scholarly journals The effect of white matter hyperintensities on regional brain volumes and white matter microstructure, a population-based study in HUNT

NeuroImage ◽  
2019 ◽  
Vol 203 ◽  
pp. 116158 ◽  
Author(s):  
Torgil Riise Vangberg ◽  
Live Eikenes ◽  
Asta K. Håberg
Keyword(s):  
White Matter ◽  
White Matter Hyperintensities ◽  
Population Based ◽  
Population Based Study ◽  
Brain Volumes ◽  
Regional Brain ◽  
White Matter Microstructure

Regional brain volumes, microstructure and neurodevelopment in moderate–late preterm children

2020 ◽  
Vol 105 (6) ◽  
pp. 593-599 ◽  
Author(s):  
Claire E Kelly ◽  
Deanne K Thompson ◽  
Alicia J Spittle ◽  
Jian Chen ◽  
Marc L Seal ◽  
...  
Keyword(s):  
White Matter ◽  
Grey Matter ◽  
Diffusion Tensor ◽  
Brain Mri ◽  
Developmental Outcomes ◽  
Late Preterm ◽  
Brain Volumes ◽  
Regional Brain ◽  
White Matter Microstructure ◽  
Cortical Grey Matter

ObjectiveTo explore whether regional brain volume and white matter microstructure at term-equivalent age (TEA) are associated with development at 2 years of age in children born moderate–late preterm (MLPT).Study designA cohort of MLPT infants had brain MRI at approximately TEA (38–44 weeks’ postmenstrual age) and had a developmental assessment (Bayley Scales of Infant and Toddler Development and Infant Toddler Social Emotional Assessment) at 2 years’ corrected age. Relationships between cortical grey matter and white matter volumes and 2-year developmental outcomes were explored using voxel-based morphometry. Relationships between diffusion tensor measures of white matter microstructure (fractional anisotropy (FA) and axial (AD), radial (RD) and mean (MD) diffusivities) and 2-year developmental outcomes were explored using tract-based spatial statistics.Results189 MLPT children had data from at least one MRI modality (volumetric or diffusion) and data for at least one developmental domain. Larger cortical grey and white matter volumes in many brain regions, and higher FA and lower AD, RD and MD in several major white matter regions, were associated with better cognitive and language scores. There was little evidence that cortical grey matter and white matter volumes and white matter microstructure were associated with motor and behavioural outcomes.ConclusionsRegional cortical grey matter and white matter volumes and white matter microstructure are associated with cognitive and language development at 2 years of age in MLPT children. Thus, early alterations to brain volumes and microstructure may contribute to some of the developmental deficits described in MLPT children.

scholarly journals Association between homocysteine and white matter hyperintensities in asymptomatic intracranial arterial stenosis: results from a population-based study

2019 ◽  
Author(s):  
Hao Yin ◽  
Xiang Wang ◽  
Yuan-yuan Zhao ◽  
Xiao-kang Ji ◽  
Shao-wei Sang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Hyperintensities ◽  
Population Based ◽  
Arterial Stenosis ◽  
Chinese People ◽  
Intracranial Arterial Stenosis ◽  
Population Based Study

Abstract Background: Although homocysteine (Hcy) and white matter hyperintensities (WMH) have been proven to be correlated with increased risks of ischemic stroke, there have been few studies addressing the association between serum Hcy and WMH in a population with asymptomatic intracranial arterial stenosis (aICAS). Thus, the aim of the present study is to describe the association between Hcy and WMH in rural-dwelling Chinese people with aICAS. Methods: In this study, 150 participants diagnosed as aICAS by magnetic resonance angiography were recruited from the Kongcun Town Study, which was a population-based study aimed to investigate the prevalence of aICAS in general population aged 40 to 90 years old, free of ischemic stroke history, and living in the Kongcun town, Pingyin county, Shandong, China. Data on demographics, risk factors, and serum Hcy levels were collected via interview, clinical examination, and laboratory tests. The WMH volumes were calculated through the lesion segmentation tool system for the Statistical Parametric Mapping package based on magnetic resonance imaging. The association between Hcy and WMH volume was analyzed using both linear and logistic regression analysis. Results: After adjusting for all confounders, high Hcy (HHcy) (serum Hcy ≥15umol/L) was significantly associated with severe WMH (the highest quartile in WMH volume) (OR: 2.972, 95%CI: 1.017-7.979, P <0.05). However, with changing of WMH volumes, only trends towards association with HHcy were observed in all 3 models (P values only slightly exceeded 0.05). After being stratified by age, sex, or ever smoking, the association between HHcy and WMH became more significant in participants who were ≥60 years old, male, or ever smoker. Conclusions: HHcy is associated with severe WMH in rural-dwelling Chinese people with aICAS, especially in participants ≥60 years old, male participants, or ever smokers, indicating these may be risk factors that contribute to the association between HHcy and severe WMH.

