Adolescent Stress Disrupts the Maturation of Anxiety-related Behaviors and Alters the Developmental Trajectory of the Prefrontal Cortex in a Sex- and Age-specific Manner

Neuroscience ◽  
2018 ◽  
Vol 390 ◽  
pp. 265-277 ◽  
Author(s):  
Chloe E. Page ◽  
Laurence Coutellier
2017 ◽  
Vol 12 (4) ◽  
pp. 1197-1210 ◽  
Author(s):  
Sónia S. Sousa ◽  
Edson Amaro ◽  
Alberto Crego ◽  
Óscar F. Gonçalves ◽  
Adriana Sampaio

2018 ◽  
Author(s):  
Andrew F. Scheyer ◽  
Jim Wager-Miller ◽  
Anne-Laure Pelissier-Alicot ◽  
Michelle N. Murphy ◽  
Ken Mackie ◽  
...  

AbstractCannabis is the most widely used illicit drug in the world, and its usage is increasing with its widespread legalization. Use of the drug by mothers during lactation may transfer active cannabinoids to the developing offspring, altering postnatal neurodevelopment during this critical period. During early life, GABA undergoes a functional switch from an excitatory to an inhibitory neurotransmitter due to reciprocal changes in expression of the K+/Cl- co-transporters KCC2 and NKCC1. Here, we characterize the functional GABA switch in the prefrontal cortex of both male and female rats. We show that treating rat dams with Δ9-THC or a synthetic cannabinoid during early lactation (PND01-10) retards KCC2 expression and delays the GABA switch in pups of both sexes via a CB1R-dependent mechanism. Our results indicate that the developmental trajectory of GABA in PFC neurons is significantly altered by perinatal exposure to cannabinoids through lactation during the early perinatal period.


2017 ◽  
Vol 59 (8) ◽  
pp. 958-969 ◽  
Author(s):  
Yuan Liu ◽  
Dexiang Liu ◽  
Jingjing Xu ◽  
Hong Jiang ◽  
Fang Pan

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