Detection of behavioral alterations and learning deficits in mouse model of Alzheimer's disease expressing the mutant human presenilin 2 using a comprehensive behavioral test battery

2011 ◽  
Vol 71 ◽  
pp. e181
Author(s):  
Yasushi Kishimoto ◽  
Akira Nagao ◽  
Erina Higashihara ◽  
Akiko Fukuda ◽  
Yutaka Kirino
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Test Battery ◽  
Behavioral Alterations ◽  
Behavioral Test ◽  
Learning Deficits ◽  
Behavioral Test Battery ◽  
Model Of Alzheimer’S Disease ◽  
Presenilin 2

scholarly journals Presenilin-2 Mutation Causes Early Amyloid Accumulation and Memory Impairment in a Transgenic Mouse Model of Alzheimer's Disease

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Toshihiko Toda ◽  
Yoshihiro Noda ◽  
Genzo Ito ◽  
Masahiro Maeda ◽  
Takahiko Shimizu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Memory Impairment ◽  
Amyloid Β Protein ◽  
Model Of Alzheimer’S Disease ◽  
Amyloid Accumulation ◽  
Presenilin 2 ◽  
Tg2576 Mice

In order to clarify the pathophysiological role of presenilin-2 (PS2) carrying the Volga German Kindred mutation (N141I) in a conventional mouse model of Alzheimer's disease (AD) expressing amyloid precursor protein (APP) with the Swedish mutation (Tg2576 line), we generated a double transgenic mouse (PS2Tg2576) by crossbreeding the PS2 mutant with Tg2576 mice. Here, we demonstrate that the PS2 mutation induced the early deposition of amyloid β-protein (Aβ) at 2-3 months of age and progressive accumulation at 4-5 months of age in the brains of the mutant mice. The PS2 mutation also accelerated learning and memory impairment associated with Aβ accumulation at 4-5 months of age in Tg2576 mice. These results suggest that the PS2 mutation causes early cerebral amyloid accumulation and memory dysfunction. PS2Tg2576 mice are a suitable mouse model for studying amyloid-lowering therapies.

P4-037: Novel age-dependent learning deficits in a mouse model of Alzheimer's disease: Implications for translational research

2009 ◽  
Vol 5 (4S_Part_14) ◽  
pp. P442-P442
Author(s):  
Karienn S. Montgomery ◽  
Rebecca K. Simmons ◽  
George A. Edwards ◽  
Michele M. Nicolle ◽  
Mark A. Gluck ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Translational Research ◽  
Learning Deficits ◽  
Model Of Alzheimer’S Disease ◽  
Age Dependent ◽  
Dependent Learning
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