Muscarinic receptor-mediated GTP–Eu binding in the hippocampus and prefrontal cortex is correlated with spatial memory impairment in aged rats

2007 ◽  
Vol 28 (4) ◽  
pp. 619-626 ◽  
Author(s):  
Hai-Yan Zhang ◽  
Mona L. Watson ◽  
Michela Gallagher ◽  
Michelle M. Nicolle
Keyword(s):  
Prefrontal Cortex ◽  
Spatial Memory ◽  
Muscarinic Receptor ◽  
Memory Impairment ◽  
Aged Rats

scholarly journals Animal models of memory impairment

1997 ◽  
Vol 352 (1362) ◽  
pp. 1711-1717 ◽  
Author(s):  
◽  
Michela Gallagher
Keyword(s):  
Animal Models ◽  
Spatial Memory ◽  
Memory Impairment ◽  
Structural Integrity ◽  
Hippocampal Formation ◽  
Cholinergic Neurons ◽  
The Elderly ◽  
Aged Rats ◽  
Young Rats ◽  
Age Related

Memory impairment in the elderly resembles a mild temporal lobe dysfunction. Alterations in the hippocampal formation are also a probable basis for cognitive deficits in some animal models of ageing. For example, aged rats are impaired in hippocampal-dependent tests of spatial memory. Recent studies have revealed considerable structural integrity in the aged hippocampus, even in aged rats with the most impaired spatial memory. In contrast, atrophy/loss of cholinergic neurons in the basal forebrain and deficiency in cholinergic transduction in hippocampus correlate with the severity of spatial memory impairment in aged rats. This evidence supports the longstanding view that age-related loss of memory has a cholinergic basis. In this context, it is somewhat surprising that the use of a selective cholinergic immunotoxin in young rats to further test this hypothesis has revealed normal spatial memory after removing septo-hippocampal cholinergic neurons. Young rats with immunotoxic lesions, however, have other behavioural impairments in tests of attentional processing. These lines of research have implications for understanding the neurobiological basis of memory deficits in ageing and for selecting an optimal behavioural setting in which to examine therapies aimed at restoring neurobiological function.

Loss of NGF receptor immunoreactivity in basal forebrain neurons of aged rats: correlation with spatial memory impairment

1989 ◽  
Vol 498 (2) ◽  
pp. 397-404 ◽  
Author(s):  
Sookyong Koh ◽  
Philip Chang ◽  
Timothy J. Collier ◽  
Rebekah Loy
Keyword(s):  
Spatial Memory ◽  
Basal Forebrain ◽  
Memory Impairment ◽  
Aged Rats ◽  
Ngf Receptor ◽  
Forebrain Neurons

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

Nature ◽  
1987 ◽  
Vol 329 (6134) ◽  
pp. 65-68 ◽  
Author(s):  
W. Fischer ◽  
K. Wictorin ◽  
A. Björklund ◽  
L. R. Williams ◽  
S. Varon ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Spatial Memory ◽  
Memory Impairment ◽  
Cholinergic Neuron ◽  
Aged Rats ◽  
Nerve Growth

Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats

2012 ◽  
Vol 56 (5) ◽  
pp. 601-607 ◽  
Author(s):  
M. GONG ◽  
G. CHEN ◽  
X. M. ZHANG ◽  
L. H. XU ◽  
H. M. WANG ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Aged Rats ◽  
Sevoflurane Anesthesia

Sensitivity to cholinergic drug treatments of aged rats with variable degrees of spatial memory impairment

1998 ◽  
Vol 98 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Jeanne Stemmelin ◽  
Jean-Christophe Cassel ◽  
Bruno Will ◽  
Christian Kelche
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Aged Rats ◽  
Drug Treatments ◽  
Cholinergic Drug
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