The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease

2016 ◽  
Vol 614 ◽  
pp. 43-48 ◽  
Author(s):  
Jin Lu ◽  
Jianliang Fu ◽  
Yuan Zhong ◽  
Pengguo Chen ◽  
Quanjun Yang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Han Chinese ◽  
Individualized Therapy ◽  
Chinese Patients

scholarly journals Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese

2018 ◽  
Vol 6 (2) ◽  
pp. 257-274 ◽  
Author(s):  
Deng-Feng Zhang ◽  
Yu Fan ◽  
Min Xu ◽  
Guihong Wang ◽  
Dong Wang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Odds Ratio ◽  
Memory Performance ◽  
Disease Onset ◽  
Missense Variant ◽  
Han Chinese ◽  
Population Heterogeneity ◽  
Chinese Patients ◽  
Risk Gene

Abstract Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability and population heterogeneity. In this study, we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease, followed by independent validation, imaging analysis and function characterization. We identified an exome-wide significant rare missense variant rs3792646 (p.K420Q) in the C7 gene in the discovery stage (P = 1.09 × 10−6, odds ratio = 7.853) and confirmed the association in different cohorts and a combined sample (1615 cases and 2832 controls, Pcombined = 2.99 × 10−7, odds ratio = 1.930). The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood, thus resulting in an earlier age of disease onset. Overexpression of the mutant p.K420Q disturbed cell viability, immune activation and β-amyloid processing. Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons. These findings suggested that C7 is a novel risk gene for Alzheimer's disease in Han Chinese.

Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease

2010 ◽  
Vol 411 (19-20) ◽  
pp. 1516-1519 ◽  
Author(s):  
Jin-Tai Yu ◽  
Lu Li ◽  
Qi-Xiu Zhu ◽  
Qun Zhang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphisms ◽  
Chinese Patients

Association of TOMM40 Polymorphisms with Late-Onset Alzheimer’s Disease in a Northern Han Chinese Population

2013 ◽  
Vol 15 (2) ◽  
pp. 279-287 ◽  
Author(s):  
Xiao-Ying Ma ◽  
Jin-Tai Yu ◽  
Wei Wang ◽  
Hui-Fu Wang ◽  
Qiu-Yan Liu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Population ◽  
Late Onset ◽  
Han Chinese ◽  
Han Chinese Population

Intron 2 (T/C) CYP46 Polymorphism Is Associated with Alzheimer’s Disease in Chinese Patients

2006 ◽  
Vol 22 (5-6) ◽  
pp. 399-404 ◽  
Author(s):  
Y. Li ◽  
L.W. Chu ◽  
Y.Q. Chen ◽  
B.M.Y. Cheung ◽  
R.Y.H Leung ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Patients ◽  
Intron 2

Association between COMT gene polymorphisms, clinical symptoms, and cognitive functions in Han Chinese patients with schizophrenia

2018 ◽  
Vol 28 (3) ◽  
pp. 47-54 ◽  
Author(s):  
Zuoli Sun ◽  
Zhengrong Zhang ◽  
Peixian Mao ◽  
Yun Ma ◽  
Wenbiao Li ◽  
...  
Keyword(s):  
Cognitive Functions ◽  
Gene Polymorphisms ◽  
Clinical Symptoms ◽  
Han Chinese ◽  
Comt Gene ◽  
Chinese Patients

Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese

2011 ◽  
Vol 491 (1) ◽  
pp. 83-86 ◽  
Author(s):  
Nan-Nan Yu ◽  
Jin-Tai Yu ◽  
Jian-Ting Xiao ◽  
Hao-Wen Zhang ◽  
Rui-Chun Lu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Han Chinese ◽  
Gene Variants
Sign in / Sign up

Export Citation Format

Share Document