scholarly journals RNA Homeostasis Governed by Cell Type-Specific and Branched Feedback Loops Acting on NMD

2011 ◽  
Vol 43 (6) ◽  
pp. 950-961 ◽  
Author(s):  
Lulu Huang ◽  
Chih-Hong Lou ◽  
Waikin Chan ◽  
Eleen Y. Shum ◽  
Ada Shao ◽  
...  
Keyword(s):  
Feedback Loops ◽  
Cell Type ◽  
Cell Type Specific

Cell-type specific utilization of multiple negative feedback loops generates developmental constancy

2005 ◽  
Vol 10 (7) ◽  
pp. 743-752 ◽  
Author(s):  
Masaki Iwanami ◽  
Yasushi Hiromi ◽  
Masataka Okabe
Keyword(s):  
Negative Feedback ◽  
Feedback Loops ◽  
Cell Type ◽  
Negative Feedback Loops ◽  
Cell Type Specific

scholarly journals Cell-autonomous clock of astrocytes drives circadian behavior in mammals

Science ◽  
2019 ◽  
Vol 363 (6423) ◽  
pp. 187-192 ◽  
Author(s):  
Marco Brancaccio ◽  
Mathew D. Edwards ◽  
Andrew P. Patton ◽  
Nicola J. Smyllie ◽  
Johanna E. Chesham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Suprachiasmatic Nucleus ◽  
Clock Gene ◽  
Feedback Loops ◽  
Cell Type ◽  
Daily Rhythms ◽  
Clock Gene Expression ◽  
Negative Feedback Loops ◽  
Cell Type Specific ◽  
Circadian Behavior

Circadian (~24-hour) rhythms depend on intracellular transcription-translation negative feedback loops (TTFLs). How these self-sustained cellular clocks achieve multicellular integration and thereby direct daily rhythms of behavior in animals is largely obscure. The suprachiasmatic nucleus (SCN) is the fulcrum of this pathway from gene to cell to circuit to behavior in mammals. We describe cell type–specific, functionally distinct TTFLs in neurons and astrocytes of the SCN and show that, in the absence of other cellular clocks, the cell-autonomous astrocytic TTFL alone can drive molecular oscillations in the SCN and circadian behavior in mice. Astrocytic clocks achieve this by reinstating clock gene expression and circadian function of SCN neurons via glutamatergic signals. Our results demonstrate that astrocytes can autonomously initiate and sustain complex mammalian behavior.

IFIH1-deficiency results in a cell-type specific alteration of autophagic activity in response to S. typhimurium

2017 ◽  
Vol 55 (05) ◽  
pp. e28-e56
Author(s):  
S Macheiner ◽  
R Gerner ◽  
A Pfister ◽  
A Moschen ◽  
H Tilg
Keyword(s):  
Cell Type ◽  
A Cell ◽  
Cell Type Specific ◽  
Autophagic Activity ◽  
Specific Alteration

Cell Type–Specific Transcriptional and Epigenetic Profiles from a Rare Neuronal Population within the Arcuate Nucleus

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2430-PUB
Author(s):  
FRANKIE D. HEYWARD ◽  
EVAN ROSEN
Keyword(s):  
Arcuate Nucleus ◽  
Neuronal Population ◽  
Cell Type ◽  
Cell Type Specific
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