scholarly journals Enriched Environment and Social Isolation Affect Cognition Ability via Altering Excitatory and Inhibitory Synaptic Density in Mice Hippocampus

2020 ◽  
Vol 45 (10) ◽  
pp. 2417-2432
Author(s):  
Hui Wang ◽  
Xiaxia Xu ◽  
Xinxin Xu ◽  
Jing Gao ◽  
Tao Zhang
Keyword(s):  
Social Isolation ◽  
Enriched Environment ◽  
Synaptic Density

scholarly journals Enriched environment and social isolation affect cognition ability via altering excitatory and inhibitory synaptic density in mice hippocampus

2020 ◽  
Author(s):  
Hui Wang ◽  
Xiaxia Xu ◽  
Jing Gao ◽  
Tao Zhang
Keyword(s):  
Synaptic Plasticity ◽  
Social Isolation ◽  
Field Potential ◽  
Long Term Potentiation ◽  
Underlying Mechanism ◽  
Enriched Environment ◽  
Synaptic Density ◽  
Housing Environment ◽  
Term Potentiation ◽  
Phase Amplitude

Abstract Background The purpose of the study was to examine whether the underlying mechanism of the alteration of cognitive ability and synaptic plasticity induced by the housing environment is associated with the balance of excitatory/inhibitory synaptic density. Enriched environment (EE) and social isolation (SI) are two different housing environment, and one is to give multiple sensory environments, the other is to give monotonous and lonely environment. Results Male four-week-old C57 mice were divided into three groups: CON, EE and SI. They were housed in the different cage for 3 months. Morris water maze (MWM) and novel object recognition were performed. Long term potentiation (LTP), depotentiation (DEP) and Local field potential (LFPs) were recorded in the hippocampal perforant pathway (PP) and dentate gyrus (DG). The data showed that EE enhanced the ability of spatial learning, reversal learning and memory as well as LTP/DEP in the hippocampal DG region. Meanwhile, SI reduced those abilities and the level of LTP/DEP. Moreover, there were higher couplings of both phase-amplitude and phase-phase in the EE group, and lower couplings of them in the SI group compared to that in the CON group. Western blot analysis showed that EE significantly enhanced the level of PSD-95, NR2B; however, SI reduced them but enhanced level of GABAAR. Conclusion These date suggests that the cognitive functions, synaptic plasticity and neural oscillatory patterns were significantly impacted by housing environment via possibly changing the balance of excitatory and inhibitory synaptic density.

scholarly journals Gender-Dependent Effects of Enriched Environment and Social Isolation in Ischemic Retinal Lesion in Adult Rats

2013 ◽  
Vol 14 (8) ◽  
pp. 16111-16123 ◽  
Author(s):  
Peter Kiss ◽  
Krisztina Szabadfi ◽  
Gabor Horvath ◽  
Andrea Tamas ◽  
Jozsef Farkas ◽  
...  
Keyword(s):  
Social Isolation ◽  
Enriched Environment ◽  
Adult Rats ◽  
Retinal Lesion

scholarly journals Morphometry of the effect of increased experience and training on synaptic density in area CA3 of the rat hippocampus.

1979 ◽  
Vol 27 (11) ◽  
pp. 1548-1550 ◽  
Author(s):  
R A Altschuler
Keyword(s):  
Motor Activity ◽  
Morphometric Analysis ◽  
Enriched Environment ◽  
Rat Hippocampus ◽  
Synaptic Density ◽  
Synaptic Contacts ◽  
Total Length ◽  
And Training ◽  
Area Ca3

A morphometric analysis of the effect of differential experiences on synapses was performed in area CA3 of the rat hippocampus. Two methods of quantitation that used a superimposed lattice grid were employed. In the first method squares overlying synapses were measured as a proportion of the total number of squares scanned; in the second method intersections of lattice lines with synapses were counted as a proportion of the total length of lines. Both measures showed that rats which were housed in an enriched environment and received 10 weeks of training had a significant increase in total area of synaptic contacts compared to both nonenriched controls and a croup with increased motor activity.

P.596 The effects of social isolation and enriched environment on water maze perfomance in rats with early proinflammatory lipopolysaccharide stress

2020 ◽  
Vol 40 ◽  
pp. S338-S339
Author(s):  
M. Zaichenko ◽  
A. Sharkova ◽  
V. Gruzdeva ◽  
F. Zakirov ◽  
N. Broshevitskaya ◽  
...  
Keyword(s):  
Social Isolation ◽  
Water Maze ◽  
Enriched Environment

Effects of social isolation and enriched environment on behavior of adult Swiss mice do not require hippocampal neurogenesis

2011 ◽  
Vol 225 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Cristiane Felisbino Silva ◽  
Filipe Silveira Duarte ◽  
Thereza Christina Monteiro De Lima ◽  
Cilene Lino de Oliveira
Keyword(s):  
Social Isolation ◽  
Hippocampal Neurogenesis ◽  
Enriched Environment ◽  
Swiss Mice
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