Feasibility of mapping the tissue mass corrected bioscale of cerebral metabolic rate of oxygen consumption using 17-oxygen and 23-sodium MR imaging in a human brain at 9.4T

NeuroImage ◽  
2010 ◽  
Vol 51 (2) ◽  
pp. 723-733 ◽  
Author(s):  
Ian C. Atkinson ◽  
Keith R. Thulborn
Keyword(s):  
Oxygen Consumption ◽  
Mr Imaging ◽  
Human Brain ◽  
Metabolic Rate ◽  
Tissue Mass ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

METABOLIC REFERENCE STANDARDS FOR THE NEONATE

PEDIATRICS ◽  
1967 ◽  
Vol 39 (5) ◽  
pp. 724-732
Author(s):  
John C. Sinclair ◽  
Jon W. Scopes ◽  
William A. Silverman
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Extracellular Fluid ◽  
Mean Value ◽  
Reference Standards ◽  
Contributory Factor ◽  
Tissue Mass ◽  
Rate Of Oxygen Consumption

Oxygen consumption of 92 normally grown newborn babies of birth weight 750 to 3,940 gm has been expressed in terms of various metabolic reference standards in order to identify any systematic variation in expression of metabolic rate that is introduced by these bases of reference in the newborn population. It is postulated that differences in body composition comprise a contributory factor to the variation among newborn babies in rate of oxygen consumption per kilogram body weight. The predictive error from a mean value is increased if surface area, body weight, or fat-free body weight is substituted for body weight as a metabolic reference standard. By taking into account known changes in body composition of the fetus with increasing maturity, a compartment representing the active tissue mass is calculated. This corresponds closely to body weight minus extracellular fluid and includes fat. Rate of oxygen consumption is proportional to the size of this compartment over the range of body weights studied. Implications are discussed as to the metabolic rate of adipose tissue in the newborn and body composition among undergrown babies.

scholarly journals Dual-calibrated fMRI measurement of absolute cerebral metabolic rate of oxygen consumption and effective oxygen diffusivity

NeuroImage ◽  
2019 ◽  
Vol 184 ◽  
pp. 717-728 ◽  
Author(s):  
M. Germuska ◽  
H.L. Chandler ◽  
R.C. Stickland ◽  
C. Foster ◽  
F. Fasano ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Oxygen Diffusivity ◽  
Rate Of Oxygen Consumption ◽  
Calibrated Fmri

scholarly journals Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia

2011 ◽  
Vol 31 (7) ◽  
pp. 1504-1512 ◽  
Author(s):  
Varsha Jain ◽  
Michael C Langham ◽  
Thomas F Floyd ◽  
Gaurav Jain ◽  
Jeremy F Magland ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Oxygen Consumption ◽  
Magnetic Resonance ◽  
Metabolic Rate ◽  
Vascular Reactivity ◽  
Cerebral Metabolism ◽  
Metabolic Effects ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption ◽  
End Tidal

The effect of hypercapnia on cerebral metabolic rate of oxygen consumption ( CMRO2) has been a subject of intensive investigation and debate. Most applications of hypercapnia are based on the assumption that a mild increase in partial pressure of carbon dioxide has negligible effect on cerebral metabolism. In this study, we sought to further investigate the vascular and metabolic effects of hypercapnia by simultaneously measuring global venous oxygen saturation ( Sv O2) and total cerebral blood flow ( tCBF), with a temporal resolution of 30 seconds using magnetic resonance susceptometry and phase-contrast techniques in 10 healthy awake adults. While significant increases in Sv O2 and tCBF were observed during hypercapnia ( P < 0.005), no change in CMRO2 was noted ( P > 0.05). Additionally, fractional changes in tCBF and end-tidal carbon dioxide ( R2 = 0.72, P < 0.005), as well as baseline Sv O2 and tCBF ( R2 = 0.72, P < 0.005), were found to be correlated. The data also suggested a correlation between cerebral vascular reactivity ( CVR) and baseline tCBF ( R2 = 0.44, P = 0.052). A CVR value of 6.1% ± 1.6%/mm Hg was determined using a linear-fit model. Additionally, an average undershoot of 6.7% ± 4% and 17.1% ± 7% was observed in Sv O2 and tCBF upon recovery from hypercapnia in six subjects.

scholarly journals Multiplexed MRI methods for rapid estimation of global cerebral metabolic rate of oxygen consumption

NeuroImage ◽  
2017 ◽  
Vol 149 ◽  
pp. 393-403 ◽  
Author(s):  
Hyunyeol Lee ◽  
Michael C. Langham ◽  
Ana E. Rodriguez-Soto ◽  
Felix W. Wehrli
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Rapid Estimation ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

scholarly journals Estimation of the regional cerebral metabolic rate of oxygen consumption with proton detected 17O MRI during precision 17O2 inhalation in swine

2009 ◽  
Vol 179 (1) ◽  
pp. 29-39 ◽  
Author(s):  
Eric A. Mellon ◽  
R. Shashank Beesam ◽  
James E. Baumgardner ◽  
Arijitt Borthakur ◽  
Walter R. Witschey ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption

Sleep-dependent changes in the cerebral metabolic rate of oxygen consumption in newborn lambs

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S85-S85
Author(s):  
Alessandro Silvani ◽  
Valentina Asti ◽  
Chiara Berteotti ◽  
Tijana Bojic ◽  
Vera Ferrari ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Cerebral Metabolic Rate ◽  
Rate Of Oxygen Consumption
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