Adolescent Stress Disrupts the Maturation of Anxiety-related Behaviors and Alters the Developmental Trajectory of the Prefrontal Cortex in a Sex- and Age-specific Manner

Neuroscience ◽  
2018 ◽  
Vol 390 ◽  
pp. 265-277 ◽  
Author(s):  
Chloe E. Page ◽  
Laurence Coutellier
Keyword(s):  
Prefrontal Cortex ◽  
Developmental Trajectory ◽  
Adolescent Stress ◽  
Specific Manner

scholarly journals Developmental trajectory of the prefrontal cortex: a systematic review of diffusion tensor imaging studies

2017 ◽  
Vol 12 (4) ◽  
pp. 1197-1210 ◽  
Author(s):  
Sónia S. Sousa ◽  
Edson Amaro ◽  
Alberto Crego ◽  
Óscar F. Gonçalves ◽  
Adriana Sampaio
Keyword(s):  
Systematic Review ◽  
Prefrontal Cortex ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Developmental Trajectory ◽  
Imaging Studies

scholarly journals Maternal cannabinoid exposure during lactation alters the developmental trajectory of prefrontal cortex GABA-currents in offspring

2018 ◽  
Author(s):  
Andrew F. Scheyer ◽  
Jim Wager-Miller ◽  
Anne-Laure Pelissier-Alicot ◽  
Michelle N. Murphy ◽  
Ken Mackie ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Critical Period ◽  
Illicit Drug ◽  
Perinatal Period ◽  
Developmental Trajectory ◽  
Female Rats ◽  
Perinatal Exposure ◽  
Inhibitory Neurotransmitter ◽  
Male And Female Rats ◽  
Dependent Mechanism

AbstractCannabis is the most widely used illicit drug in the world, and its usage is increasing with its widespread legalization. Use of the drug by mothers during lactation may transfer active cannabinoids to the developing offspring, altering postnatal neurodevelopment during this critical period. During early life, GABA undergoes a functional switch from an excitatory to an inhibitory neurotransmitter due to reciprocal changes in expression of the K+/Cl- co-transporters KCC2 and NKCC1. Here, we characterize the functional GABA switch in the prefrontal cortex of both male and female rats. We show that treating rat dams with Δ9-THC or a synthetic cannabinoid during early lactation (PND01-10) retards KCC2 expression and delays the GABA switch in pups of both sexes via a CB1R-dependent mechanism. Our results indicate that the developmental trajectory of GABA in PFC neurons is significantly altered by perinatal exposure to cannabinoids through lactation during the early perinatal period.

Early adolescent stress-induced changes in prefrontal cortex miRNA-135a and hippocampal miRNA-16 in male rats

2017 ◽  
Vol 59 (8) ◽  
pp. 958-969 ◽  
Author(s):  
Yuan Liu ◽  
Dexiang Liu ◽  
Jingjing Xu ◽  
Hong Jiang ◽  
Fang Pan
Keyword(s):  
Prefrontal Cortex ◽  
Male Rats ◽  
Early Adolescent ◽  
Adolescent Stress ◽  
Induced Changes
Sign in / Sign up

Export Citation Format

Share Document