Regulating distal tip cell migration in space and time

Many neurons resemble other cells in developing embryos in migrating long distances before they differentiate. However, despite shared basic machinery, neurons differ from other migrating cells. Most dramatically, migrating neurons have a long and dynamic leading process, and may extend an axon from the rear while they migrate. Neurons must coordinate the extension and branching of their leading processes, cell movement with axon specification and extension, switching between actin and microtubule motors, and attachment and recycling of diverse adhesion proteins. New research is needed to fully understand how migration of such morphologically complicated cells is coordinated over space and time.

Download Full-text

Faculty Opinions recommendation of YAP/TAZ-CDC42 signaling regulates vascular tip cell migration.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.731737114.793537584 ◽

2017 ◽

Author(s):

Jonathan Chernoff

Keyword(s):

Cell Migration ◽

Tip Cell

Download Full-text

Tip-Cell Migration Controls Stalk-Cell Intercalation during Drosophila Tracheal Tube Elongation

Current Biology ◽

10.1016/j.cub.2008.10.062 ◽

2008 ◽

Vol 18 (22) ◽

pp. 1727-1734 ◽

Cited By ~ 92

Author(s):

Emmanuel Caussinus ◽

Julien Colombelli ◽

Markus Affolter

Keyword(s):

Cell Migration ◽

Tracheal Tube ◽

Stalk Cell ◽

Tip Cell ◽

Cell Intercalation

Download Full-text

The dosage-dependent effect exerted by the NM23-H1/H2 homolog NDK-1 on distal tip cell migration in C. elegans

Laboratory Investigation ◽

10.1038/labinvest.2017.99 ◽

2017 ◽

Vol 98 (2) ◽

pp. 182-189 ◽

Cited By ~ 4

Author(s):

Zsolt Farkas ◽

Luca Fancsalszky ◽

Éva Saskői ◽

Alexandra Gráf ◽

Krisztián Tárnok ◽

...

Keyword(s):

Cell Migration ◽

Dependent Effect ◽

Tip Cell ◽

C Elegans

Download Full-text

New insights in chemokine signaling

F1000Research ◽

10.12688/f1000research.13130.1 ◽

2018 ◽

Vol 7 ◽

pp. 95 ◽

Cited By ~ 27

Author(s):

Daniel F. Legler ◽

Marcus Thelen

Keyword(s):

Cell Migration ◽

Chemokine Receptors ◽

Local Environment ◽

Receptor Activation ◽

Space And Time ◽

Chemokine Signaling ◽

Discrete Contact ◽

Biased Signaling ◽

Chemokine Gradient ◽

Dynamic Structures

Chemokine signaling is essential for coordinated cell migration in health and disease to specifically govern cell positioning in space and time. Typically, chemokines signal through heptahelical, G protein-coupled receptors to orchestrate cell migration. Notably, chemokine receptors are highly dynamic structures and signaling efficiency largely depends on the discrete contact with the ligand. Promiscuity of both chemokines and chemokine receptors, combined with biased signaling and allosteric modulation of receptor activation, guarantees a tightly controlled recruitment and positioning of individual cells within the local environment at a given time. Here, we discuss recent insights in understanding chemokine gradient formation by atypical chemokine receptors and how typical chemokine receptors can transmit distinct signals to translate guidance cues into coordinated cell locomotion in space and time.

Download Full-text