Gray matter volume and executive functioning correlate with time since injury following mild traumatic brain injury

2016 ◽  
Vol 612 ◽  
pp. 238-244 ◽  
Author(s):  
William D.S. Killgore ◽  
Prabhjyot Singh ◽  
Maia Kipman ◽  
Derek Pisner ◽  
Andrew Fridman ◽  
...  
2018 ◽  
Vol 32 (4) ◽  
pp. 484-494 ◽  
Author(s):  
Emily C. Grossner ◽  
Rachel A. Bernier ◽  
Einat K. Brenner ◽  
Kathy S. Chiou ◽  
Frank G. Hillary

2018 ◽  
Vol 9 ◽  
Author(s):  
Alexandra L. Clark ◽  
Victoria C. Merritt ◽  
Erin D. Bigler ◽  
Katherine J. Bangen ◽  
Madeleine Werhane ◽  
...  

2021 ◽  
Vol 36 (6) ◽  
pp. 1167-1167
Author(s):  
Jason Bailie ◽  
Paul Sargent ◽  
Sandi Chapman ◽  
Melissa Caswell ◽  
Juan Lopez ◽  
...  

Abstract Background Military personnel require a level of cognitive readiness that ensures they function safely and effectively in high-stress situations. Warfighters who experienced a mild traumatic brain injury (mTBI) often complain of persistent cognitive issues that may impact those abilities. This study presents preliminary data on the efficacy of a 4-week Strategic Memory Advanced Reasoning Training (SMART) for warfighter rehabilitation. SMART improves executive functioning in order to enhance overall cognitive abilities. Methods This is part of a randomized clinical trial (Validation of Cognitive Enhancement Therapy for mTBI). 22 Marines with prior mTBI and current cognitive complaints; 7 of whom completed SMART and were included in the analysis. Cognitive tests of interest included the Delis-Kaplan Executive Function System Color Word (CW) and Trail Making (TM). Results Improvements were observed on TM Number Sequencing (Pre: M = 9.71, SD = 2.06; Post: M = 11.86, SD = 1.35, p = 0.011, d = 1.37) and approached significance on Letter Sequencing (Pre: M = 10.29, SD = 1.81; Post: M = 12.57, SD = 1.13, p = 0.066, d = 1.26). Though non-significant, a large clinically-relevant effect size was found for Number-Letter Switching (Pre: M = 8.14, SD = 1.95; Post: M = 9.57, SD = 2.15, p = 0.106, d = 0.72). CW performance improved on Inhibition (Pre: M = 5.29, SD = 3.86; Post: M = 8.86, SD = 2.34, p = 0.034, d = 1.03) and Inhibition/Switching (Pre: M = 4.86, SD = 4.06; Post: M = 8.43, SD = 4.12, p = 0.015, d = 1.26). Conclusions The SMART program resulted in large improvements in the executive functioning of a small sample of warfighters with persistent cognitive complaints following a mTBI. The results support further examination of the efficacy of SMART for warfighter rehabilitation.


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