scholarly journals A short cut to the past: Cueing via concrete objects improves autobiographical memory retrieval in Alzheimer's disease patients

2018 ◽  
Vol 110 ◽  
pp. 113-122 ◽  
Author(s):  
Marie Kirk ◽  
Dorthe Berntsen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Memory Retrieval ◽  
The Past ◽  
Concrete Objects

scholarly journals IC-O1-02: Neural underpinnings of autobiographical memory retrieval in Alzheimer's disease

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P3-P3
Author(s):  
Olga Meulenbroek ◽  
Roy P.C. Kessels ◽  
Marcel G.M. Olde Rikkert ◽  
Mark Rijpkema ◽  
Guillén Fernández
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Memory Retrieval ◽  
Neural Underpinnings

Autobiographical memory retrieval in patients with Alzheimer's disease

NeuroImage ◽  
2010 ◽  
Vol 53 (1) ◽  
pp. 331-340 ◽  
Author(s):  
Olga Meulenbroek ◽  
Mark Rijpkema ◽  
Roy P.C. Kessels ◽  
Marcel G.M. Olde Rikkert ◽  
Guillén Fernández
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Memory Retrieval

Are Deficits in Social Cognition Linked to Autobiographical Memory in Patients with Alzheimer’s Disease?

2016 ◽  
Vol 27 (4) ◽  
pp. 257-264 ◽  
Author(s):  
Johannes H. Scheidemann ◽  
Franz Petermann ◽  
Marc Schipper
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Social Cognition ◽  
Theory Of Mind ◽  
Autobiographical Memory ◽  
Positive Relationship ◽  
Neuropsychological Test ◽  
Clinical Group ◽  
Neuropsychological Test Battery ◽  
Fluency Task

Abstract. We investigated theory of mind (ToM) deficits in Alzheimer‘s disease (AD) and its possible connection to autobiographical memory (ABM). Patients and matched controls were evaluated and compared using a video-based ToM test, an autobiographical fluency task, and a neuropsychological test battery. We found that ToM deficits were positively associated with semantic ABM in the clinical group, whereas a positive relationship appeared between ToM and episodic ABM in controls. We hypothesize that this reflects the course of the disease as well as that semantic ABM is used for ToM processing, being still accessible in AD. Furthermore, we assume that it is also less efficient, which in turn leads to a specific deficit profile of social cognition.

Research of autobiographical memory: The Autobiographical Interview (AI) Method (Healthy memory and Alzheimer’s disease)

2011 ◽  
Vol 66 (4) ◽  
pp. 587-603 ◽  
Author(s):  
Ágnes Szőllősi ◽  
Anikó Kónya
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory

Levine, Svoboda és munkatársai (2002) olyan félig strukturált Önéletrajzi Interjút fejlesztettek ki az egyedi, specifikus önéletrajzi emlékek vizsgálatára, amely képes kiemelni az emlék elbeszéléséből az eseményspecifikus tartalmakat. Jelen vizsgálat célja e módszer magyar nyelvű adaptációja. Az eljárás segítségével három egészséges életkori csoport került összehasonlításra: fiatalok (20–27 év: 25 fő), középkorúak (45–55 év: 25 fő) és idősek (60–79 év: 16 fő), valamint egy emlékezetsérült klinikai betegcsoport: kezdeti stádiumú Alzheimer-kórban szenvedő betegek (60–80 év: 16 fő). Megerősítést kapott, hogy egészséges személyeknél a kor előrehaladtával romlik az önéletrajzi események elbeszélésének epizodikus gazdagsága. Továbbá, hogy az Alzheimer-kór kezdeti stádiumában sokkal nagyobb mértékben sérül az epizodikus emlékezés képessége, mint hasonló életkorú egészséges idős személyeknél.

Nanotechnology Based Delivery Systems of Drugs Currently Used to Treat Alzheimer’s Disease

2020 ◽  
Vol 10 (3) ◽  
pp. 228-247
Author(s):  
Niloufar Choubdar ◽  
Sara Avizheh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Polymeric Nanoparticles ◽  
Biological Fluids ◽  
Delivery Systems ◽  
Original Research ◽  
Sustained Drug Release ◽  
The Past ◽  
Site Of Action ◽  
Therapeutic Compound

Alzheimer’s Disease (AD) is one of the most common forms of dementia affecting over 46 million people, according to AD International. Over the past few decades, there has been considerable interest in developing nanomedicines. Using nanocarriers, the therapeutic compound could be delivered to the site of action where it gets accumulated. This accumulation, therefore, reduces the required doses for therapy. Alternatively, using nanocarriers decreases the side effects. Nanotechnology has had a great contribution in developing Drug Delivery Systems (DDS). These DDS could function as reservoirs for sustained drug release or control the pharmacokinetics and biodistribution of the drugs. In the current review, we have collected 38 original research articles using nanotechnology as DDS for the clinically used cholinesterase inhibitor drugs donepezil (DPZ), Rivastigmine (Riv), and galantamine (Gal) used for AD treatment from 2002 to 2017 from Scopus and PubMed databases. Regarding DDS used for DPZ, most of the research in recent years dealt with polymeric nanoparticles (NPs) including Poly-D, L-Lactide-Co-Glycolide (PLGA), and chitosans (CHs), then Liposomes (LPs), nanogels, and natural products, respectively. In terms of Riv most of the research performed was focused on polymeric NPs including PLGA, polylactic acid (PLA), Poly-Ε-Caprolactone (PCL), poly-alkyl-cyanoacrylates, CH, gelatin and then LPs. The highest application of NPs in regard to Gal was related to modified LPs and polymeric NPs. Polymeric NPs demonstrate safety, higher stability in biological fluids and against enzymatic metabolism, biocompatibility, bioavailability, and improved encapsulation efficacy. LPs, another major delivery system used, demonstrate biocompatibility, ease of surface modification, and amphiphilic nature.

Visual imagery: The past and future as seen by patients with Alzheimer’s disease

2019 ◽  
Vol 68 ◽  
pp. 12-22 ◽  
Author(s):  
Mohamad El Haj ◽  
Ahmed A. Moustafa ◽  
Karim Gallouj ◽  
Frédérique Robin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Imagery ◽  
The Past

ODor-evoked Autobiographical Memory in Alzheimer’s disease?

2021 ◽  
Author(s):  
Mohamad El Haj
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Autobiographical Memory ◽  
Personal Information ◽  
Disease Model ◽  
Olfactory Stimulation ◽  
Autobiographical Memories ◽  
Comprehensive Overview ◽  
Memory Decline ◽  
Stimulation Of

Abstract Objective Because memory decline is the hallmark of Alzheimer’s disease (AD), an important endeavor for both clinicians and researchers is to improve memory performances in AD. This can be pursued by olfactory stimulation of memory in patients with AD and by studying the effects of olfactory stimulation on autobiographical memory (i.e., memory for personal information). The effects of olfactory stimulation on autobiographical memory in patients with mild AD have been reported by recent research. We thus provide the first comprehensive overview of research on odor-evoked autobiographical memory in AD. We also establish the basis for solid theoretical analysis concerning the memory improvement reported by research on odor-evoked autobiographical memory in AD. Method We examined literature on odor-evoked autobiographical memories in AD and propose the “OdAMA” (Odor-evoked Autobiographical Memory in Alzheimer’s disease) model. Results and discussion According to OdAMA model, odor exposure activates involuntary access to specific autobiographical memories, which promotes enhanced experience subjective of retrieval in patients with AD and improves their ability to construct not only recent and remote events but also future ones. The OdAMA model could serve as a guide for researchers and clinicians interested in odor-evoked autobiographical memory in AD.

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