Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset

2003 ◽  
Vol 353 (1) ◽  
pp. 75-77 ◽  
Author(s):  
Chen-Jee Hong ◽  
Hsiu-Chih Liu ◽  
Tsung-Yun Liu ◽  
Ching-Hua Lin ◽  
Chih-Ya Cheng ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Age Of Onset ◽  
Brain Derived Neurotrophic Factor

scholarly journals Serum level of brain-derived neurotrophic factor in Parkinson's disease: a meta-analysis

2019 ◽  
Vol 88 ◽  
pp. 168-174 ◽  
Author(s):  
Lina Jiang ◽  
Hainan Zhang ◽  
Chunyu Wang ◽  
Fengyu Ming ◽  
Xiaoliu Shi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Serum Level ◽  
Neurotrophic Factor ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor

scholarly journals Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson's disease and does not lead to a sustainable increase of brain‐derived neurotrophic factor

2018 ◽  
Vol 147 (5) ◽  
pp. 678-691 ◽  
Author(s):  
Daniel Komnig ◽  
Toruntay Cem Dagli ◽  
Pardes Habib ◽  
Thomas Zeyen ◽  
Jörg B. Schulz ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson’s disease

2010 ◽  
Vol 122 (1) ◽  
pp. 41-45 ◽  
Author(s):  
L. Gao ◽  
F. J. Díaz-Corrales ◽  
F. Carrillo ◽  
J. Díaz-Martín ◽  
M. T. Caceres-Redondo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Features ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Plasma Exosomal Brain-Derived Neurotrophic Factor Correlated with the Postural Instability and Gait Disturbance–Related Motor Symptoms in Patients with Parkinson’s Disease

Diagnostics ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 684
Author(s):  
Chen Chih Chung ◽  
Pai Hao Huang ◽  
Lung Chan ◽  
Jia-Hung Chen ◽  
Li-Nien Chien ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Rating Scale ◽  
Brain Derived Neurotrophic Factor ◽  
Postural Instability ◽  
Gait Disturbance ◽  
Enzyme Linked Immunosorbent Assay ◽  
Motor Symptoms ◽  
Bdnf Level

Brain-derived neurotrophic factor (BDNF) is an essential neurotrophin, responsible for neuronal development, function, and survival. Assessments of peripheral blood BDNF in patients with Parkinson’s disease (PD) previously yielded inconsistent results. Plasma exosomes can carry BDNF, so this study investigated the role of plasma exosomal BDNF level as a biomarker of PD. A total of 114 patients with mild to moderate PD and 42 non-PD controls were recruited, and their clinical presentations were evaluated. Plasma exosomes were isolated with exoEasy Maxi Kits, and enzyme-linked immunosorbent assay was used to assess plasma exosomal BDNF levels. Statistical analysis was performed using SPSS version 19.0, and findings were considered significant at p < 0.05. The analysis revealed no significant differences in plasma exosomal BDNF levels between patients with PD and controls. Patients with PD with low plasma exosomal BDNF levels (in the lowest quartile) exhibited a significant association with daily activity dysfunction but not with cognition/mood or overall motor symptoms as assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS). Investigation of UPDRS part III subitems revealed that low plasma exosomal BDNF level was significantly associated with increased motor severity of postural instability and gait disturbance (PIGD)-associated symptoms (rising from a chair, gait, and postural stability) after adjustment for age and sex. In conclusion, although plasma exosomal BDNF level could not distinguish patients with PD from controls, the association with PIGD symptoms in patients with PD may indicate its potential role as a biomarker. Follow-up studies should investigate the association between plasma exosomal BDNF levels and changes in clinical symptoms.

Serum levels of brain-derived neurotrophic factor correlate with motor impairment in Parkinson’s disease

2009 ◽  
Vol 257 (4) ◽  
pp. 540-545 ◽  
Author(s):  
Paula Scalzo ◽  
Arthur Kümmer ◽  
Thales Lage Bretas ◽  
Francisco Cardoso ◽  
Antônio Lúcio Teixeira
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neurotrophic Factor ◽  
Motor Impairment ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor
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