Glutamatergic projection from the nucleus incertus to the septohippocampal system

1. Properties of nucleus incertus (NIC) neurons projecting to the cerebellar flocculus were studied in alert cats by using chronic unit and eye movement recording and antidromic activation. Projection of these neurons onto the flocculus was verified with retrograde transport of horseradish peroxidase after injections in the flocculus. 2. Bipolar stimulation electrodes were implanted into the "middle" zone of each flocculus because this zone is known to be involved in the control of horizontal eye movements. The dorsomedial aspect of the pontine tegmentum was explored with microelectrodes during stimulation of both flocculi. The majority of neurons antidromically activated from the flocculus were found in the caudal part of the NIC. 3. Of the 69 neurons activated from the flocculus, 44 were classified as burst-tonic (BT) neurons; 34 discharged in relation with horizontal movements of the eye, 10 in relation with vertical movements. Of the 14 remaining neurons, 6 were not related to eye movements and 8 were classified as burst neurons. The BT neurons of the NIC displayed a great sensitivity to both horizontal eye position and horizontal eye velocity. 4. This study demonstrates the presence of a new group of horizontal eye movement related BT neurons situated in the NIC. The fact that they project to the horizontal floccular zone emphasizes the importance of the functional specialization of the different Purkinje cell zones.

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Effects of elevated levels of nerve growth factor on the septohippocampal system in transgenic mice

European Journal of Neuroscience ◽

10.1046/j.1460-9568.1998.00228.x ◽

1998 ◽

Vol 10 (7) ◽

pp. 2207-2216 ◽

Cited By ~ 8

Author(s):

Michael D. Kawaja ◽

Gregory S. Walsh ◽

P. Ronald Tovich ◽

Jean-Pierre Julien

Keyword(s):

Nerve Growth Factor ◽

Growth Factor ◽

Transgenic Mice ◽

Nerve Growth ◽

Septohippocampal System

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Developmental expression and serotonergic regulation of relaxin 3/INSL7 in the nucleus incertus of rat brain

Regulatory Peptides ◽

10.1016/j.regpep.2007.08.010 ◽

2008 ◽

Vol 145 (1-3) ◽

pp. 54-59 ◽

Cited By ~ 37

Author(s):

Yasumasa Miyamoto ◽

Yoshihisa Watanabe ◽

Masaki Tanaka

Keyword(s):

Rat Brain ◽

Developmental Expression ◽

Nucleus Incertus

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Evidence for a Specific Information Processing Deficit in Monkeys with Lesions of the Septohippocampal System

Cortex ◽

10.1016/s0010-9452(97)80012-3 ◽

1997 ◽

Vol 33 (1) ◽

pp. 167-176 ◽

Cited By ~ 15

Author(s):

R.M. Ridley ◽

H.F. Baker

Keyword(s):

Information Processing ◽

Specific Information ◽

Septohippocampal System ◽

Processing Deficit

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Studies of wet-dog shake behavior induced by septohippocampal stimulation in the rat

Canadian Journal of Physiology and Pharmacology ◽

10.1139/y83-187 ◽

1983 ◽

Vol 61 (11) ◽

pp. 1299-1304 ◽

Cited By ~ 18

Author(s):

G. Le Gal La Salle ◽

E. A. Cavalheiro ◽

S. Feldblum ◽

D. Maresova

Keyword(s):

Time Course ◽

Pharmacological Data ◽

Wet Dog Shakes ◽

Septohippocampal System ◽

Stimulation Of

Stimulation of the septum and the hippocampus were found to elicit a great number of "wet-dog" shakes (WDS). Their occurrence is strongly related to the evocation and to the time course of the afterdischarges elicited by the stimulation. Morphine, apomorphine, diazepam, and antiserotoninergic drugs greatly reduce the incidence of these WDS but do not alter the afterdischarge duration. Based on electroencephalographic and pharmacological data we propose that WDS induced by stimulation of the septohippocampal system may share some common mechanisms with many other models inducing WDS and offer a useful method to study further the neuroanatomical substrate of this behavior.

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