scholarly journals Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein

2016 ◽  
Vol 789 ◽  
pp. 33-38 ◽  
Author(s):  
Jishen Pan ◽  
Elizabeth Sinclair ◽  
Zhuoli Xuan ◽  
Marcin Dyba ◽  
Ying Fu ◽  
...  
Keyword(s):  
Docosahexaenoic Acid ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Dna Adduct ◽  
Repair Deficiency ◽  
Nucleotide Excision

scholarly journals Variation in PAH-related DNA adduct levels among non-smokers: The role of multiple genetic polymorphisms and nucleotide excision repair phenotype

2012 ◽  
Vol 132 (12) ◽  
pp. 2738-2747 ◽  
Author(s):  
Arash Etemadi ◽  
Farhad Islami ◽  
David H. Phillips ◽  
Roger Godschalk ◽  
Asieh Golozar ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Dna Adduct ◽  
Nucleotide Excision

scholarly journals Nucleotide excision repair deficiency in melanoma in response to UVA

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Heather C. Murray ◽  
Vicki E. Maltby ◽  
Doug W. Smith ◽  
Nikola A. Bowden
Keyword(s):  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Repair Deficiency ◽  
Nucleotide Excision

scholarly journals Nucleotide excision repair deficiency is intrinsic in sporadic stage I breast cancer

2010 ◽  
Vol 107 (50) ◽  
pp. 21725-21730 ◽  
Author(s):  
J. J. Latimer ◽  
J. M. Johnson ◽  
C. M. Kelly ◽  
T. D. Miles ◽  
K. A. Beaudry-Rodgers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nucleotide Excision Repair ◽  
Excision Repair ◽  
Stage I ◽  
Repair Deficiency ◽  
Nucleotide Excision

scholarly journals Cryo-EM structure of TFIIH/Rad4–Rad23–Rad33 in damaged DNA opening in nucleotide excision repair

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Trevor van Eeuwen ◽  
Yoonjung Shim ◽  
Hee Jong Kim ◽  
Tingting Zhao ◽  
Shrabani Basu ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Genomic Dna ◽  
Excision Repair ◽  
Dna Lesions ◽  
Dna Adduct ◽  
Dna Unwinding ◽  
General Transcription Factor ◽  
Nucleotide Excision ◽  
Torque Generation ◽  
Transcription Factor Complex

AbstractThe versatile nucleotide excision repair (NER) pathway initiates as the XPC–RAD23B–CETN2 complex first recognizes DNA lesions from the genomic DNA and recruits the general transcription factor complex, TFIIH, for subsequent lesion verification. Here, we present a cryo-EM structure of an NER initiation complex containing Rad4–Rad23-Rad33 (yeast homologue of XPC–RAD23B–CETN2) and 7-subunit coreTFIIH assembled on a carcinogen-DNA adduct lesion at 3.9–9.2 Å resolution. A ~30-bp DNA duplex could be mapped as it straddles between Rad4 and the Ssl2 (XPB) subunit of TFIIH on the 3' and 5' side of the lesion, respectively. The simultaneous binding with Rad4 and TFIIH was permitted by an unwinding of DNA at the lesion. Translocation coupled with torque generation by Ssl2 and Rad4 would extend the DNA unwinding at the lesion and deliver the damaged strand to Rad3 (XPD) in an open form suitable for subsequent lesion scanning and verification.

scholarly journals Adenine-DNA Adduct Derived from the Nitroreduction of 6-Nitrochrysene Is More Resistant to Nucleotide Excision Repair than Guanine-DNA Adducts

2013 ◽  
Vol 26 (11) ◽  
pp. 1746-1754 ◽  
Author(s):  
Jacek Krzeminski ◽  
Konstantin Kropachev ◽  
Dara Reeves ◽  
Aleksandr Kolbanovskiy ◽  
Marina Kolbanovskiy ◽  
...  
Keyword(s):  
Nucleotide Excision Repair ◽  
Dna Adducts ◽  
Excision Repair ◽  
Dna Adduct ◽  
Nucleotide Excision
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