Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk+/− cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action

2010 ◽  
Vol 702 (2) ◽  
pp. 193-198 ◽  
Author(s):  
Stephan Kirchner ◽  
Andreas Zeller
Keyword(s):  
Mitomycin C ◽  
Mode Of Action ◽  
Micronucleus Test

scholarly journals Plasma disposition and in vivo and in vitro antiumor activities of mitomycin C-dextran conjugate in relation to the mode of action.

1985 ◽  
Vol 33 (7) ◽  
pp. 2941-2947 ◽  
Author(s):  
SATOSHI MATSUMOTO ◽  
YOSHIKO ARASE ◽  
YOSHINOBU TAKAKURA ◽  
MITSURU HASHIDA ◽  
HITOSHI SEZAKI
Keyword(s):  
Mitomycin C ◽  
Mode Of Action ◽  
Dextran Conjugate

In vitro Cytotoxicity and Genotoxicity Analysis of Ten Tannery Chemicals Using SOS/umu Tests and High-content In vitro Micronucleus Tests

2018 ◽  
Vol 21 (4) ◽  
pp. 262-270 ◽  
Author(s):  
Zehao Huang ◽  
Na Li ◽  
Kaifeng Rao ◽  
Cuiting Liu ◽  
Zijian Wang ◽  
...  
Keyword(s):  
Micronucleus Test ◽  
A549 Cells ◽  
Quantitative Structure Activity Relationship ◽  
In Vitro Cytotoxicity ◽  
Cytotoxic Effects ◽  
Qsar Analysis ◽  
Cell Assays ◽  
Micronucleus Tests ◽  
Damaging Effects

Background: More than 2,000 chemicals have been used in the tannery industry. Although some tannery chemicals have been reported to have harmful effects on both human health and the environment, only a few have been subjected to genotoxicity and cytotoxicity evaluations. Objective: This study focused on cytotoxicity and genotoxicity of ten tannery chemicals widely used in China. Materials and Methods: DNA-damaging effects were measured using the SOS/umu test with Salmonella typhimurium TA1535/pSK1002. Chromosome-damaging and cytotoxic effects were determined with the high-content in vitro Micronucleus test (MN test) using the human-derived cell lines MGC-803 and A549. Conclusion: The cytotoxicity of the ten tannery chemicals differed somewhat between the two cell assays, with A549 cells being more sensitive than MGC-803 cells. None of the chemicals induced DNA damage before metabolism, but one was found to have DNA-damaging effects on metabolism. Four of the chemicals, DY64, SB1, DB71 and RR120, were found to have chromosome-damaging effects. A Quantitative Structure-Activity Relationship (QSAR) analysis indicated that one structural feature favouring chemical genotoxicity, Hacceptor-path3-Hacceptor, may contribute to the chromosome-damaging effects of the four MN-test-positive chemicals.

scholarly journals The effect of platelet-rich fibrin on normal dermal fibroblast proliferation after mitomycin-c treatment: An in vitro study

2021 ◽  
Vol 62 ◽  
pp. 473-476
Author(s):  
Ishandono Dachlan ◽  
Hendy Satrya Kurniawan ◽  
Aditya Wicaksana ◽  
Aditya Rifqi Fauzi ◽  
Firdian Makrufardi ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Dermal Fibroblast ◽  
In Vitro Study ◽  
Vitro Study ◽  
Fibroblast Proliferation ◽  
Platelet Rich Fibrin

scholarly journals The Mode of Action of Dibutyryl Adenosine 3′,5′-Monophosphate on Bone Tissue in Vitro

1971 ◽  
Vol 246 (22) ◽  
pp. 6770-6775
Author(s):  
Johannes N.M. Heersche ◽  
Susan A. Fedak ◽  
G.D. Aurbach
Keyword(s):  
Bone Tissue ◽  
Mode Of Action
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