Double role of mannose-binding lectin in relation to carotid intima–media thickness in patients with rheumatoid arthritis

2010 ◽  
Vol 47 (4) ◽  
pp. 713-718 ◽  
Author(s):  
Lone N. Troelsen ◽  
Peter Garred ◽  
Buris Christiansen ◽  
Christian Torp-Pedersen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin

Serum levels of mannose binding lectin are associated with carotid intima-media thickness in patients with rheumatoid arthritis

2009 ◽  
Vol 46 (14) ◽  
pp. 2870
Author(s):  
Lone N. Troelsen ◽  
Peter Garred ◽  
Buris Christiansen ◽  
Christian Torp-Pedersen ◽  
Ib J. Christensen ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Serum Levels ◽  
Mannose Binding Lectin ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Levels and Carotid Intima-Media Thickness in Type 2 Diabetic Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Miklós Káplár ◽  
Shah Sweni ◽  
Julianna Kulcsár ◽  
Barbara Cogoi ◽  
Regina Esze ◽  
...  
Keyword(s):  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Diabetic Patients ◽  
Media Thickness ◽  
Significant Difference ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Type 2 Diabetic

Introduction. Mannose-binding lectin (MBL) activates complement system and has been suggested to play a role in vascular complications in diabetics. Carotid intima-media thickness (cIMT) detects subclinical atherosclerosis. We evaluated the association of MBL and IMT in type 2 diabetic (T2DM) patients.Methods. Serum MBL levels and cIMT were measured in a total of 103 diabetics and in 98 age-matched healthy controls.Results. There was no significant difference in MBL level in T2DM versus controls. As expected, IMT was significantly higher in T2DM patients than in controls (P=0.001). In T2DM, the lowest cIMT was seen in patients with normal MBL level (500–1000) while cIMT continuously increased with both high MBL and absolute MBL deficiency states. This was especially significant in high MBL versus normal MBL T2DM patients (P=0.002). According to multiple regression analysis the main predictors of IMT in T2DM are age (P<0.003), ApoA level (P=0.023), and the MBL (P=0.036).Conclusions. Our results suggest a dual role of MBL as a risk factor for cIMT in T2DM. MBL may also be used as a marker of macrovascular disease, as both low and high levels indicate the susceptibility for atherosclerosis in T2DM.

Common Carotid Intima-media Thickness in Patients with Late Rheumatoid Arthritis; What Is the Role of Gender?

2011 ◽  
Vol 14 (16) ◽  
pp. 812-816 ◽  
Author(s):  
Abolhassan Shakeri ◽  
Mohammad Babaei Bazzaz ◽  
Alireza Khabbazi ◽  
Rohollah Fadaei Fouladi
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

SAT0213 Association of mannose-binding lectin gene polymorphisms with intima-media thickness (IMT) in primary antiphospholipid syndrome

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 544.1-544
Author(s):  
A. Barrera-Cruz ◽  
A.M. Carmona-Becerril ◽  
Y.-M. Anguiano-Hernandez ◽  
C. Hernandez-Gonzalez ◽  
G. Medina-García ◽  
...  
Keyword(s):  
Antiphospholipid Syndrome ◽  
Gene Polymorphisms ◽  
Intima Media Thickness ◽  
Mannose Binding Lectin ◽  
Primary Antiphospholipid Syndrome ◽  
Lectin Gene ◽  
Media Thickness ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding Lectin Gene Polymorphisms in Brazilian Patients with Rheumatoid Arthritis

2011 ◽  
Vol 39 (1) ◽  
pp. 6-9 ◽  
Author(s):  
FERNANDA LETICIA MARTINY ◽  
TIAGO DEGANI VEIT ◽  
CLAITON VIEGAS BRENOL ◽  
JOÃO CARLOS TAVARES BRENOL ◽  
RICARDO MACHADO XAVIER ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphisms ◽  
Clinical Manifestations ◽  
Mannose Binding Lectin ◽  
Unknown Etiology ◽  
Significant Difference ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Reaction Sequencing

Objective.Rheumatoid arthritis (RA) is a disease with unknown etiology but it is probably multifactorial. RA susceptibility is related to genetic, hormonal, immunologic, and environmental factors. Mannose-binding lectin (MBL) is an important protein of the human innate immune system, encoded by the MBL2 gene. Polymorphisms in MBL2 were associated with several diseases, and may be an important factor in RA susceptibility. We analyzed 3 MBL2 gene polymorphisms in 322 Brazilian patients with RA and 345 ethnically matched healthy controls.Methods.MBL2 gene variants were analyzed through polymerase chain reaction sequencing.Results.Considering MBL2 B, C, and D alleles separately, a significant difference in both genotypic and allelic frequencies, particularly concerning frequency of the C allele, was observed comparing European-derived and African-derived individuals (European-derived patients 0.022 vs African-derived patients 0.205; European-derived controls 0.029 vs African-derived controls 0.144; both p < 0.001). We also analyzed MBL2 genotype in relation to extraarticular manifestations. Considering MBL2 variants together, we found an increased frequency of the OO genotype among patients with rheumatoid nodules (p = 0.031), although this association lost significance after Bonferroni correction.Conclusion.Our findings suggest an association of MBL2 genotypes with some clinical manifestations of RA, but more studies are needed to clarify the actual role of MBL in RA.

