scholarly journals Validation of the Guy's Neurological Disability Scale as a screening tool for cognitive impairment in multiple sclerosis

2019 ◽  
Vol 35 ◽  
pp. 272-275
Author(s):  
Ritsu Akatani ◽  
Norio Chihara ◽  
Hisatsugu Tachibana ◽  
Shusuke Koto ◽  
Hisatomo Kowa ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Screening Tool ◽  
Neurological Disability ◽  
Disability Scale

Factor structure of Guy’s Neurological Disability Scale in a sample of Dutch patients with multiple sclerosis

2011 ◽  
Vol 17 (12) ◽  
pp. 1498-1503 ◽  
Author(s):  
LB Mokkink ◽  
DL Knol ◽  
BMJ Uitdehaag
Keyword(s):  
Multiple Sclerosis ◽  
Factor Structure ◽  
General Factor ◽  
Cronbach’S Alpha ◽  
Neurological Disability ◽  
Structural Validity ◽  
Cronbach's Alpha ◽  
Disability Scale ◽  
Scale Scores ◽  
Item Factor Analysis

Background: Guy’s Neurological Disability Scale (GNDS) is designed to assess disability (i.e. activity limitations) in patients with multiple sclerosis. It contains 12 functional domains, each indicating a level of disability. Four domain scores and a total score can be calculated. Objective: The aim of this study was to evaluate the structural validity of the GNDS in a Dutch population who were definitely diagnosed as having multiple sclerosis. Methods: Data of 974 patients were available. The structural validity of the GNDS was evaluated by confirmatory item factor analysis (CIFA). Two first-order models and two bifactor models were investigated. Results: The best fitted model was a bifactor model with a general factor underlying all items, and 10 items loading on 3 group factors. Cronbach’s alpha on the general factor (0.78) and on the group factor spinal-plus (0.74) were satisfying. Cronbach’s alpha on the group factors mental (0.56) and bulbar (0.48) were low. Reliability based on CIFA was 0.85. Conclusion: Results showed a clear factor structure of the GNDS. It justifies the use of the total score of the GNDS. In addition, three sub-scale scores could be used.

A short version of Rao's Brief Repeatable Battery as a screening tool for cognitive impairment in multiple sclerosis

2009 ◽  
Vol 23 (2) ◽  
pp. 268-275 ◽  
Author(s):  
E. Portaccio ◽  
B. Goretti ◽  
V. Zipoli ◽  
G. Siracusa ◽  
S. Sorbi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Screening Tool ◽  
Short Version ◽  
Repeatable Battery

scholarly journals Validation of the brazilian version of Guy's neurological disability scale

2007 ◽  
Vol 65 (3a) ◽  
pp. 615-618 ◽  
Author(s):  
Carolina R. Araujo ◽  
Luciano M. Simão ◽  
Mariana I. Ybarra ◽  
Natasha V.M.G. Faria ◽  
Caroline M. Botelho ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Intraclass Correlation ◽  
Neurological Disability ◽  
Factor Solution ◽  
Disability Scale ◽  
Brazilian Version ◽  
Definite Multiple Sclerosis ◽  
Back Translation ◽  
Clinically Definite Multiple Sclerosis ◽  
Translation Methodology

The Guy's neurological disability scale (GNDS) has recently been introduced as a new measure of disability in multiple sclerosis. It is patient-oriented, multidimensional, and not biased towards any particular disability. The purpose of the present study was to validate the Brazilian version of the GNDS. The adaptation of the scale was based on the translation/back-translation methodology. Sixty-two patients with clinically definite multiple sclerosis (CDMS) according to Poser's criteria were recruited for this study. GNDS was administered individually to each subject. The EDSS and the ambulation index (AI) scores were assigned by a neurologist. The intraclass correlation coefficient and the Cronbach's alpha values of the Brazilian version of GNDS (0.94 and 0.83, respectively) were comparable to the original one (0.98 and 0.79, respectively). Furthermore, the factor analysis of the Brazilian version of GNDS suggested, as the original article, a four-factor solution which accounted for 68.8% of the total variance. The Brazilian version of GNDS was found to be clinically relevant as it correlated significantly with the EDSS and AI. In conclusion, the Brazilian version of GNDS can be considered an important tool to evaluate the disability in MS patients, with clinical usefulness and psychometrics soundness.

The brief neuropsychological battery for children: a screening tool for cognitive impairment in childhood and juvenile multiple sclerosis

2009 ◽  
Vol 15 (5) ◽  
pp. 620-626 ◽  
Author(s):  
E Portaccio ◽  
B Goretti ◽  
S Lori ◽  
V Zipoli ◽  
S Centorrino ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Screening Tool ◽  
Preliminary Evidence ◽  
Neuropsychological Battery ◽  
Selective Reminding ◽  
Trail Making ◽  
Selective Reminding Test ◽  
Age Range ◽  
Cognitive Problems

Background A critical problem with neuropsychological assessment in children and adolescents with multiple sclerosis (MS) is the absence of a standardized, well-validated neuropsychological battery specifically tailored for detecting disease-related cognitive problems in this age range. Objective To develop a Brief Neuropsychological Battery for Children (BNBC) with MS. Methods We assessed cognitive functions in 61 patients with childhood and juvenile MS and 58 demographically matched healthy controls through an extensive neuropsychological battery. Results In MS patients, we found a proportion of cognitive impairment of 41%. In the BNBC, we included the tests with higher discriminating ability (the Selective Reminding Test, the Symbol Digit Modalities Test, the Trail Making Test, and the Vocabulary test from the Wechsler Intelligence Scale for children). The BNBC yielded a sensitivity of 96% and a specificity of 76%. Conclusion Our findings provide preliminary evidence of the usefulness of the BNBC as a screening tool for detecting cognitive impairment in childhood and juvenile MS cases.

