paradigm shifting
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2022 ◽  
Author(s):  
Jennifer L Tackett ◽  
Kathleen Wade Reardon ◽  
Melissa Kaufman ◽  
Ryne A. Sherman

Personality disorder (PD) researchers proposed a highly innovative “paradigm-shifting” revamp for the Diagnostic and Statistical Manual of Mental Disorders 5th edition (DSM-5; APA, 2013). Yet, ten years later, Widiger and Hines (this issue) summarize a developmental process plagued by disagreement and stagnation, with little evidence of the field having reaped the desired benefits of this diagnostic revolution. In this commentary, we draw on principles from entrepreneurial creation, operation, and success—positioning the personality disorder scientists in the role of “disruptive innovator”—and summarize key principles from the entrepreneurial process that may be relevant in understanding the challenges and failures of the personality disorder revolution to date.


Author(s):  
Evan J. Giangrande ◽  
Ramona S. Weber ◽  
Eric Turkheimer

In the second half of the twentieth century, twin and family studies established beyond a reasonable doubt that all forms of psychopathology are substantially heritable and highly polygenic. These conclusions were simultaneously an important theoretical advance and a difficult methodological obstacle, as it became clear that heritability is universal and undifferentiated across forms of psychopathology, and the radical polygenicity of genetic effects limits the biological insight provided by genetically informed studies at the phenotypic level. The paradigm-shifting revolution brought on by the Human Genome Project has recapitulated the great methodological promise and the profound theoretical difficulties of the twin study era. We review these issues using the rubric of genetic architecture, which we define as a search for specific genetic insight that adds to the general conclusion that psychopathology is heritable and polygenic. Although significant problems remain, we see many promising avenues for progress. Expected final online publication date for the Annual Review of Clinical Psychology, Volume 18 is May 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.


2021 ◽  
pp. 209-232
Author(s):  
Ashish Dhayani ◽  
Preethem Srinath ◽  
Sujanthi Easwara Prasad ◽  
Afsana Naaz ◽  
Mukesh Dhanka ◽  
...  

Electricity ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 459-470
Author(s):  
Dimitra Zarbouti ◽  
Elisavet Koutsi ◽  
Georgia Athanasiadou ◽  
George Tsoulos

Electric cars sales have been rising almost steadily over the past decade. Uncontrolled charging has recently emerged as the main detrimental factor to this otherwise environmentally friendly and paradigm shifting technology due to the incurred impact on the energy grid. In addition, people are usually hesitant in allowing their vehicles to be controlled by external units; therefore, controlled charging strategies that offer users the option to have some control over their vehicles seems to be a sensible choice moving towards a gasoline-free vehicles market. This work investigated two price-sensitive charging strategies that allowed users to control the charging of their vehicle in order to receive cost benefits. These strategies were of a parametric nature; thus, the analysis focused on providing useful rules of thumb to guide users in choosing the most suitable strategy and the relevant parameters according to their driving profiles. The results show that when driving less than 40 km/h on average and employing a price-sensitive charging strategy with the proposed optimized parameters, electric car users may obtain 30–40% of the running cost reduction.


2021 ◽  
Vol 34 (3) ◽  
pp. 372-384
Author(s):  
Alexander Unzicker

Since Isaac Newton, many physicists have conveyed the idea of the true laws of nature being governed by “simplicity,” a notion that has rarely been properly defined. When analyzing the history of fundamental physics until 1930, the number of constants of nature appears to be a useful measure for the complexity of theories, as opposed to the notion of simplicity. It can be observed that paradigm-shifting progress is often related to explanations of physical constants, thereby reducing their total number. Thus, it is argued that scientific revolutions are usually characterized by a pattern consisting of (1) a conceptual idea, (2) a mathematical formalism, and (3) a reduction of the number of independent constants of nature. This leads to a better understanding of the long-term impact of physical theories and may help to evaluate the current state of fundamental physics.


Biomolecules ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1331
Author(s):  
André Luís Condeles ◽  
José Carlos Toledo Junior

While investigating peroxynitrite-dependent oxidation in murine RAW 264.7 macrophage cells, we observed that removal of the Labile Iron Pool (LIP) by chelation increases the intracellular oxidation of the fluorescent indicator H2DCF, so we concluded that the LIP reacts with peroxynitrite and decreases the yield of peroxynitrite-derived oxidants. This was a paradigm-shifting finding in LIP biochemistry and raised many questions. In this follow-up study, we address fundamental properties of the interaction between the LIP and peroxynitrite by using the same cellular model and fluorescence methodology. We have identified that the reaction between the LIP and peroxynitrite has catalytic characteristics, and we have estimated that the rate constant of the reaction is in the range of 106 to 107 M−1s−1. Together, these observations suggest that the LIP represents a constitutive peroxynitrite reductase system in RAW 264.7 cells.


