scholarly journals Role of single photon emission computerised tomography in evaluating osseointegration of indigenous DRDO implants: An in vivo study

2016 ◽  
Vol 72 (1) ◽  
pp. 48-53
Author(s):  
S.K. Bhandari ◽  
Anupam Mondal
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
In Vivo Study ◽  
Single Photon Emission ◽  
Computerised Tomography

In vivo stability of protein coatings on poly lactic co glycolic nanoparticles

MRS Advances ◽  
2016 ◽  
Vol 1 (56) ◽  
pp. 3767-3773 ◽  
Author(s):  
Jordi Llop ◽  
Marco Marradi ◽  
Pengfei Jiang ◽  
Vanessa Gómez-Vallejo ◽  
Zuriñe Baz ◽  
...  
Keyword(s):  
Electrophilic Substitution ◽  
Single Photon ◽  
Photon Emission ◽  
Degradation Process ◽  
Energy Spectra ◽  
Single Photon Emission ◽  
Computerised Tomography ◽  
The Core ◽  
Wide Range

ABSTRACTSubmicron-sized poly(lactide-co-glycolide) nanoparticles (PLGA-NPs) stabilised with bovine serum albumin (BSA) are dual radiolabelled using gamma emitters with different energy spectra incorporated into the core and coating. PLGA core is labelled by encapsulation of 111In-doped iron oxide NPs inside PLGA-NPs during NP preparation, while the BSA coating is labelled by electrophilic substitution using 125I. After intravenous administration into rats, energy-discriminant single-photon emission computerised tomography (SPECT) resolved each radioisotope independently. Imaging revealed different fates for the core and coating, with a fraction of the two radionuclides co-localising in the liver and lungs for long periods of time after administration, suggesting that NPs are stable in these organs. The general methodology reported here represents an excellent alternative for visualising the degradation process of multi-labelled NPs in vivo and can be extended to a wide range of engineered NPs.

Imaging drug action in schizophrenia: research update

2003 ◽  
Vol 18 (S2) ◽  
pp. 32s-37s ◽  
Author(s):  
Marc Laruelle ◽  
Anissa Abi-Dargham
Keyword(s):  
Functional Neuroimaging ◽  
Single Photon ◽  
Photon Emission ◽  
Drug Action ◽  
Emission Tomography ◽  
Single Photon Emission ◽  
Computerised Tomography ◽  
Positron Emission ◽  
And Function

Functional neuroimaging using techniques such as positron emission tomography (PET) and single photon emission computerised tomography (SPECT) provide a direct in vivo assessment of the expression and function of neuroreceptors, transporters and enzymes. This article examines the technical aspects of molecular imaging and the application of those techniques in drug development.

A Pilot Study of Schizophrenia-Like Psychosis in Epilepsy Using Single-Photon Emission Computerised Tomography

1993 ◽  
Vol 163 (1) ◽  
pp. 32-36 ◽  
Author(s):  
E. Jane Marshall ◽  
G. M. S. Syed ◽  
P. B. C. Fenwick ◽  
W. A. Lishman
Keyword(s):  
Pilot Study ◽  
Single Photon ◽  
Photon Emission ◽  
Temporal Region ◽  
Single Photon Emission ◽  
Computerised Tomography ◽  
Matched Group

In a pilot study, SPECT was used to explore differences in rCBF between a group of patients with schizophrenia-like psychoses of epilepsy (SLPE) and a matched group of epileptic controls. Five patients in each group were investigated and those with SLPE showed significant reductions in the index of rCBF in the left medial temporal region. These differences are being investigated further.

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