Increased hippocampal head diffusivity predicts impaired episodic memory performance in early Alzheimer's disease

Hippocampal dysfunction and deficits in episodic memory have been reported for both Alzheimer’s disease (AD) and major depressive disorder (MDD). Primacy performance has been associated with hippocampus-dependent episodic memory, while recency may reflect working memory performance. In this study, serial position profiles were examined in a total of 73 patients with MDD, AD, both AD and MDD, and healthy controls (HC) by means of CERAD-NP word list memory. Primacy performance was most impaired in AD with comorbid MDD, followed by AD, MDD, and HC. Recency performance, on the other hand, was comparable across groups. These findings indicate that primacy in AD is impaired in the presence of comorbid MDD, suggesting additive performance decrements in this specific episodic memory function.

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P2-011: PHARMACOKINETIC-PHARMACODYNAMIC MODELING OF THE THERAPEUTIC EFFECT OF ORAL P38 MAPK ALPHA ANTAGONISM ON EPISODIC MEMORY IN PATIENTS WITH EARLY ALZHEIMER'S DISEASE (AD)

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.695 ◽

2006 ◽

Vol 14 (7S_Part_12) ◽

pp. P669-P669

Author(s):

Hui-May Chu ◽

Niels D. Prins ◽

Ene Ette ◽

John Alam

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Episodic Memory ◽

P38 Mapk ◽

Therapeutic Effect ◽

Pharmacodynamic Modeling ◽

Early Alzheimer’S Disease

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P2-481: THE TEST OF GESTURES (TEGEST) AS A NOVEL SIMPLE EVALUATION OF EPISODIC MEMORY IN EARLY ALZHEIMER'S DISEASE

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.1174 ◽

2006 ◽

Vol 14 (7S_Part_16) ◽

pp. P911-P911

Author(s):

Ales Bartos

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Episodic Memory ◽

Early Alzheimer’S Disease ◽

Simple Evaluation

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Association of neuroinflammation with episodic memory: a [11C]PBR28 PET study in cognitively discordant twin pairs

Brain Communications ◽

10.1093/braincomms/fcaa024 ◽

2020 ◽

Vol 2 (1) ◽

Author(s):

Noora Lindgren ◽

Jouni Tuisku ◽

Eero Vuoksimaa ◽

Semi Helin ◽

Mira Karrasch ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Episodic Memory ◽

Memory Performance ◽

Disease Process ◽

Standardized Uptake Value ◽

Weighted Average ◽

Translocator Protein ◽

Interindividual Variation ◽

Protein Genotype

Abstract Alzheimer’s disease is associated with chronic response of innate immune system, referred as neuroinflammation. PET radioligands binding to the 18 kDa translocator protein are potential biomarkers of neuroinflammation. Translocator protein PET studies in mild cognitive impairment and Alzheimer’s disease have indicated controversial results, possibly reflecting interindividual variation and heterogeneity of study populations. We controlled for genetic and environmental effects by studying twin pairs discordant for episodic memory performance. Episodic memory impairment is a well-known cognitive hallmark of early Alzheimer’s disease process. Eleven same-sex twin pairs (four monozygotic pairs, six female pairs, age 72–77 years) underwent [11C]N-acetyl-N-(2-methoxybenzyl)-2-phenoxy-5-pyridinamine ([11C]PBR28) PET imaging, structural magnetic resonance imaging and neuropsychological testing in 2014–17. Main PET outcome was the volume-weighted average standardized uptake value of cortical regions vulnerable to Alzheimer’s disease pathology. Ten pairs were discordant for episodic memory performance. In the eight pairs with identical translocator protein genotype, twins with poorer episodic memory had ∼20% higher cortical [11C]PBR28 binding compared with their better-performing co-twins (mean intra-pair difference 0.21 standardized uptake value, 95% confidence interval 0.05–0.37, P = 0.017). The result remained the same when including all discordant pairs and controlling for translocator protein genotype. Increased translocator protein PET signal suggests that increased microglial activation is associated with poorer episodic memory performance. Twins with worse episodic memory performance compared with their co-twins had on average 20% higher uptake of the neuroinflammatory marker translocator protein PET tracer 11[11C]PBR28. The findings support a negative association between neuroinflammation and episodic memory and the use of translocator protein positron emission tomography as a useful indicator of Alzheimer’s disease process.

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