Physiology ◽  
2021 ◽  
Vol 36 (5) ◽  
pp. 292-306
Author(s):  
Heather A. Drummond

Loss of pressure-induced vasoconstriction increases susceptibility to renal and cerebral vascular injury. Favored paradigms underlying initiation of the response include transient receptor potential channels coupled to G protein-coupled receptors or integrins as transducers. Degenerin channels may also mediate the response. This review addresses the 1) evolutionary role of these molecules in mechanosensing, 2) limitations to identifying mechanosensitive molecules, and 3) paradigm shifting molecular model for a VSMC mechanosensor.


Author(s):  
Alexandros Nikitas ◽  
Nikolas Thomopoulos ◽  
Dimitris Milakis

Automation carries paradigm-shifting potential for urban transport and has critical sustainability dimensions for the future of our cities. This article examines the diverse environmental and energy-related dimensions of automated mobility at the city level by reviewing an emerging and increasingly diversified volume of literature for road, rail, water, and air passenger transport. The multimodal nature of this investigation provides the opportunity for a novel contribution that adds value to the literature in four distinctive ways. It reviews from a sustainability angle the state of the art underpinning the transition to a paradigm of automated mobility, identifies current knowledge gaps highlighting the scarcity of non-technical research outside the autonomous car's realm, articulates future directions for research and policy development, and proposes a conceptual model that contextualizes the automation-connectivity-electrification-sharing-multimodality nexus as the only way forward for vehicle automation to reach its pro-environmental and resource-saving potential. Expected final online publication date for the Annual Review of Environment and Resources, Volume 46 is October 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.


2021 ◽  
Author(s):  
Courtney Cole ◽  
Jacqueline Marhefka ◽  
Kathryn Jablokow ◽  
Susan Mohammed ◽  
Sarah Ritter ◽  
...  

Abstract Nearly 60 years ago, Thomas Kuhn revolutionized how we think of scientific discovery and innovation when he identified that scientific change can occur in incremental developments that improve upon existing solutions, or it can occur as drastic change in the form of a paradigm shift. In engineering design, both types of scientific change are critical when exploring the solution space. However, most methods of examining design outputs look at whether an idea is creative or not and not the type of creativity that is deployed or if we can predict what types of individuals or teams is more likely to develop a paradigm-shifting idea. Without knowing how to identify who will generate ideas that fit a certain paradigm, we do not know how to build teams that can develop ideas that better explore the solution space. This study provides the first attempt at answering this question through an empirical study with 60 engineering design student teams over the course of a 4- and 8-week design project. Specifically, we sought to identify the role of cognitive style using KAI score, derived from Kirton’s Adaption-Innovation (A-I) theory, on the paradigm-relatedness of ideas generated by individuals and teams. We also sought to investigate the role of crowdsourcing for measuring the paradigm-relatedness of design solutions. The results showed that KAI was positively related to a greater likelihood of an individual’s idea being categorized as paradigm-breaking. In addition, the team KAI diversity was also linked to a greater likelihood of teams’ ideas being categorized as paradigm-challenging. Finally, the results support the use of crowdsourcing for measuring the paradigm-relatedness of design solutions.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alexey M. Romshin ◽  
Vadim Zeeb ◽  
Artem K. Martyanov ◽  
Oleg S. Kudryavtsev ◽  
Dmitrii G. Pasternak ◽  
...  

AbstractNanodiamonds hosting temperature-sensing centers constitute a closed thermodynamic system. Such a system prevents direct contact of the temperature sensors with the environment making it an ideal environmental insensitive nanosized thermometer. A new design of a nanodiamond thermometer, based on a 500-nm luminescent nanodiamond embedded into the inner channel of a glass submicron pipette is reported. All-optical detection of temperature, based on spectral changes of the emission of “silicon-vacancy” centers with temperature, is used. We demonstrate the applicability of the thermometric tool to the study of temperature distribution near a local heater, placed in an aqueous medium. The calculated and experimental values of temperatures are shown to coincide within measurement error at gradients up to 20 °C/μm. Until now, temperature measurements on the submicron scale at such high gradients have not been performed. The new thermometric tool opens up unique opportunities to answer the urgent paradigm-shifting questions of cell physiology thermodynamics.


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