Treatment with nerve growth factor decreases expression of divalent metal transporter 1 and transferrin receptor in PC12 cells

2005 ◽  
Vol 47 (7) ◽  
pp. 514-517 ◽  
Author(s):  
Jun Wang ◽  
Zhong-ming Qian ◽  
Hong Jiang ◽  
Junxia Xie ◽  
Ya Ke
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Transferrin Receptor ◽  
Divalent Metal ◽  
Divalent Metal Transporter 1 ◽  
Nerve Growth ◽  
Divalent Metal Transporter ◽  
Metal Transporter

Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats

2000 ◽  
Vol 278 (6) ◽  
pp. G930-G936 ◽  
Author(s):  
Phillip S. Oates ◽  
Carla Thomas ◽  
Elizabeth Freitas ◽  
Matthew J. Callow ◽  
Evan H. Morgan
Keyword(s):  
Gene Expression ◽  
Transferrin Receptor ◽  
Wistar Rats ◽  
Iron Concentration ◽  
Divalent Metal ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
Metal Transporter ◽  
Transferrin Cycle ◽  
Crypt Cells

Regulation of iron absorption is thought to be mediated by the amount of iron taken up by duodenal crypt cells via the transferrin receptor (TfR)-transferrin cycle and the activity of the divalent metal transporter (DMT1), although DMT1 cannot be detected morphologically in crypt cells. We investigated the uptake of transferrin-bound iron by duodenal enterocytes in Wistar rats fed different levels of iron and Belgrade (b/b) rats in which iron uptake by the transferrin cycle is defective because of a mutation in DMT1. We showed that DMT1 in our colony of b/b rats contains the G185R mutation, which in enterocytes results in reduced cellular iron content and increased DMT1 gene expression similar to levels in iron deficiency of normal rats. In all groups the uptake of transferrin-bound iron by crypt cells was directly proportional to plasma iron concentration, being highest in iron-loaded Wistar rats and b/b rats. We conclude that the uptake of transferrin-bound iron by developing enterocytes is largely independent of DMT1.

Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) expression in duodenal biopsies from celiac patients

2001 ◽  
Vol 120 (5) ◽  
pp. A681
Author(s):  
Donatella Barisani ◽  
Antonina Parafioriti ◽  
Elisabetta Armiraglio ◽  
Dario Conte ◽  
Robert O. Koch ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Divalent Metal ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
Metal Transporter ◽  
Duodenal Biopsies

Divalent metal transporter 1 (DMT1) and transferrin receptor (TfR) expression in duodenal biopsies from celiac patients

2001 ◽  
Vol 120 (5) ◽  
pp. A681-A681
Author(s):  
D BARISANI ◽  
A PARAFIORITI ◽  
E ARMIRAGLIO ◽  
D CONTE ◽  
R KOCH ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Divalent Metal ◽  
Divalent Metal Transporter 1 ◽  
Divalent Metal Transporter ◽  
Metal Transporter ◽  
Duodenal Biopsies

Hypoxia induces changes in expression of isoforms of the divalent metal transporter (DMT1) in rat pheochromocytoma (PC12) cells

2005 ◽  
Vol 69 (11) ◽  
pp. 1647-1655 ◽  
Author(s):  
Agnieszka Lis ◽  
Prasad N. Paradkar ◽  
Steve Singleton ◽  
Hung-Chieh Kuo ◽  
Michael D. Garrick ◽  
...  
Keyword(s):  
Pc12 Cells ◽  
Divalent Metal ◽  
Divalent Metal Transporter ◽  
Metal Transporter ◽  
Pheochromocytoma Pc12 ◽  
Pheochromocytoma Pc12 Cells

scholarly journals Nerve growth factor-induced decrease in the cell-free phosphorylation of a soluble protein in PC12 cells.

1983 ◽  
Vol 258 (10) ◽  
pp. 6549-6555 ◽  
Author(s):  
D End ◽  
N Tolson ◽  
S Hashimoto ◽  
G Guroff
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pc12 Cells ◽  
Soluble Protein ◽  
Nerve Growth
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