scholarly journals First report of cryptococcosis due to Cryptococcus gattii sensu stricto VGI in an Ivorian HIV negative patient

2021 ◽  
Vol 31 (2) ◽  
pp. 101113
Author(s):  
V. Bellet ◽  
F.K. Kassi ◽  
D. Krasteva ◽  
F. Roger ◽  
P. Drakulovski ◽  
...  
Keyword(s):  
Sensu Stricto ◽  
Cryptococcus Gattii ◽  
Negative Patient ◽  
First Report ◽  
Hiv Negative

scholarly journals Cryptococcus gattii meningoencephalitis in an HIV-negative patient from the Peruvian Andes

2010 ◽  
Vol 43 (4) ◽  
pp. 469-471 ◽  
Author(s):  
Ericson L. Gutierrez ◽  
Willi Valqui ◽  
Luis Vilchez ◽  
Lourdes Evangelista ◽  
Sarita Crispin ◽  
...  
Keyword(s):  
Infectious Agent ◽  
Cryptococcus Gattii ◽  
Oral Fluconazole ◽  
Negative Patient ◽  
Peruvian Andes ◽  
The Andes ◽  
History Of ◽  
Cerebrospinal Fluid Culture ◽  
Hiv Negative ◽  
Fluid Culture

We report a case of an immunocompetent Peruvian patient from the Andes with a one-month history of meningoencephalitis. Cryptococcus gattii was identified from a cerebrospinal fluid culture through assimilation of D-proline and D-tryptophan as the single nitrogen source. Initially, the patient received intravenous antifungal therapy with amphotericin B. The patient was discharged 29 days after hospitalization and continued with oral fluconazole treatment for ten weeks. During this period, the patient showed clinical improvement with slight right-side residual weakness. Through this case report, we confirm the existence of this microorganism as an infectious agent in Peru.

scholarly journals HIV-negative case of Talaromyces marneffei pulmonary infection with a TSC2 mutation

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110167
Author(s):  
Qian Shen ◽  
Lingyan Sheng ◽  
Jianying Zhou
Keyword(s):  
Pulmonary Infection ◽  
Pathogenic Fungus ◽  
Critical Role ◽  
Lavage Fluid ◽  
Tsc2 Gene ◽  
Current Case ◽  
Negative Patient ◽  
Talaromyces Marneffei ◽  
Negative Case ◽  
Hiv Negative

Talaromyces marneffei is a rare dimorphic pathogenic fungus that can induce severe infections in human immunodeficiency virus (HIV)-infected patients. However, such infections have also been reported in non-HIV hosts. This current case report describes a very rare case of a T. marneffei pulmonary infection in an HIV-negative patient with a mutation in the tuberous sclerosis complex subunit 2 ( TSC2) gene. A 24-year-old male patient presented with cough and expectoration for 6 months. Computed tomography showed multiple ground-glass opacities and cystic and cavitated lesions in both lungs. Next generation sequencing (NGS) of the bronchoalveolar lavage fluid was performed to confirm T. marneffei pulmonary infection. The results were further verified using bronchoscopy specimen cultures. This was an HIV-negative patient without a travel history to endemic zones and his blood exon sequencing results showed a mutation in the TSC2 gene. To date, he has recovered well with voriconazole therapy. In summary, patients with TSC2 mutations that induce bronchopulmonary dysplasia may be potential hosts for T. marneffei. Early and timely diagnosis is important for improving prognosis. NGS plays a critical role in the diagnosis of T. marneffei pulmonary infection.

scholarly journals Cryptococcal granulomas in an immunocompromised HIV-negative patient

2008 ◽  
Vol 51 (4) ◽  
pp. 553 ◽  
Author(s):  
Juhi Taneja ◽  
Aradhana Bhargava ◽  
Poonam Loomba ◽  
Vinita Dogra ◽  
Archana Thakur ◽  
...  
Keyword(s):  
Negative Patient ◽  
Hiv Negative
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