Micropatterned coculture of hepatocytes on electrospun fibers as a potential in vitro model for predictive drug metabolism

2016 ◽  
Vol 63 ◽  
pp. 475-484 ◽  
Author(s):  
Yaowen Liu ◽  
Jiaojun Wei ◽  
Jinfu Lu ◽  
Dongmei Lei ◽  
Shili Yan ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Electrospun Fibers ◽  
Vitro Model

scholarly journals Crypt Organoid Culture as an In Vitro Model in Drug Metabolism and Cytotoxicity Studies

2017 ◽  
Vol 45 (7) ◽  
pp. 748-754 ◽  
Author(s):  
Wenqi Lu ◽  
Eva Rettenmeier ◽  
Miles Paszek ◽  
Mei-Fei Yueh ◽  
Robert H. Tukey ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Organoid Culture ◽  
Cytotoxicity Studies ◽  
Vitro Model

Hepatocyte spheroid culture on fibrous scaffolds with grafted functional ligands as an in vitro model for predicting drug metabolism and hepatotoxicity

2015 ◽  
Vol 28 ◽  
pp. 138-148 ◽  
Author(s):  
Shili Yan ◽  
Jiaojun Wei ◽  
Yaowen Liu ◽  
Hong Zhang ◽  
Jianmei Chen ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Spheroid Culture ◽  
Fibrous Scaffolds ◽  
Hepatocyte Spheroid ◽  
Vitro Model

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

2008 ◽  
Vol 36 (7) ◽  
pp. 1444-1452 ◽  
Author(s):  
Kajsa P. Kanebratt ◽  
Tommy B. Andersson
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Heparg Cells ◽  
Vitro Model

scholarly journals Recellularization of rat liver: An in vitro model for assessing human drug metabolism and liver biology

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0191892 ◽  
Author(s):  
Matthew J. Robertson ◽  
Benjamin Soibam ◽  
Jacqueline G. O’Leary ◽  
Luiz C. Sampaio ◽  
Doris A. Taylor
Keyword(s):  
Drug Metabolism ◽  
Rat Liver ◽  
In Vitro Model ◽  
Vitro Model

Spheroid culture of primary hepatocytes with short fibers as a predictable in vitro model for drug screening

2016 ◽  
Vol 4 (44) ◽  
pp. 7155-7167 ◽  
Author(s):  
Jiaojun Wei ◽  
Jinfu Lu ◽  
Yaowen Liu ◽  
Shili Yan ◽  
Xiaohong Li
Keyword(s):  
Drug Metabolism ◽  
Drug Screening ◽  
In Vitro Model ◽  
Short Fibers ◽  
Primary Hepatocytes ◽  
Spheroid Culture ◽  
Vitro Model ◽  
Hepatocyte Spheroids ◽  
Size Controlled

Short fibers are utilized as scaffolds for generation of size-controlled hepatocyte spheroids, exhibiting an efficient in vitro model for determining drug metabolism.

scholarly journals Aggregate Culture of Human Embryonic Stem Cell-Derived Hepatocytes in Suspension Are an Improved In Vitro Model for Drug Metabolism and Toxicity Testing

2014 ◽  
Vol 140 (1) ◽  
pp. 236-245 ◽  
Author(s):  
Srikumar Sengupta ◽  
Brian Patrick Johnson ◽  
Scott Allen Swanson ◽  
Ron Stewart ◽  
Christopher Alan Bradfield ◽  
...  
Keyword(s):  
Stem Cell ◽  
Drug Metabolism ◽  
Embryonic Stem Cell ◽  
Human Embryonic Stem Cell ◽  
In Vitro Model ◽  
Embryonic Stem ◽  
Toxicity Testing ◽  
Aggregate Culture ◽  
Vitro Model

CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION*

2000 ◽  
Vol 32 (1) ◽  
pp. 81-118 ◽  
Author(s):  
JAN G. HENGSTLER ◽  
D. UTESCH ◽  
P. STEINBERG ◽  
K. L. PLATT ◽  
B. DIENER ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
Enzyme Induction ◽  
In Vitro Model ◽  
Primary Hepatocytes ◽  
Vitro Model

An in vitro model for investigation of vitamin A effects on wound healing

2021 ◽  
pp. 1-6
Author(s):  
Hoda Keshmiri Neghab ◽  
Mohammad Hasan Soheilifar ◽  
Gholamreza Esmaeeli Djavid
Keyword(s):  
Wound Healing ◽  
Endothelial Cell ◽  
Vitamin A ◽  
In Vitro Model ◽  
Cellular Proliferation ◽  
Endothelial Cell Migration ◽  
Normal Fibroblast ◽  
Anti Inflammatory ◽  
Vitro Model

Abstract. Wound healing consists of a series of highly orderly overlapping processes characterized by hemostasis, inflammation, proliferation, and remodeling. Prolongation or interruption in each phase can lead to delayed wound healing or a non-healing chronic wound. Vitamin A is a crucial nutrient that is most beneficial for the health of the skin. The present study was undertaken to determine the effect of vitamin A on regeneration, angiogenesis, and inflammation characteristics in an in vitro model system during wound healing. For this purpose, mouse skin normal fibroblast (L929), human umbilical vein endothelial cell (HUVEC), and monocyte/macrophage-like cell line (RAW 264.7) were considered to evaluate proliferation, angiogenesis, and anti-inflammatory responses, respectively. Vitamin A (0.1–5 μM) increased cellular proliferation of L929 and HUVEC (p < 0.05). Similarly, it stimulated angiogenesis by promoting endothelial cell migration up to approximately 4 fold and interestingly tube formation up to 8.5 fold (p < 0.01). Furthermore, vitamin A treatment was shown to decrease the level of nitric oxide production in a dose-dependent effect (p < 0.05), exhibiting the anti-inflammatory property of vitamin A in accelerating wound healing. These results may reveal the therapeutic potential of vitamin A in diabetic wound healing by stimulating regeneration, angiogenesis, and anti-inflammation responses.

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