Targeting of folate-conjugated liposomes with co-entrapped drugs to prostate cancer cells via prostate-specific membrane antigen (PSMA)

2018 ◽  
Vol 14 (4) ◽  
pp. 1407-1416 ◽  
Author(s):  
Yogita Patil ◽  
Hilary Shmeeda ◽  
Yasmine Amitay ◽  
Patricia Ohana ◽  
Saran Kumar ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Specific Membrane

1α,25-Dihydroxyvitamin D3 down-regulates expression of prostate specific membrane antigen in prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (7) ◽  
pp. 773-783 ◽  
Author(s):  
Rita E. Serda ◽  
Marco Bisoffi ◽  
Todd A. Thompson ◽  
Ming Ji ◽  
John L. Omdahl ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Dihydroxyvitamin D3 ◽  
Specific Membrane

scholarly journals Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands

2022 ◽  
Author(s):  
Lei Wang ◽  
Lei Tang ◽  
Yingjie Liu ◽  
Hao Wu ◽  
Ziang Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Oxygen Delivery ◽  
Modular Design ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Tethered Ligands ◽  
Specific Membrane

A PSMA targeting ligand is functionalized with endoperoxides which thermally release singlet oxygen. The results show that this modular design results in significantly more cell death in PSMA-expressing prostate cancer cells.

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