Yong ZOU ◽  
Lin LIU ◽  
Cheng-liang GONG ◽  
...  
Keyword(s):  
Capsid Protein ◽  
Grass Carp ◽  
Subunit Vaccine ◽  
Outer Capsid Protein ◽  
Grass Carp Reovirus ◽  
Outer Capsid
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