Sialic acid moiety of apolipoprotein E and its impact on the formation of lipoprotein particles in human cerebrospinal fluid

AbstractIn order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.

Download Full-text

P1-174: Quantitative mass spectrometry (SRM/MRM) for amyloid peptides, tau protein and apolipoprotein E in human cerebrospinal fluid for Alzheimer's disease diagnosis

Alzheimer s & Dementia ◽

10.1016/j.jalz.2013.05.397 ◽

2013 ◽

Vol 9 ◽

pp. P212-P212 ◽

Cited By ~ 3

Author(s):

Sylvain Lehmann ◽

Nicolas Barthelemy ◽

Jerome Vialaret ◽

Susanna Schraen-Maschke ◽

Laurent Tiers ◽

...

Keyword(s):

Mass Spectrometry ◽

Alzheimer’S Disease ◽

Cerebrospinal Fluid ◽

Apolipoprotein E ◽

Tau Protein ◽

Disease Diagnosis ◽

Quantitative Mass Spectrometry ◽

Amyloid Peptides ◽

Human Cerebrospinal Fluid ◽

Alzheimer’S Disease Diagnosis

Download Full-text

Microstructure of the sialic acid moiety of N-glycolylneuraminyllactosylceramide and the elucidation of Hanganutziu and Deicher (HD) antigenicity

Immunology Letters ◽

10.1016/0165-2478(86)90100-8 ◽

1986 ◽

Vol 12 (2-3) ◽

pp. 165-169 ◽

Cited By ~ 4

Author(s):

Joseph C. Mukuria ◽

Masaharu Naiki ◽

Shiro Kato

Keyword(s):

Sialic Acid ◽

Acid Moiety ◽

Sialic Acid Moiety

Download Full-text

An Oligomannuronic Acid–Sialic Acid Conjugate Capable of Inhibiting Aβ42 Aggregation and Alleviating the Inflammatory Response of BV-2 Microglia

International Journal of Molecular Sciences ◽

10.3390/ijms222212338 ◽

2021 ◽

Vol 22 (22) ◽

pp. 12338

Author(s):

Jianrong Wu ◽

Miaosen Wu ◽

Hongtao Zhang ◽

Xiaobei Zhan ◽

Nian Wu

Keyword(s):

Sialic Acid ◽

Inflammatory Response ◽

Structure Formation ◽

Acid Moiety ◽

Binding Effect ◽

Tnf Α ◽

The Future ◽

Acid Conjugate ◽

Sialic Acid Moiety ◽

Proinflammatory Factors

Oligomannuronic acid (MOS) from seaweed has antioxidant and anti-inflammatory activities. In this study, MOS was activated at the terminal to obtain three different graft complexes modified with sialic acid moiety (MOS-Sia). The results show that MOS-Sia addition can reduce the β-structure formation of Aβ42, and the binding effect of MOS-Sia3 is more obvious. MOS-Sia conjugates also have a better complexing effect with Ca2+ while reducing the formation of Aβ42 oligomers in solutions. MOS-Sia3 (25–50 μg/mL) can effectively inhibit the activation state of BV-2 cells stimulated by Aβ42, whereas a higher dose of MOS-Sia3 (>50 μg/mL) can inhibit the proliferation of BV-2 cells to a certain extent. A lower dose of MOS-Sia3 can also inhibit the expression of IL-1β, IL-6, TNF-α, and other proinflammatory factors in BV-2 cells induced by Aβ42 activation. In the future, the MOS-Sia3 conjugate can be used to treat Alzheimer’s disease.

Download Full-text