Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption

Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer.

Download Full-text

Association between single nucleotide polymorphisms in the XRCC1 and RAD51 genes and clinical radiosensitivity in head and neck cancer

Radiotherapy and Oncology ◽

10.1016/j.radonc.2011.05.062 ◽

2011 ◽

Vol 99 (3) ◽

pp. 356-361 ◽

Cited By ~ 57

Author(s):

Nicola Pratesi ◽

Monica Mangoni ◽

Irene Mancini ◽

Fabiola Paiar ◽

Lisa Simi ◽

...

Keyword(s):

Head And Neck Cancer ◽

Single Nucleotide Polymorphisms ◽

Head And Neck ◽

Neck Cancer ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Clinical Radiosensitivity

Download Full-text

Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer

Future Oncology ◽

10.2217/fon-2019-0365 ◽

2019 ◽

Vol 15 (33) ◽

pp. 3819-3829

Author(s):

Malik Waqar Ahmed ◽

Ishrat Mahjabeen ◽

Shazma Gul ◽

Anum Khursheed ◽

Azhar Mehmood ◽

...

Keyword(s):

Head And Neck Cancer ◽

Single Nucleotide Polymorphisms ◽

Head And Neck ◽

Unfolded Protein Response ◽

Neck Cancer ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Unfolded Protein ◽

Protein Response ◽

Mitochondrial Unfolded Protein Response

Aim: In this study, we evaluated the effect of selected polymorphisms of mitochondrial unfolded protein response (UPRmt) pathway in 500 head and neck cancer (HNC) patients and 500 healthy controls from Pakistan. Materials & methods: The experiments were conducted using tetra-ARMS PCR followed by DNA sequencing. Results: Multivariate analysis showed that AA genotype of rs3782116 showed fivefold, GG genotype of rs6598072 approximately twofold and CC genotype of rs4946936 and TT genotype of rs12212067 showed twofold increased risk of HNC. Furthermore, haplotype analysis showed that certain haplotypes of UPRmt pathway single nucleotide polymorphisms have significant association with increased HNC risk. Conclusion: These results show that genetic aberrations in UPRmt pathway genes have association with increased HNC risk and can be an indicator of advance clinical outcome especially invasion and metastasis.

Download Full-text