Multicomponent and 1,3-dipolar cycloaddition synthesis of triazole- and isoxazole-acridinedione/xanthenedione heterocyclic hybrids: Cytotoxic effects on human cancer cells

2020 ◽  
Vol 1217 ◽  
pp. 128325 ◽  
Author(s):  
Abdelkader Naouri ◽  
Amar Djemoui ◽  
Mouhamad Ridha Ouahrani ◽  
Mokhtar Boualem Lahrech ◽  
Najet Lemouari ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Dipolar Cycloaddition ◽  
Cytotoxic Effects ◽  
Human Cancer Cells

Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: Modulation by adrenal and gonadal steroids

2007 ◽  
Vol 104 (3-5) ◽  
pp. 228-236 ◽  
Author(s):  
Efrosini S. Katsanou ◽  
Maria Halabalaki ◽  
Nektarios Aligiannis ◽  
Sofia Mitakou ◽  
Alexios-Leandros Skaltsounis ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Gonadal Steroids ◽  
Cytotoxic Effects ◽  
Human Cancer Cells

ChemInform Abstract: Polyacetylenes from Panax stipuleanatus and Their Cytotoxic Effects on Human Cancer Cells.

ChemInform ◽  
2012 ◽  
Vol 43 (9) ◽  
pp. no-no
Author(s):  
Chun Liang ◽  
Yan Ding ◽  
Jeong Ah Kim ◽  
Seo Young Yang ◽  
Hye-Jin Boo ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cytotoxic Effects ◽  
Human Cancer Cells

Structurally related cytotoxic effects of flavonoids on human cancer cells in vitro

2008 ◽  
Vol 31 (9) ◽  
pp. 1137-1144 ◽  
Author(s):  
Hui Chang ◽  
Mantian Mi ◽  
Wenhua Ling ◽  
Jundong Zhu ◽  
Qianyong Zhang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cytotoxic Effects ◽  
Human Cancer Cells

scholarly journals Design and Synthesis of Novel Dehydroepiandrosterone Analogues as Potent Antiproliferative Agents

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2243 ◽  
Author(s):  
Xing Huang ◽  
Qing-Kun Shen ◽  
Hong-Jian Zhang ◽  
Jia-Li Li ◽  
Yu-Shun Tian ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cell Line ◽  
Human Cancer ◽  
Cytotoxic Effects ◽  
Antiproliferative Effects ◽  
Human Cancer Cells ◽  
Design And Synthesis ◽  
Ic50 Value ◽  
G2 Phase ◽  
Mcf 7

The aim of the present study was to determine the cytotoxic effects of a series of novel dehydroepiandrosterone derivatives containing triazole at the C16 position on human cancer cells. The cancer cells used in the present study were A549, Hela, HepG-2, BEL7402, MCF-7, and HCT116. Several of the synthesised compounds exhibited potent antiproliferative effects. The most promising compound was (E)-3-hydroxy-16-((1-(4-iodophenyl)-1H-1,2,3-triazole-4-yl)methylene)-10,13-dimet-hyl-1,3,4,7,8,9,10,11,12,13,15,16-dodecahydro-2H-cyclopenta[a]phenanthren-17(14)-one (compound 2n), which showed considerably high antiproliferative activity in the HepG-2 cell line, with an IC50 value of 9.10 µM, and considerably high activity against the MCF-7 cell line, with an IC50 value of 9.18 µM. Flow cytometry assays demonstrated that compound 2n exerted antiproliferative effects by arresting cells in the G2 phase of the cell cycle and inducing apoptosis.

scholarly journals Cyclin A correlates with the sensitivity of human cancer cells to cytotoxic effects of 5-FU

2004 ◽  
Author(s):  
Ryuichi Kawashima ◽  
Minoru Haisa ◽  
Masashi Kimura ◽  
Munenori Takaoka ◽  
Yasuhiro Shirakawa ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cyclin A ◽  
Cytotoxic Effects ◽  
Human Cancer Cells

Cytotoxic Effects of Ellagitannins Isolated from Walnuts in Human Cancer Cells

2014 ◽  
Vol 66 (8) ◽  
pp. 1304-1314 ◽  
Author(s):  
Vy Le ◽  
Debora Esposito ◽  
Mary H. Grace ◽  
Danny Ha ◽  
Anh Pham ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cytotoxic Effects ◽  
Human Cancer Cells
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