scholarly journals Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors

2019 ◽  
Vol 711 ◽  
pp. 134456
Author(s):  
Elisabetta Perdona ◽  
Palmina Cavallini ◽  
Anna Sava ◽  
Cristiana Griffante ◽  
Daniel J. Ricca ◽  
...  
Keyword(s):  
Nk1 Receptors

scholarly journals Endothelium-dependent contraction mediated by NK1 receptors in rabbit intrapulmonary arteries.

1994 ◽  
Vol 64 ◽  
pp. 275
Author(s):  
Mamoru Kanda ◽  
Kazuyoshi Kurahashi ◽  
Hiroaki Shirahase ◽  
Hachiro Usui ◽  
Shohei Nakamura ◽  
...  
Keyword(s):  
Nk1 Receptors

Involvement of NK1 receptors in synaptic transmission in the guinea pig coeliac ganglion

1993 ◽  
Vol 18 (3) ◽  
pp. 245-248 ◽  
Author(s):  
F.-Y. Zhao ◽  
K. Saito ◽  
S. Konishi ◽  
J.-Z. Guo ◽  
T. Murakoshi ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Synaptic Transmission ◽  
Nk1 Receptors

scholarly journals Comparative studies on peptides representing the so-called tachykinin-like region of the Alzheimer Aβ peptide [Aβ(25–35)]

1998 ◽  
Vol 336 (2) ◽  
pp. 419-427 ◽  
Author(s):  
Omar M. A. EL-AGNAF ◽  
G. Brent IRVINE ◽  
Geraldine FITZPATRICK ◽  
W. Kenneth GLASS ◽  
David J. S. GUTHRIE
Keyword(s):  
Electron Microscopy ◽  
Ligand Binding ◽  
Comparative Studies ◽  
Aβ Peptide ◽  
Amyloid Protein ◽  
Binding Studies ◽  
Nk1 Receptors ◽  
Ligand Displacement ◽  
Β Amyloid

In an attempt to answer the question of whether or not the so-called tachykinin-like region of the Alzheimer β-amyloid protein [Aβ(25–35)] can act as a tachykinin, the sequences Aβ(25–35), Aβ(25–35)amide and their norleucine-35 and phenylalanine-31 analogues were synthesized. These peptides were examined with ligand binding studies, electron microscopy, CD and NMR. In all cases some differences were found between the Aβ(25–35) analogue and the corresponding Phe31 peptide. In addition, in ligand displacement studies on tachykinin NK1 receptors, only the Phe31 analogue showed activity comparable to that of genuine tachykinins. We conclude that peptides based on Aβ(25–35) but with a Phe residue at position 31 do display properties typical of a tachykinin, but that peptides with Ile at this position do not.

Signaling pathways via NK1 receptors and their desensitization in an AR42J cell line

Peptides ◽  
1998 ◽  
Vol 19 (8) ◽  
pp. 1349-1357 ◽  
Author(s):  
Shigetomo Fukuhara ◽  
Midori Shimizu ◽  
Hironori Matsushima ◽  
Hidehito Mukai ◽  
Eisuke Munekata
Keyword(s):  
Signaling Pathways ◽  
Cell Line ◽  
Nk1 Receptors ◽  
Ar42j Cell
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