scholarly journals Daily life activities in patients with Alzheimer’s disease or semantic dementia: Multitasking assessment

2021 ◽  
Vol 150 ◽  
pp. 107714
Author(s):  
Christophe Jarry ◽  
François Osiurak ◽  
Josselin Baumard ◽  
Mathieu Lesourd ◽  
Clémence Coiffard ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Daily Life ◽  
Semantic Dementia ◽  
Daily Life Activities

scholarly journals The Effect of Light on Daily Life Activities and Sleep in Patients with Alzheimer’s Disease

2019 ◽  
Vol 6 (3) ◽  
pp. 59-64 ◽  
Author(s):  
Güler Balcı Alparslan ◽  
Ayşe Özkaraman ◽  
Demet Özbabalık ◽  
Ertuğrul Çolak
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Daily Life ◽  
Daily Life Activities ◽  
Effect Of Light

scholarly journals Anhedonia in Semantic Dementia—Exploring Right Hemispheric Contributions to the Loss of Pleasure

2021 ◽  
Vol 11 (8) ◽  
pp. 998
Author(s):  
Siobhán R. Shaw ◽  
Hashim El-Omar ◽  
Siddharth Ramanan ◽  
Olivier Piguet ◽  
Rebekah M. Ahmed ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Rating Scale ◽  
Right Hemisphere ◽  
Semantic Knowledge ◽  
Semantic Dementia ◽  
Anterior Cingulate ◽  
Functional Impairments ◽  
Lobe Atrophy

Semantic dementia (SD) is a younger-onset neurodegenerative disease characterised by progressive deterioration of the semantic knowledge base in the context of predominantly left-lateralised anterior temporal lobe (ATL) atrophy. Mounting evidence indicates the emergence of florid socioemotional changes in SD as atrophy encroaches into right temporal regions. How lateralisation of temporal lobe pathology impacts the hedonic experience in SD remains largely unknown yet has important implications for understanding socioemotional and functional impairments in this syndrome. Here, we explored how lateralisation of temporal lobe atrophy impacts anhedonia severity on the Snaith–Hamilton Pleasure Scale in 28 SD patients presenting with variable right- (SD-R) and left-predominant (SD-L) profiles of temporal lobe atrophy compared to that of 30 participants with Alzheimer’s disease and 30 healthy older Control participants. Relative to Controls, SD-R but not SD-L or Alzheimer’s patients showed clinically significant anhedonia, representing a clear departure from premorbid levels. Overall, anhedonia was more strongly associated with functional impairment on the Frontotemporal Dementia Functional Rating Scale and motivational changes on the Cambridge Behavioural Inventory in SD than in Alzheimer’s disease patients. Voxel-based morphometry analyses revealed that anhedonia severity correlated with reduced grey matter intensity in a restricted set of regions centred on right orbitofrontal and temporopolar cortices, bilateral posterior temporal cortices, as well as the anterior cingulate gyrus and parahippocampal gyrus, bilaterally. Finally, regression and mediation analysis indicated a unique role for right temporal lobe structures in modulating anhedonia in SD. Our findings suggest that degeneration of predominantly right-hemisphere structures deleteriously impacts the capacity to experience pleasure in SD. These findings offer important insights into hemispheric lateralisation of motivational disturbances in dementia and suggest that anhedonia may emerge at different timescales in the SD disease trajectory depending on the integrity of the right hemisphere.

scholarly journals Awareness for People With Alzheimer’s Disease: Profiles and Weekly Trajectories

2022 ◽  
Vol 13 ◽  
Author(s):  
Amandine Mayelle ◽  
Capucine Hazebrouck ◽  
Mohamad El Haj ◽  
Daniel C. Mograbi ◽  
Pascal Antoine
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Interindividual Variability ◽  
Daily Life ◽  
Self Awareness ◽  
Time Intervals ◽  
Disease Awareness ◽  
Semistructured Interviews ◽  
Short Time ◽  
Underlying Processes

Objective: To understand awareness and fluctuations of awareness in Alzheimer’s disease (AD), it is fruitful to consider the objects of awareness, e.g., cognitive functioning or recognition of the disease, as well as the mechanisms and modes of expression underlying awareness. With a holistic and discourse-centered approach, we aimed to identify different awareness profiles and test whether these profiles were stable or whether transitions from one profile to another occurred over short time intervals.Methods: Twenty-eight residents of nursing homes with a diagnosis of AD participated in four semistructured interviews at biweekly intervals. These interviews were cluster analyzed to determine profiles of awareness. A Markov chain was applied to model their fluctuation.Results: Five awareness profiles were observed that differed in terms of objects and underlying processes. Awareness proved to be quite stable for four of the five profiles. Interindividual variability in awareness was also observed through numerous different trajectories that were identified.Discussion: Self-awareness and disease awareness are characterized by profiles that vary subtly between individuals. Fluctuations in awareness underscore the need to employ assessment intervals that closely reflect daily life in institutions.

Neural basis for confrontation naming difficulty in semantic dementia and Alzheimer’s disease

2003 ◽  
Vol 87 (1) ◽  
pp. 197 ◽  
Author(s):  
C. Mcmillan ◽  
P. Moore ◽  
K. Dennis ◽  
J. Gee ◽  
M. Grossman
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Semantic Dementia ◽  
Neural Basis ◽  
Confrontation Naming

What are the Benefits of Exercise for Alzheimer’s Disease? A Systematic Review of the Past 10 Years

2015 ◽  
Vol 23 (4) ◽  
pp. 659-668 ◽  
Author(s):  
Salma S.S. Hernández ◽  
Paula F. Sandreschi ◽  
Franciele C. da Silva ◽  
Beatriz A.V. Arancibia ◽  
Rudney da Silva ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Visual Memory ◽  
Web Of Science ◽  
Daily Life Activities ◽  
The Past ◽  
Cognitive Components ◽  
Manual Search ◽  
Mesh Terms ◽  
And Performance

To identify and characterize the scientific literature on the effects of exercise on Alzheimer’s disease, research was conducted in the following databases: MEDLINE, CINAHL, Web of Science, and Scopus. These MeSH terms—“exercise”, “motor activity”, “physical fitness”, “Alzheimer disease”, and its synonyms in English—were used in the initial search to locate studies published between 2003 and 2013. After reading the 12 final articles in their entirety, two additional articles, found by a manual search, were included. Of these, 13 had beneficial results of exercise in Alzheimer’s disease. Given the results discussed here, the exercise may be important for the improvement of functionality and performance of daily life activities, neuropsychiatric disturbances, cardiovascular and cardiorespiratory fitness, functional capacity components (flexibility, agility, balance, strength), and improvements in some cognitive components such as sustained attention, visual memory, and frontal cognitive function in patients with AD.

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