Dissociable contributions of the mid-ventrolateral frontal cortex and the medial temporal lobe system to human memory

NeuroImage ◽  
2006 ◽  
Vol 31 (4) ◽  
pp. 1790-1801 ◽  
Author(s):  
Anja Dove ◽  
Matthew Brett ◽  
Rhodri Cusack ◽  
Adrian M. Owen
Keyword(s):  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Human Memory

Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss

Hippocampus ◽  
2008 ◽  
Vol 18 (5) ◽  
pp. 440-444 ◽  
Author(s):  
Matthew Goddard ◽  
Yiwen Zheng ◽  
Cynthia L. Darlington ◽  
Paul F. Smith
Keyword(s):  
Protein Expression ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Synaptic Protein ◽  
Vestibular Loss ◽  
Bilateral Vestibular Loss

scholarly journals What can narratives tell us about the neural bases of human memory?

2020 ◽  
Author(s):  
Hongmi Lee ◽  
Buddhika Bellana ◽  
janice chen
Keyword(s):  
Temporal Lobe ◽  
Neural Activity ◽  
Default Mode Network ◽  
Medial Temporal Lobe ◽  
Activity Patterns ◽  
Human Memory ◽  
Memory System ◽  
Situation Models ◽  
Neural Synchrony ◽  
Default Mode

Narratives are increasingly used to study naturalistic human memory and its brain mechanisms. Narratives—audiovisual movies, spoken stories, and written stories—consist of multiple inter-related and temporally unfolding events which are rich in semantic and emotional content. These characteristics drive intersubject neural synchrony in the default mode network, where abstract situation models are represented and reinstated. Medial temporal lobe structures interact with the cortical sub-regions of the default mode network to support the encoding and recall of narrative events. Narrative memories are frequently communicated across individuals, resulting in the transmission of experiences and neural activity patterns between people. Recent advances in neuroimaging and naturalistic stimulus analysis provide valuable insights into narrative memory and the human memory system in general.

Intracranial Recordings Demonstrate Both Cortical and Medial Temporal Lobe Engagement in Visual Search in Humans

2021 ◽  
pp. 1-29
Author(s):  
S. J. Katarina Slama ◽  
Richard Jimenez ◽  
Sujayam Saha ◽  
David King-Stephens ◽  
Kenneth D. Laxer ◽  
...  
Keyword(s):  
Visual Search ◽  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Association Cortex ◽  
Subcortical Structures ◽  
Spatiotemporal Resolution ◽  
Activity Increase ◽  
Anatomical Space ◽  
Intracranial Recordings

Abstract Visual search is a fundamental human behavior, providing a gateway to understanding other sensory domains as well as the role of search in higher-order cognition. Search has been proposed to include two component processes: inefficient search (search) and efficient search (pop-out). According to extant research, these two processes map onto two separable neural systems located in the frontal and parietal association cortices. In this study, we use intracranial recordings from 23 participants to delineate the neural correlates of search and pop-out with an unprecedented combination of spatiotemporal resolution and coverage across cortical and subcortical structures. First, we demonstrate a role for the medial temporal lobe in visual search, on par with engagement in frontal and parietal association cortex. Second, we show a gradient of increasing engagement over anatomical space from dorsal to ventral lateral frontal cortex. Third, we confirm previous intracranial work demonstrating nearly complete overlap in neural engagement across cortical regions in search and pop-out. We further demonstrate pop-out selectivity, manifesting as activity increase in pop-out as compared to search, in a distributed set of sites including frontal cortex. This result is at odds with the view that pop-out is implemented in low-level visual cortex or parietal cortex alone. Finally, we affirm a central role for the right lateral frontal cortex in search.

