Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model

2010 ◽  
Vol 472 (3) ◽  
pp. 215-219 ◽  
Author(s):  
Jin Soo Oh ◽  
Yoon Ha ◽  
Sung Su An ◽  
Momin Khan ◽  
William A. Pennant ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals A Neonatal Mouse Spinal Cord Injury Model for Assessing Post-Injury Adaptive Plasticity and Human Stem Cell Integration

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71701 ◽  
Author(s):  
Jean-Luc Boulland ◽  
François M. Lambert ◽  
Mark Züchner ◽  
Susanne Ström ◽  
Joel C. Glover
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Adaptive Plasticity ◽  
Human Stem Cell ◽  
Post Injury ◽  
Mouse Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals Influence of Different ECM-Like Hydrogels on Neurite Outgrowth Induced by Adipose Tissue-Derived Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
E. Oliveira ◽  
R. C. Assunção-Silva ◽  
O. Ziv-Polat ◽  
E. D. Gomes ◽  
F. G. Teixeira ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Growth Factors ◽  
Axonal Outgrowth ◽  
Mrna Levels ◽  
Cord Injury

Mesenchymal stem cells (MSCs) have been proposed for spinal cord injury (SCI) applications due to their capacity to secrete growth factors and vesicles—secretome—that impacts important phenomena in SCI regeneration. To improve MSC survival into SCI sites, hydrogels have been used as transplantation vehicles. Herein, we hypothesized if different hydrogels could interact differently with adipose tissue-derived MSCs (ASCs). The efficacy of three natural hydrogels, gellan gum (functionalized with a fibronectin peptide), collagen, and a hydrogel rich in laminin epitopes (NVR-gel) in promoting neuritogenesis (alone and cocultured with ASCs), was evaluated in the present study. Their impact on ASC survival, metabolic activity, and gene expression was also evaluated. Our results indicated that all hydrogels supported ASC survival and viability, being this more evident for the functionalized GG hydrogels. Moreover, the presence of different ECM-derived biological cues within the hydrogels appears to differently affect the mRNA levels of growth factors involved in neuronal survival, differentiation, and axonal outgrowth. All the hydrogel-based systems supported axonal growth mediated by ASCs, but this effect was more robust in functionalized GG. The data herein presented highlights the importance of biological cues within hydrogel-based biomaterials as possible modulators of ASC secretome and its effects for SCI applications.

The combined application of human adipose derived stem cells and Chondroitinase ABC in treatment of a spinal cord injury model

Neuropeptides ◽  
2017 ◽  
Vol 61 ◽  
pp. 39-47 ◽  
Author(s):  
Arash Sarveazad ◽  
Asrin Babahajian ◽  
Mehrdad Bakhtiari ◽  
Mansoureh Soleimani ◽  
Babak Behnam ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Adipose Derived Stem Cells ◽  
Chondroitinase Abc ◽  
Combined Application ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

scholarly journals Characterization of epidermal neural crest stem cell (EPI‐NCSC) behavior in a spinal cord injury model

2006 ◽  
Vol 20 (4) ◽  
Author(s):  
Maya Sieber‐Blum ◽  
Lisa Schnell ◽  
Milos Grim ◽  
Martin E Schwab
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Stem Cell ◽  
Neural Crest ◽  
Neural Crest Stem Cell ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

Implantation of polymer scaffolds seeded with neural stem cells in a canine spinal cord injury model

Cytotherapy ◽  
2010 ◽  
Vol 12 (6) ◽  
pp. 841-845 ◽  
Author(s):  
Byung Gon Kim ◽  
Young Mi Kang ◽  
Ji Hoon Phi ◽  
Yoon-Ha Kim ◽  
Dong Hoon Hwang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Polymer Scaffolds ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

202. Ischemic injury specific VEGF gene expression in the rat spinal cord injury model using hypoxia-inducible system

2005 ◽  
Vol 5 (4) ◽  
pp. S104
Author(s):  
Yoon Ha ◽  
Young Soo Kim ◽  
So Ra Park ◽  
Seung-Hwan Yoon ◽  
Hyun Seon Park ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Ischemic Injury ◽  
Vegf Gene ◽  
Rat Spinal Cord ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury
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