Relationship between trust in neighbors and regional brain volumes in a population-based study

2019 ◽  
Vol 286 ◽  
pp. 11-17
Author(s):  
Mohona Sadhu ◽  
Theresa de Freitas Nicholson ◽  
Rogelio Garcia ◽  
Susana Lampley ◽  
Marian Rain ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Brain Volumes ◽  
Regional Brain

O1-04-05: Hypertension, APOE-ɛ4 allele, regional white-matter hyperintensities, and cognitive decline in old age: A population-based study

2015 ◽  
Vol 11 (7S_Part_3) ◽  
pp. P134-P134
Author(s):  
Chengxuan Qiu ◽  
Anna Laveskog ◽  
Rui Wang ◽  
Lena Bronge ◽  
Lars-Olof Wahlund ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Decline ◽  
Old Age ◽  
White Matter Hyperintensities ◽  
Population Based ◽  
Population Based Study ◽  
E4 Allele

scholarly journals White Matter Hyperintensities and the Progression of Frailty—The Tasmanian Study of Cognition and Gait

2020 ◽  
Vol 75 (8) ◽  
pp. 1545-1550
Author(s):  
Timothy P Siejka ◽  
Velandai K Srikanth ◽  
Ruth E Hubbard ◽  
Chris Moran ◽  
Richard Beare ◽  
...  
Keyword(s):  
White Matter ◽  
Mixed Models ◽  
White Matter Hyperintensities ◽  
Small Vessel Disease ◽  
Frailty Index ◽  
Brain Magnetic Resonance Imaging ◽  
Population Based ◽  
White Matter Hyperintensity ◽  
Intracranial Volume ◽  
Population Based Study

Abstract Background The contribution of cerebral small vessel disease (cSVD) to the pathogenesis of frailty remains uncertain. We aimed to examine the associations between cSVD with progression of frailty in a population-based study of older people. Methods People aged between 60 and 85 years were randomly selected form the electoral roll to participate in the Tasmanian Study of Cognition and Gait. Participants underwent self-reported questionnaires, objective gait, cognitive and sensorimotor testing over three phases ranging between 2005 and 2012. These data were used to calculate a 41-item frailty index (FI) at three time points. Baseline brain magnetic resonance imaging was performed on all participants to measure cSVD. Generalized mixed models were used to examine associations between baseline cSVD and progression of frailty, adjusted for confounders of age, sex, level of education, and total intracranial volume. Results At baseline (n = 388) mean age was 72 years (SD = 7.0), 44% were female, and the median FI score was 0.20 (interquartile range [IQR] 0.12, 0.27). In fully adjusted models higher burden of baseline white matter hyperintensity (WMH) was associated with frailty progression over 4.4 years (β = 0.03, 95% CI: 0.01, 0.05; p = .004) independent of other SVD markers. Neither baseline infarcts (p = .23), nor microbleeds at baseline (p = .65) were associated with progression of frailty. Conclusions We provide evidence for an association between baseline WMHs and progression of frailty. Our findings add to a growing body of literature suggesting WMH is a marker for frailty.

scholarly journals Prenatal and Childhood Adverse Events and Child Brain Morphology: A Population-Based Study

2021 ◽  
Author(s):  
Andrea P. Cortes Hidalgo ◽  
Scott W. Delaney ◽  
Stavroula A. Kourtalidi ◽  
Alexander Neumann ◽  
Runyu Zou ◽  
...  
Keyword(s):  
White Matter ◽  
Adverse Events ◽  
Large Population ◽  
Population Based ◽  
Brain Morphology ◽  
Cumulative Number ◽  
Childhood Adversities ◽  
Population Based Study ◽  
Brain Volumes ◽  
Total Brain

AbstractBackgroundPrenatal and childhood adverse events have been shown to be related to children’s cognitive and psychological development. However, the influence of early-life adversities on child brain morphology is not well understood and most studies are based on small samples and often examine only one adversity. Thus, the goal of our study is to examine the relationship between cumulative exposures to prenatal and childhood adversities and brain morphology in a large population-based study.MethodsParticipants included 2,993 children in whom prenatal adversities were reported by mothers at 20-25 weeks of pregnancy and the child’s lifetime exposure to adversities was reported by mothers when the children were 10 years-of-age. The total brain, grey and white matter volumes and the volume of the cerebellum, amygdala and hippocampus were assessed with magnetic resonance imaging when children were 10 years old.ResultsIn total, 36% of children had mothers who were exposed to at least one adversity during pregnancy and 35% of children were exposed to adversities in childhood. In our study sample, the cumulative number of prenatal adversities was not related to any brain outcome. In contrast, per each additional childhood adverse event, the total brain volume was 0.07 standard deviations smaller (SE = 0.02, p = 0.001), with differences in both grey and white matter volumes. Childhood adversities were not related to the amygdala or hippocampal volumes. Additionally, the link between childhood events and the preadolescent brain was not modified by prenatal events and was not explained by maternal psychopathology.ConclusionsOur results suggest that childhood adversities, but not prenatal adverse events, are associated with smaller global brain volumes in preadolescence. Notably, this is the first large population-based study to prospectively assess the association between the cumulative number of prenatal adversities and the preadolescent brain morphology. The study findings extend the evidence from high-risk samples, providing support for a link between cumulative childhood adverse events and brain morphology in children from the general population.

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