Epidemiology and diagnostic criteria 364
Cutaneous features of scleroderma and their treatment 368
Systemic features of the disease, investigation, and treatment 372
Antifibrotic and immunosuppressive therapies for systemic sclerosis 378
Summary—the approach to systemic sclerosis 380
Scleroderma-like fibrosing disorders 382
• Scleroderma is a spectrum of rare disorders ranging from limited to generalized, non-systemic to systemic, and environmental to autoimmune rheumatic disease. Generalized scleroderma, systemic sclerosis, predominantly affects women and is associated with production of collagen, widespread microvascular damage, and inflammation....