Altered gray matter structural covariance networks at both acute and chronic stages of mild traumatic brain injury

2020 ◽  
Author(s):  
Jie Song ◽  
Jie Li ◽  
Lixiang Chen ◽  
Xingqi Lu ◽  
Senning Zheng ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter ◽  
Structural Covariance

Gray Matter Abnormalities in Pediatric Mild Traumatic Brain Injury

2015 ◽  
Vol 32 (10) ◽  
pp. 723-730 ◽  
Author(s):  
Andrew R. Mayer ◽  
Faith M. Hanlon ◽  
Josef M. Ling
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter

Gray matter volume and executive functioning correlate with time since injury following mild traumatic brain injury

2016 ◽  
Vol 612 ◽  
pp. 238-244 ◽  
Author(s):  
William D.S. Killgore ◽  
Prabhjyot Singh ◽  
Maia Kipman ◽  
Derek Pisner ◽  
Andrew Fridman ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Executive Functioning ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Time Since Injury

scholarly journals A prospective study of gray matter abnormalities in mild traumatic brain injury

Neurology ◽  
2013 ◽  
Vol 81 (24) ◽  
pp. 2121-2127 ◽  
Author(s):  
J. M. Ling ◽  
S. Klimaj ◽  
T. Toulouse ◽  
A. R. Mayer
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Prospective Study ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter ◽  
A Prospective Study

scholarly journals Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Karthik Chary ◽  
Omar Narvaez ◽  
Raimo A. Salo ◽  
Isabel San Martín Molina ◽  
Jussi Tohka ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter ◽  
Myelinated Fiber ◽  
Fiber Density ◽  
Brain Areas ◽  
Tissue Changes ◽  
Primary Injury ◽  
The Brain

Our study investigates the potential of diffusion MRI (dMRI), including diffusion tensor imaging (DTI), fixel-based analysis (FBA) and neurite orientation dispersion and density imaging (NODDI), to detect microstructural tissue abnormalities in rats after mild traumatic brain injury (mTBI). The brains of sham-operated and mTBI rats 35 days after lateral fluid percussion injury were imaged ex vivo in a 11.7-T scanner. Voxel-based analyses of DTI-, fixel- and NODDI-based metrics detected extensive tissue changes in directly affected brain areas close to the primary injury, and more importantly, also in distal areas connected to primary injury and indirectly affected by the secondary injury mechanisms. Histology revealed ongoing axonal abnormalities and inflammation, 35 days after the injury, in the brain areas highlighted in the group analyses. Fractional anisotropy (FA), fiber density (FD) and fiber density and fiber bundle cross-section (FDC) showed similar pattern of significant areas throughout the brain; however, FA showed more significant voxels in gray matter areas, while FD and FDC in white matter areas, and orientation dispersion index (ODI) in areas most damage based on histology. Region-of-interest (ROI)-based analyses on dMRI maps and histology in selected brain regions revealed that the changes in MRI parameters could be attributed to both alterations in myelinated fiber bundles and increased cellularity. This study demonstrates that the combination of dMRI methods can provide a more complete insight into the microstructural alterations in white and gray matter after mTBI, which may aid diagnosis and prognosis following a mild brain injury.

scholarly journals Increased Gray Matter Diffusion Anisotropy in Patients with Persistent Post-Concussive Symptoms following Mild Traumatic Brain Injury

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66205 ◽  
Author(s):  
Sylvain Bouix ◽  
Ofer Pasternak ◽  
Yogesh Rathi ◽  
Paula E. Pelavin ◽  
Ross Zafonte ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Gray Matter ◽  
Diffusion Anisotropy

The Speech-Language Pathologists' Role in Mild Traumatic Brain Injury for Middle and High School–Age Children: Viewpoints on Guidelines From the Centers for Disease Control and Prevention

2019 ◽  
Vol 28 (3) ◽  
pp. 1363-1370 ◽  
Author(s):  
Jessica Brown ◽  
Katy O'Brien ◽  
Kelly Knollman-Porter ◽  
Tracey Wallace
Keyword(s):  
High School ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Disease Control ◽  
Mild Traumatic Brain Injury ◽  
School Age Children ◽  
School Age ◽  
Speech Language Pathologists ◽  
Control And Prevention ◽  
Centers For Disease Control

Purpose The Centers for Disease Control and Prevention (CDC) recently released guidelines for rehabilitation professionals regarding the care of children with mild traumatic brain injury (mTBI). Given that mTBI impacts millions of children each year and can be particularly detrimental to children in middle and high school age groups, access to universal recommendations for management of postinjury symptoms is ideal. Method This viewpoint article examines the CDC guidelines and applies these recommendations directly to speech-language pathology practices. In particular, education, assessment, treatment, team management, and ongoing monitoring are discussed. In addition, suggested timelines regarding implementation of services by speech-language pathologists (SLPs) are provided. Specific focus is placed on adolescents (i.e., middle and high school–age children). Results SLPs are critical members of the rehabilitation team working with children with mTBI and should be involved in education, symptom monitoring, and assessment early in the recovery process. SLPs can also provide unique insight into the cognitive and linguistic challenges of these students and can serve to bridge the gap among rehabilitation and school-based professionals, the adolescent with brain injury, and their parents. Conclusion The guidelines provided by the CDC, along with evidence from the field of speech pathology, can guide SLPs to advocate for involvement in the care of adolescents with mTBI. More research is needed to enhance the evidence base for direct assessment and treatment with this population; however, SLPs can use their extensive knowledge and experience working with individuals with traumatic brain injury as a starting point for post-mTBI care.

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