Relationship between trust in neighbors and regional brain volumes in a population-based study

Background: Structural brain magnetic resonance imaging (MRI) scans may provide reliable neuroimaging markers for defining amnestic mild cognitive impairment (aMCI). Objective: We sought to characterize global and regional brain structures of aMCI among rural-dwelling older adults with limited education in China. Methods: This population-based study included 180 participants (aged≥65 years, 42 with aMCI and 138 normal controls) in the Shandong Yanggu Study of Aging and Dementia during 2014–2016. We defined aMCI following the Petersen’s criteria. Global and regional brain volumes were automatically segmented on MRI scans and compared using a region-of-interest approach. Data were analyzed using general linear regression models. Results: Multi-adjusted β-coefficient (95% confidence interval) of brain volumes (cm3) associated with aMCI was –12.07 (–21.49, –2.64) for global grey matter (GM), –18.31 (–28.45, –8.17) for global white matter (WM), 28.17 (12.83, 44.07) for cerebrospinal fluid (CSF), and 2.20 (0.24, 4.16) for white matter hyperintensities (WMH). Furthermore, aMCI was significantly associated with lower GM volumes in bilateral superior temporal gyri, thalamus and right cuneus, and lower WM volumes in lateral areas extending from the frontal to the parietal, temporal, and occipital lobes, as well as right hippocampus (p < 0.05). Conclusion: Brain structure of older adults with aMCI is characterized by reduced global GM and WM volumes, enlarged CSF volume, increased WMH burden, reduced GM volumes in bilateral superior temporal gyri, thalamus, and right cuneus, and widespread reductions of lateral WM volumes.

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Effect of Leukocyte Telomere Length on Total and Regional Brain Volumes in a Large Population-Based Cohort

JAMA Neurology ◽

10.1001/jamaneurol.2014.1926 ◽

2014 ◽

Vol 71 (10) ◽

pp. 1247 ◽

Cited By ~ 41

Author(s):

Kevin S. King ◽

Julia Kozlitina ◽

Roger N. Rosenberg ◽

Ronald M. Peshock ◽

Roderick W. McColl ◽

...

Keyword(s):

Telomere Length ◽

Large Population ◽

Population Based ◽

Leukocyte Telomere Length ◽

Brain Volumes ◽

Regional Brain

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Domains of physical activity and brain volumes: A population-based study

NeuroImage ◽

10.1016/j.neuroimage.2017.05.020 ◽

2017 ◽

Vol 156 ◽

pp. 101-108 ◽

Cited By ~ 4

Author(s):

Carmen Jochem ◽

Sebastian E. Baumeister ◽

Katharina Wittfeld ◽

Michael F. Leitzmann ◽

Martin Bahls ◽

...

Keyword(s):

Physical Activity ◽

Population Based ◽

Population Based Study ◽

Brain Volumes

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Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study

European Journal of Neurology ◽

10.1111/ene.12319 ◽

2013 ◽

Vol 21 (8) ◽

pp. 1076-1082 ◽

Cited By ~ 20

Author(s):

R. Wang ◽

L. Fratiglioni ◽

A. Laveskog ◽

G. Kalpouzos ◽

C.-H. Ehrenkrona ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

White Matter ◽

Cardiovascular Risk Factors ◽

Old Age ◽

White Matter Hyperintensities ◽

Population Based ◽

Population Based Study ◽

Brain Volumes

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Prenatal and Childhood Adverse Events and Child Brain Morphology: A Population-Based Study

10.1101/2021.02.25.21252442 ◽

2021 ◽

Author(s):

Andrea P. Cortes Hidalgo ◽

Scott W. Delaney ◽

Stavroula A. Kourtalidi ◽

Alexander Neumann ◽

Runyu Zou ◽

...

Keyword(s):

White Matter ◽

Adverse Events ◽

Large Population ◽

Population Based ◽

Brain Morphology ◽

Cumulative Number ◽

Childhood Adversities ◽

Population Based Study ◽

Brain Volumes ◽

Total Brain

AbstractBackgroundPrenatal and childhood adverse events have been shown to be related to children’s cognitive and psychological development. However, the influence of early-life adversities on child brain morphology is not well understood and most studies are based on small samples and often examine only one adversity. Thus, the goal of our study is to examine the relationship between cumulative exposures to prenatal and childhood adversities and brain morphology in a large population-based study.MethodsParticipants included 2,993 children in whom prenatal adversities were reported by mothers at 20-25 weeks of pregnancy and the child’s lifetime exposure to adversities was reported by mothers when the children were 10 years-of-age. The total brain, grey and white matter volumes and the volume of the cerebellum, amygdala and hippocampus were assessed with magnetic resonance imaging when children were 10 years old.ResultsIn total, 36% of children had mothers who were exposed to at least one adversity during pregnancy and 35% of children were exposed to adversities in childhood. In our study sample, the cumulative number of prenatal adversities was not related to any brain outcome. In contrast, per each additional childhood adverse event, the total brain volume was 0.07 standard deviations smaller (SE = 0.02, p = 0.001), with differences in both grey and white matter volumes. Childhood adversities were not related to the amygdala or hippocampal volumes. Additionally, the link between childhood events and the preadolescent brain was not modified by prenatal events and was not explained by maternal psychopathology.ConclusionsOur results suggest that childhood adversities, but not prenatal adverse events, are associated with smaller global brain volumes in preadolescence. Notably, this is the first large population-based study to prospectively assess the association between the cumulative number of prenatal adversities and the preadolescent brain morphology. The study findings extend the evidence from high-risk samples, providing support for a link between cumulative childhood adverse events and brain morphology in children from the general population.

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