Evidence for the role of sphingomyelin and lipid rafts in Ca 2+ -gating of the Transient Receptor Potential channels in trigeminal sensory neurons and peripheral nerve terminals

Neuropeptides ◽  
2017 ◽  
Vol 65 ◽  
pp. 132
Author(s):  
Éva Szoke ◽  
Éva Sághy ◽  
Maja Payrits ◽  
Zsuzsanna Helyes ◽  
János Erostyák ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Lipid Rafts ◽  
Sensory Neurons ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Nerve Terminals ◽  
Potential Channels ◽  
Transient Receptor

What Evolutionary Evidence Implies About the Identity of the Mechanoelectrical Couplers in Vascular Smooth Muscle Cells

Physiology ◽  
2021 ◽  
Vol 36 (5) ◽  
pp. 292-306
Author(s):  
Heather A. Drummond
Keyword(s):  
Transient Receptor Potential ◽  
Molecular Model ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Potential Channels ◽  
Transient Receptor ◽  
Paradigm Shifting ◽  
G Protein Coupled ◽  
Evolutionary Role

Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the 1) evolutionary role of these molecules in mechanosensing, 2) limitations to identifying mechanosensitive molecules, and 3) paradigm shifting molecular model for a VSMC mechanosensor.

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