Maternal Morphine Exposure and Post-Weaning Social Isolation Impair Memory and Ventral Striatum Dopamine System in Male Offspring: Is an Enriched Environment Beneficial?

Neuroscience ◽  
2021 ◽  
Author(s):  
Neda Yazdanfar ◽  
Seyed Ali Mard ◽  
Javad Mahmoudi ◽  
Nima Bakhtiari ◽  
Alireza Sarkaki ◽  
...  
Keyword(s):  
Social Isolation ◽  
Ventral Striatum ◽  
Enriched Environment ◽  
Male Offspring ◽  
Dopamine System

scholarly journals In the Eye of the Beholder: Individual Differences in Perceived Social Isolation Predict Regional Brain Activation to Social Stimuli

2009 ◽  
Vol 21 (1) ◽  
pp. 83-92 ◽  
Author(s):  
John T. Cacioppo ◽  
Catherine J. Norris ◽  
Jean Decety ◽  
George Monteleone ◽  
Howard Nusbaum
Keyword(s):  
Individual Differences ◽  
Social Isolation ◽  
Social Perception ◽  
Ventral Striatum ◽  
Neural Responses ◽  
Social Stimuli ◽  
Social And Emotional ◽  
The Right ◽  
Perceived Social Isolation ◽  
Shed Light

Prior research has shown that perceived social isolation (loneliness) motivates people to attend to and connect with others but to do so in a self-protective and paradoxically self-defeating fashion. Although recent research has shed light on the neural correlates of social perception, cooperation, empathy, rejection, and love, little is known about how individual differences in loneliness relate to neural responses to social and emotional stimuli. Using functional magnetic resonance imaging, we show that there are at least two neural mechanisms differentiating social perception in lonely and nonlonely young adults. For pleasant depictions, lonely individuals appear to be less rewarded by social stimuli, as evidenced by weaker activation of the ventral striatum to pictures of people than of objects, whereas nonlonely individuals showed stronger activation of the ventral striatum to pictures of people than of objects. For unpleasant depictions, lonely individuals were characterized by greater activation of the visual cortex to pictures of people than of objects, suggesting that their attention is drawn more to the distress of others, whereas nonlonely individuals showed greater activation of the right and left temporo-parietal junction to pictures of people than of objects, consistent with the notion that they are more likely to reflect spontaneously on the perspective of distressed others.

Involvement of the dopamine system in the effect of chronic social isolation during adolescence on social behaviors in male C57 mice

2021 ◽  
pp. 147497
Author(s):  
Xueni Zhang ◽  
Yufeng Xun ◽  
Limin Wang ◽  
Jing Zhang ◽  
Wenjuan Hou ◽  
...  
Keyword(s):  
Social Isolation ◽  
Social Behaviors ◽  
Dopamine System

scholarly journals Enriched Environment and Social Isolation Affect Cognition Ability via Altering Excitatory and Inhibitory Synaptic Density in Mice Hippocampus

2020 ◽  
Vol 45 (10) ◽  
pp. 2417-2432
Author(s):  
Hui Wang ◽  
Xiaxia Xu ◽  
Xinxin Xu ◽  
Jing Gao ◽  
Tao Zhang
Keyword(s):  
Social Isolation ◽  
Enriched Environment ◽  
Synaptic Density

scholarly journals Cross-hemispheric dopamine projections have functional significance

2016 ◽  
Vol 113 (25) ◽  
pp. 6985-6990 ◽  
Author(s):  
Megan E. Fox ◽  
Maria A. Mikhailova ◽  
Caroline E. Bass ◽  
Pavel Takmakov ◽  
Raul R. Gainetdinov ◽  
...  
Keyword(s):  
Dopamine Release ◽  
Ventral Striatum ◽  
Dopamine Neurons ◽  
Dopamine System ◽  
Anesthetized Rats ◽  
Freely Moving ◽  
Midbrain Dopamine ◽  
Dopamine Signaling ◽  
6 Hydroxydopamine ◽  
Stimulation Of

Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson’s disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine–lesioned rats. These experiments are the first, to our knowledge, to show cross-hemispheric synchronicity in dopamine signaling and support a functional role for contralateral projections. In addition, our data reveal that psychostimulants, such as amphetamine, promote the coupling of dopamine transients between hemispheres.

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