scholarly journals Human Enterocytes as an In Vitro Model for the Evaluation of Intestinal Drug Metabolism: Characterization of Drug-Metabolizing Enzyme Activities of Cryopreserved Human Enterocytes from Twenty-Four Donors

2017 ◽  
Vol 45 (6) ◽  
pp. 686-691 ◽  
Author(s):  
Ming-Chih David Ho ◽  
Nicholas Ring ◽  
Kirsten Amaral ◽  
Utkarsh Doshi ◽  
Albert P. Li
Keyword(s):  
Drug Metabolism ◽  
Enzyme Activities ◽  
In Vitro Model ◽  
Drug Metabolizing Enzyme ◽  
Vitro Model ◽  
Metabolizing Enzyme

scholarly journals Crypt Organoid Culture as an In Vitro Model in Drug Metabolism and Cytotoxicity Studies

2017 ◽  
Vol 45 (7) ◽  
pp. 748-754 ◽  
Author(s):  
Wenqi Lu ◽  
Eva Rettenmeier ◽  
Miles Paszek ◽  
Mei-Fei Yueh ◽  
Robert H. Tukey ◽  
...  
Keyword(s):  
Drug Metabolism ◽  
In Vitro Model ◽  
Organoid Culture ◽  
Cytotoxicity Studies ◽  
Vitro Model

Characterization of the mechanisms of electrochemotherapy in an in vitro model for human cervical cancer

2005 ◽  
Author(s):  
Bujian Tang ◽  
Li Li ◽  
Zhifeng Jiang ◽  
Yingzi Luan ◽  
Danrong Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
In Vitro Model ◽  
Vitro Model ◽  
Human Cervical Cancer

scholarly journals Establishment and Characterization of an In Vitro Model of Fas-Mediated Hepatocyte Cell Death

2014 ◽  
pp. 95-103
Author(s):  
Mathieu Vinken ◽  
Michaël Maes ◽  
Sara Crespo Yanguas ◽  
Joost Willebrords ◽  
Tamara Vanhaecke ◽  
...  
Keyword(s):  
Cell Death ◽  
In Vitro Model ◽  
Vitro Model

Characterization of chaotropic effects of detergents on lipids homeostasis in an in vitro model of ocular toxicity: a molecular network based-lipidomic approach

2021 ◽  
Vol 350 ◽  
pp. S129-S130
Author(s):  
R Magny ◽  
K. Kessal ◽  
A. Regazzetti ◽  
O. Laprévote ◽  
C. Baudouin ◽  
...  
Keyword(s):  
In Vitro Model ◽  
Molecular Network ◽  
Ocular Toxicity ◽  
Vitro Model

Characterization of secretomes from a human blood brain barrier endothelial cells in-vitro model after ischemia by stable isotope labeling with aminoacids in cell culture (SILAC)

2016 ◽  
Vol 133 ◽  
pp. 100-112 ◽  
Author(s):  
Victor Llombart ◽  
Teresa García-Berrocoso ◽  
Joan Josep Bech-Serra ◽  
Alba Simats ◽  
Alejandro Bustamante ◽  
...  
Keyword(s):  
Cell Culture ◽  
Endothelial Cells ◽  
Stable Isotope ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
In Vitro Model ◽  
Isotope Labeling ◽  
Vitro Model

Development of an in vitro model of calcified cerebral emboli in acute ischemic stroke for mechanical thrombectomy evaluation

2020 ◽  
Vol 12 (10) ◽  
pp. 1002-1007
Author(s):  
Sarah Johnson ◽  
Ray McCarthy ◽  
Brian Fahy ◽  
Oana Madalina Mereuta ◽  
Seán Fitzgerald ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
In Vitro Model ◽  
Mechanical Thrombectomy ◽  
Ex Vivo ◽  
Guide Catheter ◽  
Vitro Model ◽  
Calcified Tissues

​BackgroundCalcified cerebral emboli (CCEs) are a rare cause of acute ischemic stroke (AIS) and are frequently associated with poor outcomes. The presence of dense calcified material enables reliable identification of CCEs using non-contrast CT. However, recanalization rates with the available mechanical thrombectomy (MT) devices remain low.ObjectiveTo recreate a large vessel occlusion involving a CCE using an in vitro silicone model of the intracranial vessels and to demonstrate the feasability of this model to test different endovascular strategies to recanalize an occlusion of the M1 segment of the middle cerebral artery (MCA).​MethodsAn in vitro model was developed to evaluate different endovascular treatment approaches using contemporary devices in the M1 segment of the MCA. The in vitro model consisted of a CCE analog placed in a silicone neurovascular model. Development of an appropriate CCE analog was based on characterization of human calcified tissues that represent likely sources of CCEs. Feasibility of the model was demonstrated in a small number of MT devices using four common procedural techniques.​ResultsCCE analogs were developed with similar mechanical behavior to that of ex vivo calcified material. The in vitro model was evaluated with various MT techniques and devices to show feasibility of the model. In this limited evaluation, the most successful retrieval approach was performed with a stent retriever combined with local aspiration through a distal access catheter, and importantly, with flow arrest and dual aspiration using a balloon guide catheter.​ConclusionCharacterization of calcified tissues, which are likely sources of CCEs, has shown that CCEs are considerably stiffer than thrombus. This highlights the need for a different in vitro AIS model for CCEs than those used for thromboemboli. Consequentially, an in vitro AIS model representative of a CCE occlusion in the M1 segment of the MCA has been developed.

Morphological characterization of the adherence and invasion ofStreptococcus agalactiaeto the intestinal mucosa of tilapiaOreochromissp.: An in vitro model

2019 ◽  
Vol 42 (9) ◽  
pp. 1223-1231 ◽  
Author(s):  
Gersson Vásquez‐Machado ◽  
Paola Barato‐Gómez ◽  
Carlos Iregui‐Castro
Keyword(s):  
Intestinal Mucosa ◽  
In Vitro Model ◽  
Morphological Characterization ◽  
Vitro Model
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