Effects of cisplatin and γ-irradiation on cell survival, the induction of chromosomal aberrations and apoptosis in SW-1573 cells

2006 ◽  
Vol 594 (1-2) ◽  
pp. 148-154 ◽  
Author(s):  
J.W.J. Bergs ◽  
N.A.P. Franken ◽  
R. ten Cate ◽  
C. van Bree ◽  
J. Haveman
Keyword(s):  
Cell Survival ◽  
Chromosomal Aberrations ◽  
Γ Irradiation

Prosurvival and antiapoptotic effects of PGE2in radiation injury are mediated by EP2 receptor in intestine

2003 ◽  
Vol 284 (3) ◽  
pp. G490-G498 ◽  
Author(s):  
Courtney W. Houchen ◽  
Mark A. Sturmoski ◽  
Shrikant Anant ◽  
Richard M. Breyer ◽  
William F. Stenson
Keyword(s):  
Stem Cell ◽  
Cell Survival ◽  
Cross Section ◽  
Radiation Injury ◽  
Biological Activities ◽  
Receptor Expression ◽  
Apoptotic Cells ◽  
Wild Type ◽  
Γ Irradiation ◽  
Stem Cell Survival

The biological activities of PGE2 are mediated through EP receptors (EP1–EP4), plasma membrane G protein-coupled receptors that differ in ligand binding and signal-transduction pathways. We investigated gastrointestinal EP2 receptor expression in adult mice before and after radiation injury and evaluated intestinal stem cell survival and crypt epithelial apoptosis after radiation injury in EP2 null mice. EP2 was expressed throughout the gut. Intestinal EP2 mRNA increased fivefold after γ-irradiation. Crypt survival was diminished in EP2 −/− mice (4.06 crypts/cross section) compared with wild-type littermates (8.15 crypts/cross section). Radiation-induced apoptosis was significantly increased in EP2 −/− mice compared with wild-type littermates. Apoptosis was 1.6-fold higher in EP2 −/− mice (5.9 apoptotic cells/crypt) than in wild-type mice (3.5 apoptotic cells/crypt). The EP2receptor is expressed in mouse gastrointestinal epithelial cells and is upregulated following radiation injury. The effects of PGE2on both crypt epithelial apoptosis and intestinal crypt stem cell survival are mediated through the EP2 receptor.

Cell cycle inhibitor, p19INK4d, promotes cell survival and decreases chromosomal aberrations after genotoxic insult due to enhanced DNA repair

DNA Repair ◽  
2007 ◽  
Vol 6 (5) ◽  
pp. 626-638 ◽  
Author(s):  
María E. Scassa ◽  
Mariela C. Marazita ◽  
Julieta M. Ceruti ◽  
Abel L. Carcagno ◽  
Pablo F. Sirkin ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Dna Repair ◽  
Cell Survival ◽  
Chromosomal Aberrations ◽  
Cell Cycle Inhibitor ◽  
Genotoxic Insult

scholarly journals Identification of Novel Chromosomal Aberrations Induced by 60Co-γ-Irradiation in Wheat-Dasypyrum villosum Lines

2015 ◽  
Vol 16 (12) ◽  
pp. 29787-29796 ◽  
Author(s):  
Jie Zhang ◽  
Yun Jiang ◽  
Yuanlin Guo ◽  
Guangrong Li ◽  
Zujun Yang ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Dasypyrum Villosum ◽  
Γ Irradiation

Chromosomal aberrations induced by low-dose γ-irradiation study of R-banded chromosomes of human lymphocytes

1989 ◽  
Vol 212 (2) ◽  
pp. 167-172 ◽  
Author(s):  
D. Lefrançois ◽  
W. Al Achkar ◽  
A. Aurias ◽  
J. Couturier ◽  
A.M. Dutrillaux ◽  
...  
Keyword(s):  
Chromosomal Aberrations ◽  
Low Dose ◽  
Human Lymphocytes ◽  
Γ Irradiation

Cell survival and chromosomal aberrations in CHO-K1 cells irradiated by carbon ions

2009 ◽  
Vol 67 (3) ◽  
pp. 447-453 ◽  
Author(s):  
J. Czub ◽  
D. Banaś ◽  
A. Błaszczyk ◽  
J. Braziewicz ◽  
I. Buraczewska ◽  
...  
Keyword(s):  
Cell Survival ◽  
Chromosomal Aberrations ◽  
Carbon Ions
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