Trichlorfon predisposes to aneuploidy and interferes with spindle formation in in vitro maturing mouse oocytes

2004 ◽  
Vol 564 (2) ◽  
pp. 165-178 ◽  
Author(s):  
Suna Cukurcam ◽  
Fengyun Sun ◽  
Ilse Betzendahl ◽  
Ilse-Dore Adler ◽  
Ursula Eichenlaub-Ritter
Keyword(s):  
Spindle Formation ◽  
Mouse Oocytes

Perfluorooctanoic acid inhibits the maturation rate of mouse oocytes cultured in vitro by triggering mitochondrial and DNA damage

2021 ◽  
Author(s):  
Conghui Guo ◽  
Zhihong Zhao ◽  
Kun Zhao ◽  
Jianhao Huang ◽  
Linshu Ding ◽  
...  
Keyword(s):  
Dna Damage ◽  
Perfluorooctanoic Acid ◽  
Mouse Oocytes ◽  
Maturation Rate

scholarly journals WHAMM is essential for spindle formation and spindle actin polymerization in maturing mouse oocytes

Cell Cycle ◽  
2021 ◽  
pp. 1-11
Author(s):  
Yu-Jin Jo ◽  
Jeongwoo Kwon ◽  
Zhe-Long Jin ◽  
Suk Namgoong ◽  
Taeho Kwon ◽  
...  
Keyword(s):  
Actin Polymerization ◽  
Spindle Formation ◽  
Mouse Oocytes

scholarly journals R-066. Cytoskeletal and cytogenetic abnormalities during the in-vitro maturation of mouse oocytes exposed to cocaine

1999 ◽  
Vol 14 (Suppl_3) ◽  
pp. 308-308
Author(s):  
C.M.H. Combelles ◽  
M.J. Carabatsos ◽  
J.B. Mailhes ◽  
S.N. London ◽  
D.F. Albertini
Keyword(s):  
In Vitro Maturation ◽  
Cytogenetic Abnormalities ◽  
Mouse Oocytes

Conditions that affect acquisition of developmental competence by mouse oocytes in vitro: FSH, insulin, glucose and ascorbic acid

2000 ◽  
Vol 163 (1-2) ◽  
pp. 109-116 ◽  
Author(s):  
John J Eppig ◽  
Misa Hosoe ◽  
Marilyn J O’Brien ◽  
Frank M Pendola ◽  
Antonio Requena ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Developmental Competence ◽  
Mouse Oocytes

Triphenyltin chloride induces spindle microtubule depolymerisation and inhibits meiotic maturation in mouse oocytes

2014 ◽  
Vol 26 (8) ◽  
pp. 1084 ◽  
Author(s):  
Yu-Ting Shen ◽  
Yue-Qiang Song ◽  
Xiao-Qin He ◽  
Fei Zhang ◽  
Xin Huang ◽  
...  
Keyword(s):  
Polar Body ◽  
Meiotic Maturation ◽  
Dependent Manner ◽  
Germinal Vesicle Breakdown ◽  
Mouse Oocytes ◽  
First Polar Body ◽  
Triphenyltin Chloride ◽  
Dose Dependent

Meiosis produces haploid gametes for sexual reproduction. Triphenyltin chloride (TPTCL) is a highly bioaccumulated and toxic environmental oestrogen; however, its effect on oocyte meiosis remains unknown. We examined the effect of TPTCL on mouse oocyte meiotic maturation in vitro and in vivo. In vitro, TPTCL inhibited germinal vesicle breakdown (GVBD) and first polar body extrusion (PBE) in a dose-dependent manner. The spindle microtubules completely disassembled and the chromosomes condensed after oocytes were exposed to 5 or 10 μg mL–1 TPTCL. γ-Tubulin protein was abnormally localised near chromosomes rather than on the spindle poles. In vivo, mice received TPTCL by oral gavage for 10 days. The general condition of the mice deteriorated and the ovary coefficient was reduced (P < 0.05). The number of secondary and mature ovarian follicles was significantly reduced by 10 mg kg–1 TPTCL (P < 0.05). GVBD decreased in a non-significant, dose-dependent manner (P > 0.05). PBE was inhibited with 10 mg kg–1 TPTCL (P < 0.05). The spindles of in vitro and in vivo metaphase II oocytes were disassembled with 10 mg kg–1 TPTCL. These results suggest that TPTCL seriously affects meiotic maturation by disturbing cell-cycle progression, disturbing the microtubule cytoskeleton and inhibiting follicle development in mouse oocytes.

scholarly journals Cytochalasin B-induced triploidy in mouse oocytes fertilized in vitro

Reproduction ◽  
1976 ◽  
Vol 48 (2) ◽  
pp. 279-284 ◽  
Author(s):  
A. Niemierko ◽  
A. Komar
Keyword(s):  
Cytochalasin B ◽  
Mouse Oocytes

scholarly journals RNA-Seq transcriptome profiling of mouse oocytes after in vitro maturation and/or vitrification

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Lei Gao ◽  
Gongxue Jia ◽  
Ai Li ◽  
Haojia Ma ◽  
Zhengyuan Huang ◽  
...  
Keyword(s):  
In Vitro Maturation ◽  
Transcriptome Profiling ◽  
Rna Seq ◽  
Mouse Oocytes

scholarly journals Mouse oocytes derived from fetal germ cells are competent to support the development of embryos by in vitro fertilization

2008 ◽  
Vol 75 (11) ◽  
pp. 1688-1689
Author(s):  
Wei Shen ◽  
Lan Li ◽  
Donghui Zhang ◽  
Qingjie Pan ◽  
Mingxiao Ding ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Germ Cells ◽  
Vitro Fertilization ◽  
Mouse Oocytes
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