Cerebral aggregate g-ratio mapping using magnetic resonance relaxometry and diffusion tensor imaging to investigate sex and age-related differences in white matter microstructure

2021 ◽  
Author(s):  
Luis E. Cortina ◽  
Richard W. Kim ◽  
Matthew Kiely ◽  
Curtis Triebswetter ◽  
Zhaoyuan Gong ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Age Related ◽  
White Matter Microstructure ◽  
G Ratio ◽  
And Diffusion

scholarly journals Brain Substrates of Time-Based Prospective Memory Decline in Aging: A Voxel-Based Morphometry and Diffusion Tensor Imaging Study

2020 ◽  
Vol 31 (1) ◽  
pp. 396-409
Author(s):  
Alexandrine Morand ◽  
Shailendra Segobin ◽  
Grégory Lecouvey ◽  
Julie Gonneaud ◽  
Francis Eustache ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Prospective Memory ◽  
Gray Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Age Related ◽  
Young Subjects ◽  
Anterior Prefrontal Cortex ◽  
And Diffusion

Abstract Time-based prospective memory (TBPM) allows us to remember to perform intended actions at a specific time in the future. TBPM is sensitive to the effects of age, but the neural substrates of this decline are still poorly understood. The aim of the present study was thus to better characterize the brain substrates of the age-related decline in TBPM, focusing on macrostructural gray matter and microstructural white matter integrity. We administered a TBPM task to 22 healthy young (26 ± 5.2 years) and 23 older (63 ± 5.9 years) participants, who also underwent volumetric magnetic resonance imaging and diffusion tensor imaging scans. Neuroimaging analyses revealed lower gray matter volumes in several brain areas in older participants, but these did not correlate with TBPM performance. By contrast, an age-related decline in fractional anisotropy in several white-matter tracts connecting frontal and occipital regions did correlate with TBPM performance, whereas there was no significant correlation in healthy young subjects. According to the literature, these tracts are connected to the anterior prefrontal cortex and the thalamus, 2 structures involved in TBPM. These results confirm the view that a disconnection process occurs in aging and contributes to cognitive decline.

Age-related alterations in white matter microstructure measured by diffusion tensor imaging

2005 ◽  
Vol 26 (8) ◽  
pp. 1215-1227 ◽  
Author(s):  
D.H. Salat ◽  
D.S. Tuch ◽  
D.N. Greve ◽  
A.J.W. van der Kouwe ◽  
N.D. Hevelone ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Age Related ◽  
White Matter Microstructure

White matter differences in euthymic bipolar I disorder: a combined magnetic resonance imaging and diffusion tensor imaging voxel-based study

2013 ◽  
Vol 15 (4) ◽  
pp. 365-376 ◽  
Author(s):  
Louise Emsell ◽  
Camilla Langan ◽  
Wim Van Hecke ◽  
Gareth J Barker ◽  
Alexander Leemans ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Resonance Imaging ◽  
Bipolar I Disorder ◽  
And Diffusion

scholarly journals Characterization of white matter alterations in phenylketonuria by magnetic resonance relaxometry and diffusion tensor imaging

2007 ◽  
Vol 58 (6) ◽  
pp. 1145-1156 ◽  
Author(s):  
Peter Vermathen ◽  
Laure Robert-Tissot ◽  
Joachim Pietz ◽  
Thomas Lutz ◽  
Chris Boesch ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
And Diffusion

scholarly journals Dimensions of Attention Associated With the Microstructure of Corona Radiata White Matter

2017 ◽  
Vol 32 (5) ◽  
pp. 458-466 ◽  
Author(s):  
Elise A. Stave ◽  
Michael D. De Bellis ◽  
Steven R. Hooper ◽  
Donald P. Woolley ◽  
Suk Ki Chang ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Neural Correlates ◽  
Neural Correlate ◽  
Corona Radiata ◽  
White Matter Microstructure ◽  
Neuropsychological Assessments ◽  
Pearson Correlations ◽  
And Diffusion

Mirsky proposed a model of attention that included these dimensions: focus/execute, sustain, stabilize, encode, and shift. The neural correlates of these dimensions were investigated within corona radiata subregions in healthy youth. Diffusion tensor imaging and neuropsychological assessments were conducted in 79 healthy, right-handed youth aged 4-17 years. Diffusion tensor imaging maps were analyzed using standardized parcellation methods. Partial Pearson correlations between neuropsychological standardized scores, representing these attention dimensions, and diffusion tensor imaging measures of corona radiata subregions were calculated after adjusting for gender and IQ. Significant correlations were found between the focus/execute, sustain, stabilize, and shift dimensions and imaging metrics in hypothesized corona radiata subregions. Results suggest that greater microstructural white matter integrity of the corona radiata is partly associated with attention across 4 attention dimensions. Findings suggest that white matter microstructure of the corona radiata is a neural correlate of several, but not all, attention dimensions.

Sign in / Sign up

Export Citation Format

Share Document