Remembering

Daedalus ◽  
2015 ◽  
Vol 144 (1) ◽  
pp. 53-66 ◽  
Author(s):  
Larry R. Squire ◽  
John T. Wixted
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Human Memory ◽  
Memory Systems ◽  
Consolidation Process ◽  
Multiple Memory Systems ◽  
Memory Work ◽  
Major Development ◽  
The Brain

A major development in understanding the structure and organization of memory was the identification of the medial temporal lobe memory system as one of the brain systems that support memory. Work on this topic began in the 1950s with the study of the noted amnesic patient H.M. and culminated in studies of an animal model of human memory impairment in the nonhuman primate. These discoveries opened new frontiers of research concerned with the functional specialization of structures within the medial temporal lobe, the existence of multiple memory systems, the process of memory consolidation, and the role of neural replay and sleep in the consolidation process. This work also led to new insights about how and where memories are ultimately stored in the brain. All of this research has improved our understanding of how memory is affected by normal aging and why it is so profoundly impaired by the pathological processes associated with dementia.

scholarly journals Theta Oscillations Mediate Interaction between Prefrontal Cortex and Medial Temporal Lobe in Human Memory

2009 ◽  
Vol 20 (7) ◽  
pp. 1604-1612 ◽  
Author(s):  
Kristopher L. Anderson ◽  
Rajasimhan Rajagovindan ◽  
Georges A. Ghacibeh ◽  
Kimford J. Meador ◽  
Mingzhou Ding
Keyword(s):  
Prefrontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Human Memory ◽  
Theta Oscillations

scholarly journals Right medial temporal–lobe contribution to object–location memory

1997 ◽  
Vol 352 (1360) ◽  
pp. 1469-1474 ◽  
Author(s):  
Brenda Milner ◽  
Ingrid Johnsrude ◽  
Joelle Crane
Keyword(s):  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Anterior Part ◽  
Human Memory ◽  
Learning Task ◽  
Temporal Lobectomy ◽  
Object Location ◽  
Parahippocampal Gyrus ◽  
Location Memory ◽  
Positron Emission

An important aspect of normal human memory, and one humans share with many other species, is the ability to remember the location of objects in their environment. There is by now strong evidence from the study of epileptic patients undergoing brain surgery that right temporal–lobe lesions that encroach extensively upon the hippocampal and parahippocampal gyrus impair the delayed, but not the immediate, recall of the location of objects within a random array. These findings have now been extended to a multiple–trial, spatial–array learning task; by including not only patients tested after unilateral anterior temporal lobectomy but also those with a selective left or right amygdalohippocampectomy, it has been shown that the deficits associated with right hippocampal lesions are not dependent upon conjoint damage to the lateral temporal neocortex. Furthermore, the fact that on the learning task no group differences were seen on Trial 1, at zero delay, strengthened the view that the impairment was in the maintenance and subsequent retrieval of information rather than in its initial encoding. These results left unresolved the question of whether the deficit was in the mediation of object–place associations or whether it could be reduced to a more general impairment in memory for location as such. Also left unanswered was the neuroanatomical question as to the relative contributions of the hippocampus and the parahippocampal gyrus to the performance of the experimental tasks. These questions were addressed in two blood–flow activation studies that made use of positron emission tomography (PET) and magnetic resonance imaging (MRI) and incorporated computerized versions of object–location and simple–location memory tasks. Taken together, the results point to a special contribution from the anterior part of the right parahippocampal gyrus, probably corresponding to the entorhinal cortex, to the retrieval of object–place associations, a result consonant with neurophysiological findings in non–human primates.

scholarly journals Hemispheric Specialization in Human Dorsal Frontal Cortex and Medial Temporal Lobe for Verbal and Nonverbal Memory Encoding

Neuron ◽  
1998 ◽  
Vol 20 (5) ◽  
pp. 927-936 ◽  
Author(s):  
William M Kelley ◽  
Francis M Miezin ◽  
Kathleen B McDermott ◽  
Randy L Buckner ◽  
Marcus E Raichle ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Hemispheric Specialization ◽  
Memory Encoding ◽  
Nonverbal Memory
Sign in / Sign up

Export Citation Format

Share Document