Human apolipoprotein E isoforms are differentially sialylated and the sialic acid moiety in ApoE2 attenuates ApoE2-Aβ interaction and Aβ fibrillation

AbstractIn order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.

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Microstructure of the sialic acid moiety of N-glycolylneuraminyllactosylceramide and the elucidation of Hanganutziu and Deicher (HD) antigenicity

Immunology Letters ◽

10.1016/0165-2478(86)90100-8 ◽

1986 ◽

Vol 12 (2-3) ◽

pp. 165-169 ◽

Cited By ~ 4

Author(s):

Joseph C. Mukuria ◽

Masaharu Naiki ◽

Shiro Kato

Keyword(s):

Sialic Acid ◽

Acid Moiety ◽

Sialic Acid Moiety

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An Oligomannuronic Acid–Sialic Acid Conjugate Capable of Inhibiting Aβ42 Aggregation and Alleviating the Inflammatory Response of BV-2 Microglia

International Journal of Molecular Sciences ◽

10.3390/ijms222212338 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12338

Author(s):

Jianrong Wu ◽

Miaosen Wu ◽

Hongtao Zhang ◽

Xiaobei Zhan ◽

Nian Wu

Keyword(s):

Sialic Acid ◽

Inflammatory Response ◽

Structure Formation ◽

Acid Moiety ◽

Binding Effect ◽

Tnf Α ◽

The Future ◽

Acid Conjugate ◽

Sialic Acid Moiety ◽

Proinflammatory Factors

Oligomannuronic acid (MOS) from seaweed has antioxidant and anti-inflammatory activities. In this study, MOS was activated at the terminal to obtain three different graft complexes modified with sialic acid moiety (MOS-Sia). The results show that MOS-Sia addition can reduce the β-structure formation of Aβ42, and the binding effect of MOS-Sia3 is more obvious. MOS-Sia conjugates also have a better complexing effect with Ca2+ while reducing the formation of Aβ42 oligomers in solutions. MOS-Sia3 (25–50 μg/mL) can effectively inhibit the activation state of BV-2 cells stimulated by Aβ42, whereas a higher dose of MOS-Sia3 (>50 μg/mL) can inhibit the proliferation of BV-2 cells to a certain extent. A lower dose of MOS-Sia3 can also inhibit the expression of IL-1β, IL-6, TNF-α, and other proinflammatory factors in BV-2 cells induced by Aβ42 activation. In the future, the MOS-Sia3 conjugate can be used to treat Alzheimer’s disease.

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Intramolecular Lactones of Sialic Acids

International Journal of Molecular Sciences ◽

10.3390/ijms21218098 ◽

2020 ◽

Vol 21 (21) ◽

pp. 8098

Author(s):

Paola Rota ◽

Paolo La Rocca ◽

Pietro Allevi ◽

Carlo Pappone ◽

Luigi Anastasia

Keyword(s):

Sialic Acid ◽

Biological Samples ◽

Chemical Biology ◽

Research Area ◽

Sialic Acids ◽

Acid Moiety ◽

Pathological Conditions ◽

Depth Analysis ◽

Correct Determination ◽

Sialic Acid Moiety

The so-called “sialo-chemical-biology” has become an attractive research area, as an increasing number of natural products containing a sialic acid moiety have been shown to play important roles in biological, pathological, and immunological processes. The intramolecular lactones of sialic acids are a subclass from this crucial family that could have central functions in the discrimination of physiological and pathological conditions. In this review, we report an in-depth analysis of the synthetic achievements in the preparation of the intramolecular lactones of sialic acids (1,4-, 1,7- and γ-lactones), in their free and/or protected form. In particular, recent advances in the synthesis of the 1,7-lactones have allowed the preparation of key sialic acid derivatives. These compounds could be used as authentic reference standards for their correct determination in biological samples, thus overcoming some of the limitations of the previous analytical procedures.

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