Abstract A136: Lysosome‐targeted photodynamic therapy for prostate cancer cells with a pyropheophorbide‐α conjugated inhibitor of prostate‐specific membrane antigen

2009 ◽  
Author(s):  
Tiancheng Liu ◽  
Lisa Y. Wu ◽  
Clifford E. Berkman
Keyword(s):  
Prostate Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Targeted Photodynamic Therapy ◽  
Specific Membrane

1α,25-Dihydroxyvitamin D3 down-regulates expression of prostate specific membrane antigen in prostate cancer cells

The Prostate ◽  
2008 ◽  
Vol 68 (7) ◽  
pp. 773-783 ◽  
Author(s):  
Rita E. Serda ◽  
Marco Bisoffi ◽  
Todd A. Thompson ◽  
Ming Ji ◽  
John L. Omdahl ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Dihydroxyvitamin D3 ◽  
Specific Membrane

scholarly journals Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands

2022 ◽  
Author(s):  
Lei Wang ◽  
Lei Tang ◽  
Yingjie Liu ◽  
Hao Wu ◽  
Ziang Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Oxygen Delivery ◽  
Modular Design ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Tethered Ligands ◽  
Specific Membrane

A PSMA targeting ligand is functionalized with endoperoxides which thermally release singlet oxygen. The results show that this modular design results in significantly more cell death in PSMA-expressing prostate cancer cells.

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