Groove binding of indole-3-butyric acid to calf thymus DNA: Spectroscopic and in silico approaches

2021 ◽  
pp. 118323
Author(s):  
Dan Zhang ◽  
Junhui Pan ◽  
Deming Gong ◽  
Guowen Zhang
Keyword(s):  
Butyric Acid ◽  
In Silico ◽  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus

Insights into the mechanism of groove binding between 4–octylphenol and calf thymus DNA

2020 ◽  
Vol 238 ◽  
pp. 118454 ◽  
Author(s):  
Na Li ◽  
Xing Hu ◽  
Junhui Pan ◽  
Ying Zhang ◽  
Deming Gong ◽  
...  
Keyword(s):  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus

A novel view of the separate and simultaneous binding effects of docetaxel and anastrozole with calf thymus DNA: Experimental and in silico approaches

2020 ◽  
Vol 228 ◽  
pp. 117528
Author(s):  
Maryam Dareini ◽  
Zeinab Amiri Tehranizadeh ◽  
Narges Marjani ◽  
Reza Taheri ◽  
Sogand Aslani-Firoozabadi ◽  
...  
Keyword(s):  
In Silico ◽  
Calf Thymus Dna ◽  
Calf Thymus

Characterization of the groove binding between di-(2-ethylhexyl) phthalate and calf thymus DNA

2017 ◽  
Vol 101 ◽  
pp. 736-746 ◽  
Author(s):  
Song Li ◽  
Junhui Pan ◽  
Guowen Zhang ◽  
Jianjian Xu ◽  
Deming Gong
Keyword(s):  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus ◽  
Ethylhexyl Phthalate

Spectroscopic and In Silico DNA Binding Studies on the Interaction of Some New N-Substituted Rhodanines with Calf-thymus DNA: In Vitro Anticancer Activities

2019 ◽  
Vol 19 (3) ◽  
pp. 425-433 ◽  
Author(s):  
Imran Ali ◽  
Mohammad N. Lone ◽  
Zeid A. Alothman ◽  
Ahmad Y. Badjah ◽  
Abdullah G. Alanazi
Keyword(s):  
Dna Binding ◽  
Anticancer Agents ◽  
In Silico ◽  
Calf Thymus Dna ◽  
Black Dot ◽  
Anticancer Activities ◽  
Binding Studies ◽  
Molecular Docking Study ◽  
Calf Thymus ◽  
Dna Binding Studies

Background: In this era of science, cancer is a black dot on the face of humankind. Consequently, the search of promising anticancer agents continues. Aims: Here we designed and synthesized new N-substituted rhodanines (RD1-7), evaluated their multispectroscopic interaction with calf thymus DNA, in silico and anticancer studies against MDA-MB-231cancer cell line. Methods: By MTT assay rhodanine RD1 was found to be the most potent with IC50 value of 72.61 μM. In addition, DNA binding studies (UV-vis and fluorescence) revealed strong binding affinity of RD1-7 with DNA (Kb in the range of 1.5-7.4 × 105 M-1). Moreover, molecular docking study, experimental DNA binding and anticancer studies are all well agreed to each other. Results: It was observed that H-bonding and hydrophobic attractions were responsible for stability of DNAcompound adducts. Besides, the reported rhodanines (RD1-7) were found as minor groove binders of DNA. Concisely, RD1-7 indicated promising pharmacological properties and hence, shows auspicious future for the development of novel anticancer agents. Conclusion: The reported rhodanines showed excellent anticancer properties. Therefore, the described rhodanines may be used as potential anticancer agents in the future.

DUPLEX–TRIPLEX TRANSITION IN COMPLEXES OF NUCLEIC ACIDS WITH HOECHST 33258

2021 ◽  
Vol 55 (1 (254)) ◽  
pp. 39-45
Author(s):  
Marine A. Parsadanyan
Keyword(s):  
Ionic Strength ◽  
Nucleic Acids ◽  
Calf Thymus Dna ◽  
Hoechst 33258 ◽  
Groove Binding ◽  
Melting Curves ◽  
Calf Thymus ◽  
High Concentrations

The study of complexes of groove binding ligand Hoechst 33258 (H33258) with Calf Thymus DNA has been carried out. The data obtained revealed that the melting curves of the complexes of H33258 with DNA are monophasic at low ligand concentrations (0 < r ≤ 0.2) and become biphasic at relatively high concentrations (0.2 < r ≤ 0.33). This effect was revealed to depend on the ionic strength of the solution, and can also occur at high concentrations of the ligand. Comparison of the obtained data with the results for poly(rA)-poly(rU) and poly(dA)-poly(dT) shows a coincidence in the case of DNA and poly(rA)-poly(rU), while in the case of poly(dA)-poly(dT) the melting curves become biphasic at low ligand concentrations and actually do not depend on the ionic strength of the solution.

Studying the interaction of scopolamine with calf-thymus DNA: An in-vitro and in-silico approach and genotoxicity

2022 ◽  
Vol 265 ◽  
pp. 120391
Author(s):  
Faisal Ameen ◽  
Sharmin Siddiqui ◽  
Ishrat Jahan ◽  
Shahid M. Nayeem ◽  
Sayeed ur Rehman ◽  
...  
Keyword(s):  
In Silico ◽  
Calf Thymus Dna ◽  
Calf Thymus

Synthesis, structure, electrochemical, DNA interaction and antimicrobial studies of fluorinated trans-dicationic pyridinium porphyrins

RSC Advances ◽  
2016 ◽  
Vol 6 (68) ◽  
pp. 63271-63285 ◽  
Author(s):  
Jagadeesan Ramesh ◽  
Subramaniam Sujatha ◽  
Chellaiah Arunkumar
Keyword(s):  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Calf Thymus Dna ◽  
Groove Binding ◽  
Antimicrobial Studies ◽  
Calf Thymus ◽  
Artificial Nucleases

trans-Dicationic pyridinium porphyrins are superior artificial nucleases compared to their non-fluorinated analogues and bind with calf thymus DNA by outside groove binding with or without self-stacking, also show significant antimicrobial activities.

Groove Binding of Vanillin and Ethyl Vanillin to Calf Thymus DNA

2017 ◽  
Vol 27 (5) ◽  
pp. 1815-1828 ◽  
Author(s):  
Kaixin Xia ◽  
Guowen Zhang ◽  
Song Li ◽  
Deming Gong
Keyword(s):  
Calf Thymus Dna ◽  
Groove Binding ◽  
Ethyl Vanillin ◽  
Calf Thymus

Selenium nanoparticles synthesized in aqueous extract of Allium sativum perturbs the structural integrity of Calf thymus DNA through intercalation and groove binding

2017 ◽  
Vol 74 ◽  
pp. 597-608 ◽  
Author(s):  
Preedia Babu Ezhuthupurakkal ◽  
Lokeswara Rao Polaki ◽  
Arumugam Suyavaran ◽  
Ariraman Subastri ◽  
Venugopal Sujatha ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Allium Sativum ◽  
Structural Integrity ◽  
Selenium Nanoparticles ◽  
Calf Thymus Dna ◽  
Groove Binding ◽  
Calf Thymus
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