Blood-based biomarkers of agitation in Alzheimer's disease: Advances and future prospects

2022 ◽  
Vol 152 ◽  
pp. 105250
Author(s):  
Shankar Tumati ◽  
Nathan Herrmann ◽  
Giovanni Marotta ◽  
Abby Li ◽  
Krista L. Lanctôt
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Future Prospects

Repurposing Antihypertensive Drugs for the Management of Alzheimer’s Disease

2020 ◽  
Vol 27 ◽  
Author(s):  
Keng Yoon Yeong ◽  
Christine Law
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Risk Factor ◽  
Literature Review ◽  
Neurodegenerative Disorder ◽  
Antihypertensive Drugs ◽  
Future Prospects ◽  
Short Term

Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review.

Search for biomarkers of Alzheimer‘s disease: Recent insights, current challenges and future prospects

2019 ◽  
Vol 72 ◽  
pp. 39-51 ◽  
Author(s):  
Kateřina Hrubešová ◽  
Markéta Fousková ◽  
Lucie Habartová ◽  
Zdeněk Fišar ◽  
Roman Jirák ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Future Prospects

Future prospects and challenges for Alzheimer's disease drug development in the era of the NIA-AA Research Framework

2018 ◽  
Vol 14 (4) ◽  
pp. 532-534 ◽  
Author(s):  
Ara S. Khachaturian ◽  
Kathleen M. Hayden ◽  
Michelle M. Mielke ◽  
Yi Tang ◽  
Michael W. Lutz ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Drug Development ◽  
Future Prospects ◽  
Research Framework

scholarly journals Current progress, challenges and future prospects of diagnostic and therapeutic interventions in Alzheimer's disease

RSC Advances ◽  
2018 ◽  
Vol 8 (42) ◽  
pp. 23780-23804 ◽  
Author(s):  
K. Rajasekhar ◽  
Thimmaiah Govindaraju
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Interventions ◽  
Future Prospects

The diverse pathological mechanisms and their implications for the development of effective diagnostic and therapeutic interventions in Alzheimer's disease are presented with current progress, challenges and future prospects.

scholarly journals The fluid biomarkers of Alzheimer’s disease

2021 ◽  
Vol 7 (1) ◽  
pp. 1-16
Author(s):  
Qinyu Peng ◽  
Zhentao Zhang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Early Diagnosis ◽  
Neurodegenerative Disorder ◽  
Future Prospects ◽  
Research Directions ◽  
Disease Modifying Therapies ◽  
Highly Sensitive ◽  
Disease Modifying ◽  
Common Neurodegenerative Disorder

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. However, it still has no available disease‐modifying therapies. Its pathology cascade begins decades before symptomatic presentation. For these reasons, highly sensitive and highly specific fluid biomarkers should be developed for the early diagnosis of AD. In this study, the well‐established and emerging fluid biomarkers of AD are summarized, and recent advances on their role in early diagnosis and progression monitoring as well as their correlations with AD pathology are highlighted. Future prospects and related research directions are also discussed.

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