P4.19 Human IgG improves the performance of mdx mice in voluntary wheel running

2011 ◽  
Vol 21 (9-10) ◽  
pp. 710
Author(s):  
J. Zschuentzsch ◽  
G. Makosch ◽  
L. Klinge ◽  
M. Tiburcy ◽  
H. Brinkmeier ◽  
...  
Keyword(s):  
Wheel Running ◽  
Mdx Mice ◽  
Human Igg ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

2021 ◽  
Author(s):  
S.E. Hamm ◽  
D.D. Fathalikhani ◽  
K.E. Bukovec ◽  
A.K. Addington ◽  
H. Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Muscle Function ◽  
Wheel Running ◽  
Mdx Mice ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Voluntary wheel running complements microdystrophin gene therapy to improve muscle function in mdx mice

2021 ◽  
Vol 23 ◽  
pp. 460
Author(s):  
Shelby E. Hamm ◽  
Daniel D. Fathalikhani ◽  
Katherine E. Bukovec ◽  
Adele K. Addington ◽  
Haiyan Zhang ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Muscle Function ◽  
Wheel Running ◽  
Mdx Mice ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Membrane Estrogen Receptors Regulate Voluntary Wheel Running and Contractile Function in Skeletal Muscle in Mice

2011 ◽  
Vol 43 (Suppl 1) ◽  
pp. 781
Author(s):  
Jacqueline M. Crissey ◽  
J. Andries Ferreira ◽  
Dennis B. Lubahn ◽  
Marybeth Brown
Keyword(s):  
Skeletal Muscle ◽  
Estrogen Receptors ◽  
Wheel Running ◽  
Contractile Function ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

scholarly journals Voluntary Wheel Running Selectively Augments Insulin-Stimulated Vasodilation in Arterioles from White Skeletal Muscle of Insulin-Resistant Rats

2012 ◽  
Vol 19 (8) ◽  
pp. 729-738 ◽  
Author(s):  
Catherine R. Mikus ◽  
Bruno T. Roseguini ◽  
Grace M. Uptergrove ◽  
E. Matthew Morris ◽  
Randy Scott Rector ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Insulin Resistant ◽  
Voluntary Wheel

scholarly journals The Effect of Voluntary Wheel Running on Muscle Mass, Mitochondrial Function and Oxidative Damage in Sod1???/???mice

2006 ◽  
Vol 38 (Suppl 1) ◽  
pp. S12
Author(s):  
Michael S. Lustgarten ◽  
Young C. Jang ◽  
Wook Song ◽  
Yuhong Liu ◽  
Anson Pierce ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Muscle Mass ◽  
Mitochondrial Function ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

P.1.05 Involvement of DARPP-32, FosB, and dynorphin in voluntary wheel running

2008 ◽  
Vol 18 ◽  
pp. s5-s6 ◽  
Author(s):  
A. Borgkvist ◽  
E.J. Nestler ◽  
P. Greengard ◽  
G. Fisone ◽  
S. Brené
Keyword(s):  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats

2009 ◽  
Vol 87 (3) ◽  
pp. 211-220 ◽  
Author(s):  
Nicola Hopwood ◽  
Tlangelani Maswanganyi ◽  
Lois M. Harden
Keyword(s):  
Wheel Running ◽  
Poly I:C ◽  
Sprague Dawley ◽  
Voluntary Wheel Running ◽  
Polycytidylic Acid ◽  
Cage Activity ◽  
Sprague Dawley Rats ◽  
Sickness Behaviors ◽  
Saline Administration ◽  
Voluntary Wheel

Although it has been established that some acute phase responses present differently depending on whether a virus or bacteria activates the innate immune system, it has not yet been established whether fever and sickness behaviors, such as anorexia and lethargy, present differently. We therefore investigated the effects of administering lipopolysaccharide (LPS) and polyinosinic : polycytidylic acid (poly I:C) on body temperature, food intake, body mass, and activity (cage activity and wheel running). Male Sprague–Dawley rats were randomly assigned to receive an intraperitoneal injection of one of LPS (75 µg/kg or 250 µg/kg), poly I:C (3000 µg/kg or 4000 µg/kg), or saline. Administration of LPS or poly I:C induced fever, anorexia, and lethargy. Although voluntary wheel running and cage activity were both significantly reduced after administration of LPS or poly I:C, they were not affected equally. Indeed voluntary wheel running was decreased on average by approximately 30% more than cage activity regardless of the dose or type of mimetic administered. Our results indicate that poly I:C is less effective at inducing anorexia, lethargy, and fever in rats than is LPS, and that avoidance of exercise in animals and humans during infection is likely to be a more prominent feature of illness than is avoidance of routine daily activity.

Abstract 12231: PECAM1 is Essential for Flow-mediated Gab1 Tyrosine Phosphorylation and Signaling in vitro and in vivo

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Suowen Xu ◽  
Marina Koroleva ◽  
Keigi Fujiwara ◽  
Zheng Gen Jin
Keyword(s):  
Tyrosine Phosphorylation ◽  
Wheel Running ◽  
Tyrosine Phosphatase ◽  
Common Mechanism ◽  
Membrane Localization ◽  
No Production ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Introduction: Impaired activation of endothelial nitric oxide (NO) synthase (eNOS) and ensued NO production is a common mechanism of various cardiovascular pathologies, including hypertension and atherosclerosis. Specific signaling cascades, generated by vascular endothelial cells (ECs) in response to laminar flow, modulate EC structure and functions, NO production in particular. We have previously shown that flow-stimulated Gab1 (Grb2-associated binder-1) tyrosine phosphorylation mediates eNOS activation. However, the upstream mechanism that regulates Gab1 tyrosine phosphorylation remains unclear. Hypothesis: We hypothesized that platelet endothelial cell adhesion molecule-1 (PECAM1), a key molecule in an endothelial mechanosensing complex, specifically mediates Gab1 tyrosine phosphorylation and its downstream Akt and eNOS activation in ECs upon flow rather than hepatocyte growth factor (HGF) stimulation. Methods: Western blot, en face staining and voluntary wheel running. Results: Small interfering RNA (siRNA) targeting PECAM1 abolished flow- but not HGF-induced Gab1 tyrosine phosphorylation and Akt, eNOS activation as well as Gab1 membrane translocation. Protein-tyrosine phosphatase SHP2, which has been shown to interact with Gab1, was involved in a flow signaling pathway as well as HGF-induced signaling, as SHP2 siRNA diminished the flow- and HGF-induced Gab1 tyrosine phosphorylation, membrane localization and downstream signaling. Pharmacological inhibition of PI3K by LY294002 decreased flow, but not HGF-mediated Gab1 phosphorylation and membrane localization as well as eNOS activation. Finally, we observed that flow-mediated Gab1 and eNOS phosphorylation in vivo induced by voluntary wheel running was reduced in PECAM1 knockout mice. Conclusions: These results demonstrate a specific role of PECAM1 in flow-mediated Gab1 tyrosine phosphorylation and eNOS signaling in ECs

scholarly journals The effects of 8 weeks voluntary wheel running on the contractile performance of isolated locomotory (soleus) and respiratory (diaphragm) skeletal muscle during early ageing

2017 ◽  
Vol 220 (20) ◽  
pp. 3733-3741 ◽  
Author(s):  
Jason Tallis ◽  
Matthew F. Higgins ◽  
Frank Seebacher ◽  
Val M. Cox ◽  
Michael J. Duncan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Wheel Running ◽  
Voluntary Wheel Running ◽  
Contractile Performance ◽  
Voluntary Wheel
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