Rapid cognitive screening in multiple sclerosis accomplished by the Free Recall and Recognition Test

2007 ◽  
Vol 13 (2) ◽  
pp. 272-274 ◽  
Author(s):  
Im Claesson ◽  
C Ytterberg ◽  
S Johansson ◽  
O Almkvist ◽  
L Von Koch
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Free Recall ◽  
Disease Severity ◽  
Recognition Test ◽  
Screening Tool ◽  
Cognitive Tests ◽  
Cognitive Screening ◽  
Severity Rating ◽  
Serial Addition

This study sought to investigate the feasibility of the Free Recall and Recognition Test (FRRT) as a practical screening tool for cognitive impairment in multiple sclerosis (MS). Persons with MS (n =227) were consecutively recruited and assessed with four cognitive tests; FRRT, Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and the Mini-Mental State Examination (MMSE). Disease severity was assessed by the Expanded Disability Status Scale (EDSS). The FRRT, which was completed by 99% of the cohort in approximately 5 minutes per assessment, correlated significantly with the other cognitive tests, as well as with the disease severity rating. A cut-off of 4 for the FRRT recall rendered 90% sensitivity and 25% specificity, and a cut-off of 4.2 for the FRRT recognition resulted in 70% sensitivity and 51% specificity. We conclude that the FRRT proved feasible as a practical screening tool for cognitive impairment in MS within a clinical setting. Multiple Sclerosis 2007; 13: 272–274. http://msj.sagepub.com

The Guy's Neurological Disability Scale (GNDS): a new disability measure for multiple sclerosis

1999 ◽  
Vol 5 (4) ◽  
pp. 223-233 ◽  
Author(s):  
Basil Sharrack ◽  
Richard AC Hughes
Keyword(s):  
Multiple Sclerosis ◽  
Bowel Function ◽  
Postal Questionnaire ◽  
Postal Survey ◽  
Bladder Function ◽  
Neurological Disability ◽  
Limb Function ◽  
Upper Limb Function ◽  
Disability Scale ◽  
User Friendly

A postal survey showed that the majority of 49 leading international neurologists involved with multiple sclerosis research felt that currently existing outcome measures for this illness were inadequate, and that there was a need for a new measure which should be patient orientated, multidimensional, and not biased towards any particular disability. The Guy's Neurological Disability Scale (GNDS) was subsequently devised as a simple and user-friendly clinical disability scale capable of embracing the whole range of disabilities which could be encountered in the course of multiple sclerosis. It has 12 separate categories which include cognition, mood, vision, speech, swallowing, upper limb function, lower limb function, bladder function, bowel function, sexual function, fatigue, and `others'. The GNDS was found to be acceptable to neurologists and patients, reliable, responsive, and valid as a measure of disability. The scale was also found to be valid when applied by non-neurologists, over the phone, or via a postal questionnaire.

scholarly journals Staging and stratifying cognitive dysfunction in multiple sclerosis

2021 ◽  
pp. 135245852110113
Author(s):  
Curtis Wojcik ◽  
Tom A Fuchs ◽  
Hoan Tran ◽  
Michael G Dwyer ◽  
Dejan Jakimovski ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Processing Speed ◽  
Visual Learning ◽  
Verbal Learning ◽  
Neurological Disability ◽  
Disease Evolution ◽  
Cognitive Domains ◽  
Consensus Standard

Background: The sequence in which cognitive domains become impaired in multiple sclerosis (MS) is yet to be formally demonstrated. It is unclear whether processing speed dysfunction temporally precedes other cognitive impairments, such as memory and executive function. Objective: Determine the order in which different cognitive domains become impaired in MS and validate these findings using clinical and vocational outcomes. Methods: In a longitudinal sample of 1073 MS patients and 306 healthy controls, we measured performance on multiple, consensus-standard, neurocognitive tests. We used an event-based staging approach to model the sequence in which cognitive domains become impaired. Linear and logistic mixed-effects models were used to explore associations between stages of impairment, neurological disability, and employment status. Results: Our model suggested that the order of impairments was as follows: processing speed, visual learning, verbal learning, working memory/attention, and executive function. Stage of cognitive impairment predicted greater neurological disability, β = 0.16, SE = 0.02, p < 0.001, and probability of unemployment, β = 1.14, SE = 0.001, p < 0.001. Conclusion: This is the first study to introduce a cognitive staging and stratification system for MS. Findings underscore the importance of using the Symbol Digit Modalities Test in routine screening for cognitive impairment and memory testing to assess patients later in disease evolution.

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