scholarly journals Plasma expression of microRNA-425-5p and microRNA-451a as biomarkers of cardiovascular disease in rheumatoid arthritis patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Delia Taverner ◽  
Dídac Llop ◽  
Roser Rosales ◽  
Raimon Ferré ◽  
Luis Masana ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Cardiovascular Disease ◽  
Pulse Wave Velocity ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Disease Risk ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Epigenetic Biomarkers

AbstractTo validate in a cohort of 214 rheumatoid arthritis patients a panel of 10 plasmatic microRNAs, which we previously identified and that can facilitate earlier diagnosis of cardiovascular disease in rheumatoid arthritis patients. We identified 10 plasma miRs that were downregulated in male rheumatoid arthritis patients and in patients with acute myocardial infarction compared to controls suggesting that these microRNAs could be epigenetic biomarkers for cardiovascular disease in rheumatoid arthritis patients. Six of those microRNAs were validated in independent plasma samples from 214 rheumatoid arthritis patients and levels of expression were associated with surrogate markers of cardiovascular disease (carotid intima-media thickness, plaque formation, pulse wave velocity and distensibility) and with prior cardiovascular disease. Multivariate analyses adjusted for traditional confounders and treatments showed that decreased expression of microRNA-425-5p in men and decreased expression of microRNA-451 in women were significantly associated with increased (β = 0.072; p = 0.017) and decreased carotid intima-media thickness (β = −0.05; p = 0.013), respectively. MicroRNA-425-5p and microRNA-451 also increased the accuracy to discriminate patients with pathological carotid intima-media thickness by 1.8% (p = 0.036) in men and 3.5% (p = 0.027) in women, respectively. In addition, microRNA-425-5p increased the accuracy to discriminate male patients with prior cardiovascular disease by 3% (p = 0.008). Additionally, decreased expression of microRNA-451 was significantly associated with decreased pulse wave velocity (β = −0.72; p = 0.035) in overall rheumatoid arthritis population. Distensibility showed no significant association with expression levels of the microRNAs studied. We provide evidence of a possible role of microRNA-425-5p and microRNA-451 as useful epigenetic biomarkers to assess cardiovascular disease risk in patients with rheumatoid arthritis.

scholarly journals AB0234 ASSOCIATION OF HOMOCYSTEINE LEVEL AND CAROTID INTIMA-MEDIA THICKNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1417.3-1417
Author(s):  
D. Anghel ◽  
L. Otlocan ◽  
R. Bursuc ◽  
E. Busuioc ◽  
A. Manolache ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Homocysteine Level ◽  
Intima Media Thickness ◽  
Antiplatelet Agents ◽  
Carotid Intima Media Thickness ◽  
Tnf Alpha ◽  
Das28 Score ◽  
Media Thickness ◽  
Alpha Therapy

Background:Homocysteine (Hcy) has been implicated in atherogenesis. High homocysteine level can predict cardiovascular events, including death. Atherosclerosis has a high incidence in patients with Rheumatoid Arthritis (RA).Objectives:The aim of this study is to evaluate the relationship between serum homocysteine levels and carotid atherosclerosis in patients with RA and anti-TNF therapy.Methods:Our study included 80 RA patients divided into two groups: 45 patients were with anti-TNF-alpha therapy (Adalimumab, Infliximab, Etanercept) and 35 RA patients with disease-modifying antirheumatic drugs (DMARDs). The patients were diagnosed with RA used ACR/EULAR 2010 Classification Criteria. We measured carotid intima-media thickness (CIMT) using high-resolution Doppler ultrasonography at baseline and then at 12 months. CIMT above 0.9 mm is an atherosclerosis marker. We considered high levels of homocysteine in the serum above 15 µmol/L. All patients had treatment with hypolipemiant drugs and antiplatelet agents during the 12 months. Other parameters were analyzed at baseline and after 12 months: age, lipid profile (HDL, LDL, and cholesterol), ESR and disease activity score (DAS28<2.6 means remission; DAS28=2.6-3.2 means low disease activity, DAS28=3.2-5.1 means moderate disease activity; DAS28>5.1 high disease activity).Results:45 patients received anti-TNF-alpha therapy (mean age 45.50±9.69 years) and 35 RA patients had treatment with DMARDs (mean age 48.3±8.9 years). High Hcy levels were found on 34% patients in DMARDs group and 21% patients in anti-TNF group. After 12 months of treatment, patients with high levels of Hcy and anti-TNF therapy had a significant decrease in CIMT. In patients with low Hcy level the decrease in CIMT was insignificantly statistic. In DMARDs group atherosclerotic plaque was detected to 26 patients (74.29%) and 21 (46.66%) patients were detected into anti-TNF group. After 12 months CIMT was significantly higher in DMARDs group and the difference was statistically significant compared to baseline and to anti-TNF group (p=0.0002). High DAS28 score was associated with increased CIMT and hyperhomocysteinemia in both groups (p=0.0001).Conclusion:Increased Hcy levels were associated with increased CIMT values in both groups. In RA patients with anti-TNF therapy and high Hcy levels, reduction of CIMT was statistically higher than in patients with DMARDs treatment.Disclosure of Interests:None declared

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