Biomimetic organic-inorganic hybrid hydrogel electrospinning periosteum for accelerating bone regeneration

2020 ◽  
Vol 110 ◽  
pp. 110670 ◽  
Author(s):  
Wenjuan Liu ◽  
Wei Bi ◽  
Yang Sun ◽  
Lei Wang ◽  
Xiaohua Yu ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation

2020 ◽  
Vol 6 (6) ◽  
pp. 3270-3274 ◽  
Author(s):  
Liping Huang ◽  
Jianhua Zhang ◽  
Junfei Hu ◽  
Tianbao Zhao ◽  
Zhipeng Gu
Keyword(s):  
Bone Regeneration ◽  
Fish Bone ◽  
Hybrid Hydrogel

Ultraviolet-Crosslinkable and Injectable Chitosan/Hydroxyapatite Hybrid Hydrogel for Critical Size Calvarial Defect Repair In Vivo

2015 ◽  
Vol 6 (4) ◽  
Author(s):  
Baoqiang Li ◽  
Lei Wang ◽  
Yu Hao ◽  
Daqing Wei ◽  
Ying Li ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Critical Size ◽  
Rabbit Model ◽  
Single Step ◽  
Calvarial Defect ◽  
Defect Model ◽  
Calvarial Bone ◽  
Hybrid Hydrogel ◽  
Defect Site

To promote bone regeneration in vivo using critical-size calvarial defect model, hybrid hydrogel was prepared by mixing chitosan with hydroxyapatite (HA) and ultraviolet (UV) irradiation in situ. The hydrosoluble, UV-crosslinkable and injectable N-methacryloyl chitosan (N-MAC) was synthesized via single-step N-acylation reaction. The chemical structure was confirmed by 1H-NMR and FTIR spectroscopy. N-MAC hydrogel presented a microporous structure with pore sizes ranging from 10 to 60 μm. Approximately 80% cell viability of N-MAC hydrogel against encapsulated 3T3 cell indicated that N-MAC is an emerging candidate for mimicking native extracellular matrix (ECM). N-MAC hydrogel hybridized with HA was used to accelerate regeneration of calvarial bone using rabbit model. The effects of hybrid hydrogels to promote bone regeneration were evaluated using critical size calvarial bone defect model. The healing effects of injectable hydrogels with/without HA for bone regeneration were investigated by analyzing X-ray image after 4 or 6 weeks. The results showed that the regenerated new bone for N-MAC 100 was significantly greater than N-MAC without HA and untreated controls. The higher HA content in N-MAC/HA hybrid hydrogel benefited the acceleration of bone regeneration. About 50% closure of defect site after 6 weeks postimplantation demonstrated potent osteoinductivity of N-MAC 100 UV-crosslinkable and injectable N-MAC/HA hybrid hydrogel would allow serving as a promising biomaterial for bone regeneration using the critical-size calvarial defect.

Synthesis and Characterization of a New Organic-Inorganic Hybrid Hydrogel by Using SiO2 Nanoparticles as an Initiator

2018 ◽  
Vol 65 (2) ◽  
pp. 225-230 ◽  
Author(s):  
Xinfang Wei ◽  
Haiwang Wang ◽  
Jiali Bian ◽  
Hongyu Xu ◽  
Jiajie Wu ◽  
...  
Keyword(s):  
Sio2 Nanoparticles ◽  
Synthesis And Characterization ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

scholarly journals A muscle mimetic polyelectrolyte–nanoclay organic–inorganic hybrid hydrogel: its self-healing, shape-memory and actuation properties

2019 ◽  
Vol 7 (9) ◽  
pp. 1475-1493 ◽  
Author(s):  
Sovan Lal Banerjee ◽  
Thomas Swift ◽  
Richard Hoskins ◽  
Stephen Rimmer ◽  
Nikhil K. Singha
Keyword(s):  
Hydrogen Bonding ◽  
Shape Memory ◽  
Self Healing ◽  
Nanocomposite Hydrogel ◽  
Hybrid Nanocomposite ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

In this investigation, we report a non-covalent (ionic interlocking and hydrogen bonding) strategy of self-healing in a covalently crosslinked organic–inorganic hybrid nanocomposite hydrogel, with specific emphasis on tuning its properties fitting into a muscle mimetic material.

Fabrication and Properties of Thermosensitive Organic/Inorganic Hybrid Hydrogel Thin Films

Langmuir ◽  
2008 ◽  
Vol 24 (10) ◽  
pp. 5543-5551 ◽  
Author(s):  
Zheng Cao ◽  
Binyang Du ◽  
Tianyou Chen ◽  
Haotian Li ◽  
Junting Xu ◽  
...  
Keyword(s):  
Thin Films ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

scholarly journals Preparation and Characterization of Organic-Inorganic Hybrid Hydrogel Electrolyte Using Alkaline Solution

Polymers ◽  
2011 ◽  
Vol 3 (4) ◽  
pp. 1600-1606 ◽  
Author(s):  
Masanobu Chiku ◽  
Shoji Tomita ◽  
Eiji Higuchi ◽  
Hiroshi Inoue
Keyword(s):  
Alkaline Solution ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

Preparation of Microporous, Thermosensitive Organic-Inorganic Hybrid Hydrogel with Simultaneous Control of Phase Separation and Sol-Gel Process

2008 ◽  
Vol 54 ◽  
pp. 109-113
Author(s):  
Iku Sakuhara ◽  
Eri Umebayashi ◽  
Kazuho Suguro ◽  
Wakaaki Murai ◽  
Tomohiro Morohoshi ◽  
...  
Keyword(s):  
Phase Separation ◽  
Sol Gel ◽  
Polymer Network ◽  
Radical Reaction ◽  
Diffusion Path ◽  
Vinyl Monomer ◽  
Solution Temperature ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid ◽  
Simultaneous Control

To control the microstructure and the responsive rates of hydrogels, a temperature-induced phase separation (TIPS) method applied to an organic-inorganic hybrid hydrogel. A copolymer between thermosensitive poly(N-isopropylacrylamide), polyNIPA, and a vinyl monomer possessing a trimethoxysilyl group was synthesized by radical reaction. Its cross-linking could be carried out by hydrolytic polycondensation of trimethoxysilyl groups. During both reactions, the pre-gel solution was separated into two phases by heating above a lower critical solution temperature of the elongating polyNIPA copolymer. The responsive rates of the microporous gel could be controlled by characteristic diffusion path length as the thickness of micropore wall, instead of the macroscopic sample size. Therefore, the shrinking rates of the hydrogel could be successfully maximized by fixing the phase-separated, microporous polymer network. Besides the interconnectivity of generated pores, the thermally triggered shrinking kinetics was investigated.

scholarly journals A Thermogelling Organic-Inorganic Hybrid Hydrogel with Excellent Printability, Shape Fidelity and Cytocompatibility for 3D Bioprinting

2021 ◽  
Author(s):  
Chen Hu ◽  
Taufiq Ahmad ◽  
Malik Salman Haider ◽  
Lukas Hahn ◽  
Philipp Stahlhut ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Shear Thinning ◽  
3D Bioprinting ◽  
Hybrid Hydrogel ◽  
Inorganic Hybrid

In this study, an advanced hybrid ink was developed, based on a thermogelling block copolymer, alginate and clay. The reversible thermogelling and shear thinning properties polymer acts at the same time as a fugitive material on the macromolecular level and facilitates the cell-laden extrusion based bioprinting. <br>

Sign in / Sign up

Export Citation Format

Share Document